PMID- 33761589
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20210720
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 137
DP  - 2021 May
TI  - The multi-faceted role of retinoid X receptor in cardiovascular diseases.
PG  - 111264
LID - S0753-3322(21)00049-4 [pii]
LID - 10.1016/j.biopha.2021.111264 [doi]
AB  - Retinoid X receptors (RXRs) are members of ligand-dependent transcription factors 
      whose effects on a diversity of cellular processes, including cellular 
      proliferation, the immune response, and lipid and glucose metabolism. Knock out 
      of RXRalpha causes a hypoplasia of the myocardium which is lethal during fetal life. 
      In addition, the heart maintains a well-orchestrated balances in utilizing fatty 
      acids (FAs) and other substrates to meet the high energy requirements. As the 
      master transcriptional regulators of lipid metabolism, RXRs become particularly 
      important for the energy needs of the heart. Accumulating evidence suggested that 
      RXRs may exert direct beneficial effects in the heart both through 
      heterodimerization with other nuclear receptors (NRs) and homodimerization, thus 
      standing as suitable targets for treating in cardiovascular diseases. Although 
      compounds that target RXRs are promising drugs, their use is limited by toxicity. 
      A better understanding of the structural biology of RXRs in cardiovascular 
      disease should enable the rational design of more selective nuclear receptor 
      modulators to overcome these problems. Here, this review summarizes a brief 
      overview of RXRs structure and versatility of RXR action in the control of 
      cardiovascular diseases. And we also discussed the therapeutic potential of RXR 
      ligand.
CI  - Copyright (c) 2021. Published by Elsevier Masson SAS.
FAU - Shao, Mingyan
AU  - Shao M
AD  - School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, 
      China.
FAU - Lu, Linghui
AU  - Lu L
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical 
      Sciences, Peking University, Beijing, 100191, China.
FAU - Ma, Lin
AU  - Ma L
AD  - School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, 
      China.
FAU - Tian, Xue
AU  - Tian X
AD  - School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, 
      China.
FAU - Li, Changxiang
AU  - Li C
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China.
FAU - Li, Chun
AU  - Li C
AD  - Modern Research Center of Traditional Chinese Medicine, School of Traditional 
      Chinese Material Medica, Beijing University of Chinese Medicine, Beijing, 100029, 
      China.
FAU - Guo, Dongqing
AU  - Guo D
AD  - School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, 
      China.
FAU - Wang, Qiyan
AU  - Wang Q
AD  - School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, 
      China.
FAU - Wang, Wei
AU  - Wang W
AD  - School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, 
      China. Electronic address: wangwei26960@126.com.
FAU - Wang, Yong
AU  - Wang Y
AD  - School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, 
      China; College of Traditional Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, 100029, China. Electronic address: wangyong@bucm.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210223
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Ligands)
RN  - 0 (Retinoid X Receptors)
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/*genetics
MH  - Gene Expression Regulation
MH  - Humans
MH  - Ligands
MH  - Retinoid X Receptors/*genetics
OTO - NOTNLM
OT  - Cardiovascular diseases
OT  - RXRalpha ligand
OT  - Retinoid X receptors
EDAT- 2021/03/26 06:00
MHDA- 2021/07/21 06:00
CRDT- 2021/03/25 01:01
PHST- 2020/11/30 00:00 [received]
PHST- 2021/01/04 00:00 [revised]
PHST- 2021/01/07 00:00 [accepted]
PHST- 2021/03/25 01:01 [entrez]
PHST- 2021/03/26 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
AID - S0753-3322(21)00049-4 [pii]
AID - 10.1016/j.biopha.2021.111264 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2021 May;137:111264. doi: 10.1016/j.biopha.2021.111264. Epub 
      2021 Feb 23.