PMID- 33761659
OWN - NLM
STAT- MEDLINE
DCOM- 20210401
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 12
DP  - 2021 Mar 26
TI  - Clinicopathological significance of SOX4 and epithelial-mesenchymal transition 
      markers in patients with laryngeal squamous cell carcinoma.
PG  - e25028
LID - 10.1097/MD.0000000000025028 [doi]
LID - e25028
AB  - BACKGROUND AND AIM: Sex-determining region-Y-related high-mobility-group box 4 
      (SOX4) is associated with the metastasis and prognosis of many cancer types. 
      However, studies on the role of SOX4 in laryngeal squamous cell carcinoma (LSCC) 
      are few, and hence the mechanism is unclear. Epithelial-mesenchymal transition 
      (EMT) allows neoplastic cells to gain the plasticity and motility required for 
      tumor progression and metastasis. This study aimed to analyze the relationship 
      between SOX4 and EMT, and their relationship with clinicopathological factors and 
      related prognosis. METHODS: Immunohistochemical staining was used to detect the 
      positive expression of SOX4 protein, EMT-related transcription factor protein, 
      and related marker protein in 127 LSCC tissue samples. At the same time, data on 
      various parameters of clinical pathology and postoperative survival were 
      collected. RESULTS: The positive expression rate of SOX4 and Slug in LSCC was 
      related to pathological differentiation, lymphatic invasion, and pathological 
      tumor node metastasis (TNM) of a tumor. The expression rates of ZEB1, Twist, 
      E-cadherin, N-cadherin, and beta-catenin in LSCC correlated with lymphatic invasion 
      and pathological tumor node metastasis. The expression of SOX4, combined 
      expression of SOX4 and ZEB1, and lymphatic invasion were independent prognostic 
      factors for the total survival time of patients with LSCC. CONCLUSIONS: In 
      summary, SOX4 was vital in the LSCC EMT process, which might be mediated by 
      transcription factor ZEB1. SOX4 and ZEB1 might serve as potential biomarkers of 
      metastasis and prognosis, as well as promising therapeutic targets of LSCC.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Zhang, Mingjie
AU  - Zhang M
AD  - Department Of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, 
      Guangdong.
AD  - Department Of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui, China.
FAU - Li, Hui
AU  - Li H
AD  - Department Of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, 
      Guangdong.
AD  - Department Of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui, China.
FAU - Han, Yuefeng
AU  - Han Y
AD  - Department Of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, 
      Guangdong.
AD  - Department Of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui, China.
FAU - Wang, Mengjun
AU  - Wang M
AD  - Department Of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, 
      Guangdong.
AD  - Department Of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui, China.
FAU - Zhang, Junjie
AU  - Zhang J
AD  - Department Of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, 
      Guangdong.
AD  - Department Of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui, China.
FAU - Ma, Shiyin
AU  - Ma S
AUID- ORCID: 0000-0001-6867-7200
AD  - Department Of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, 
      Guangdong.
AD  - Department Of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital 
      of Bengbu Medical College, Bengbu, Anhui, China.
LA  - eng
GR  - KJ2019A0376/University Natural Science Research Project of Anhui Province/
GR  - KJ2019A0400/University Natural Science Research Project of Anhui Province/
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CDH1 protein, human)
RN  - 0 (CDH2 protein, human)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (SNAI1 protein, human)
RN  - 0 (SOX4 protein, human)
RN  - 0 (SOXC Transcription Factors)
RN  - 0 (Snail Family Transcription Factors)
RN  - 0 (TWIST1 protein, human)
RN  - 0 (Twist-Related Protein 1)
RN  - 0 (ZEB1 protein, human)
RN  - 0 (Zinc Finger E-box-Binding Homeobox 1)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Antigens, CD/genetics
MH  - Biomarkers, Tumor/*genetics
MH  - Cadherins/genetics
MH  - Carcinoma, Squamous Cell/*genetics/*pathology
MH  - Epithelial-Mesenchymal Transition/*genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Nuclear Proteins/genetics
MH  - Prognosis
MH  - SOXC Transcription Factors/*genetics
MH  - Snail Family Transcription Factors/genetics
MH  - Twist-Related Protein 1/genetics
MH  - Zinc Finger E-box-Binding Homeobox 1/genetics
MH  - beta Catenin/genetics
PMC - PMC9282127
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2021/03/26 06:00
MHDA- 2021/04/02 06:00
PMCR- 2021/03/26
CRDT- 2021/03/25 01:02
PHST- 2020/10/05 00:00 [received]
PHST- 2021/02/07 00:00 [accepted]
PHST- 2021/03/25 01:02 [entrez]
PHST- 2021/03/26 06:00 [pubmed]
PHST- 2021/04/02 06:00 [medline]
PHST- 2021/03/26 00:00 [pmc-release]
AID - 00005792-202103260-00035 [pii]
AID - MD-D-20-09259 [pii]
AID - 10.1097/MD.0000000000025028 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Mar 26;100(12):e25028. doi: 
      10.1097/MD.0000000000025028.