PMID- 33761620
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20210720
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 137
DP  - 2021 May
TI  - Modulation of untranslated region alternative polyadenylation in glioma 
      tumorigenesis.
PG  - 111416
LID - S0753-3322(21)00201-8 [pii]
LID - 10.1016/j.biopha.2021.111416 [doi]
AB  - RNA modification is an important form of regulation in cancer biology, that is 
      capable of affecting cell proliferation, migration, other genetic characteristics 
      of tumors, and protein expression. Recent research has shown that dysregulation 
      of RNA modification plays an important role in glioma pathogenesis. A key form of 
      RNA post-transcriptional modification, alternative polyadenylation (APA), may 
      represent a mechanism by which genes escape miRNA-mediated inhibition of cancer. 
      Global shortening of 3' untranslated region (3'-UTR)-mediated APA events have 
      become a potential novel marker of cancer progression. Current treatments in 
      which a single gene or pathway is targeted do not have significant therapeutic 
      benefits for glioma patients, while strategies that are less targeted, in which 
      inhibitors of major regulatory hubs such as APA regulators are utilized, may have 
      superior therapeutic effects. However, the precise mechanisms by which 
      untranslated region-alternative polyadenylation (UTR-APA) regulates glioma are 
      poorly understood. In the present review, we will discuss the important roles of 
      UTR-APA in glioma. In addition to the role of APA in the progression of glioma, 
      we will also explore potential treatment options that target these processes to 
      improve the prognosis of glioma patients.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Lan, Yu-Long
AU  - Lan YL
AD  - Department of Neurosurgery, Second Affiliated Hospital, School of medicine, 
      Zhejiang University, Hangzhou, 310000, China. Electronic address: 
      lanyulong@zju.edu.cn.
FAU - Zhang, Jianmin
AU  - Zhang J
AD  - Department of Neurosurgery, Second Affiliated Hospital, School of medicine, 
      Zhejiang University, Hangzhou, 310000, China. Electronic address: 
      zjm135@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210224
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Polymers)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - 3' Untranslated Regions/*genetics
MH  - Adenine/*metabolism
MH  - Animals
MH  - Brain Neoplasms/*genetics/metabolism
MH  - Carcinogenesis/genetics
MH  - Glioma/*genetics/metabolism
MH  - Humans
MH  - Polyadenylation/*genetics
MH  - Polymers/metabolism
MH  - Prognosis
OTO - NOTNLM
OT  - Alternative polyadenylation
OT  - Glioma
OT  - Modulation
EDAT- 2021/03/26 06:00
MHDA- 2021/07/21 06:00
CRDT- 2021/03/25 01:01
PHST- 2020/12/23 00:00 [received]
PHST- 2021/02/12 00:00 [revised]
PHST- 2021/02/16 00:00 [accepted]
PHST- 2021/03/25 01:01 [entrez]
PHST- 2021/03/26 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
AID - S0753-3322(21)00201-8 [pii]
AID - 10.1016/j.biopha.2021.111416 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2021 May;137:111416. doi: 10.1016/j.biopha.2021.111416. Epub 
      2021 Feb 24.