PMID- 33761667 OWN - NLM STAT- MEDLINE DCOM- 20210330 LR - 20230103 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 100 IP - 12 DP - 2021 Mar 26 TI - His bundle pacing therapy for patients with chronic heart failure: A protocol for meta-analysis based on prospective studies. PG - e25079 LID - 10.1097/MD.0000000000025079 [doi] LID - e25079 AB - INTRODUCTION: A considerable amount of studies have been published with the results of clinical benefit from his bundle pacing (HBP) for chronic heart failure (CHF) patients and these researches led a uncertain conclusion for clinics. Thus, we will conduct a meta-analysis to evaluate the effect of his bundle pacing therapy for chronic heart failure. METHODS: Pubmed, EMBASE, the Cochrane Library, Web of Science and Chinese online databases including Chinese National Knowledge Infrastructure, China Biology Medicine disc, Chinese Scientifific Journals Database (VIP), and Wanfang Database will be searched from these databases construction to the end of November, 2020. The STATA 13.0 will be used for data synthesis and meta-analysis. RESULTS: The outcome measures included QRS duration, left ventricular ejection fraction, pacing threshold, New York Heart Association (NYHA), left ventricular end-diastolic diameter, left ventricular end-systolic diameter, mitral regurgitation, tricuspid regurgitation, and BNP will be analyzed and synthesized. CONCLUSION: This meta-analysis will evaluate the effect of his bundle pacing therapy for chronic heart failure. REGISTRATION NUMBER: INPLASY202110109. CI - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Zhang, Yongzheng AU - Zhang Y AUID- ORCID: 0000-0002-6071-3956 AD - Department of CCU, Gansu Provincial Third Hospital, Lanzhou, China. FAU - Ding, Mingwang AU - Ding M FAU - Pu, Zhihong AU - Pu Z FAU - Peng, Wenjia AU - Peng W LA - eng GR - GSWSKY2017-21/Science Research Program of Gansu Province/ PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Adult MH - Aged MH - Bundle of His/*physiopathology MH - Cardiac Pacing, Artificial/*methods MH - Chronic Disease MH - Female MH - Heart Failure/physiopathology/*therapy MH - Humans MH - Male MH - Meta-Analysis as Topic MH - Middle Aged MH - Prospective Studies MH - Research Design MH - Systematic Reviews as Topic MH - Treatment Outcome MH - Young Adult PMC - PMC9281952 COIS- The authors have no conflicts of interest to disclose. EDAT- 2021/03/26 06:00 MHDA- 2021/03/31 06:00 PMCR- 2021/03/26 CRDT- 2021/03/25 01:02 PHST- 2021/02/03 00:00 [received] PHST- 2021/02/08 00:00 [accepted] PHST- 2021/03/25 01:02 [entrez] PHST- 2021/03/26 06:00 [pubmed] PHST- 2021/03/31 06:00 [medline] PHST- 2021/03/26 00:00 [pmc-release] AID - 00005792-202103260-00043 [pii] AID - MD-D-21-00782 [pii] AID - 10.1097/MD.0000000000025079 [doi] PST - ppublish SO - Medicine (Baltimore). 2021 Mar 26;100(12):e25079. doi: 10.1097/MD.0000000000025079.