PMID- 33761736
OWN - NLM
STAT- MEDLINE
DCOM- 20210405
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 12
DP  - 2021 Mar 26
TI  - Lack of association between single nucleotide polymorphisms in TCF7L2 and T2DM in 
      the Chinese Yao population: A case-control study.
PG  - e25326
LID - 10.1097/MD.0000000000025326 [doi]
LID - e25326
AB  - Single-nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 
      (TCF7L2) gene have been identified to be associated with the susceptibility to 
      type 2 diabetes mellitus (T2DM) in various populations worldwide, but the results 
      in Chinese are conflicting, and no data are available about the Liannan Yao 
      population. Therefore, this study aimed to investigate the association of the 
      TCF7L2 gene polymorphisms (rs12255372, rs7903146, rs7901695, rs11196205, and 
      rs7895340) with T2DM in the Yao population living in the rural areas in the 
      Liannan Yao Autonomous County.This was a case-control study of 28 subjects with 
      T2DM or prediabetes and 52 non-T2DM controls, all from the Chinese Yao population 
      and recruited between January 2019 and June 2020. Patients with T2DM and 
      prediabetes were grouped as the case group. The five SNPs (rs12255372, rs7903146, 
      rs7901695, rs11196205, and rs7895340) were examined by polymerase chain reaction 
      and direct genomic DNA sequencing in case and control groups.The subjects in case 
      group were older than the controls (55+/-14 vs 48 +/- 15 years, P = .047), had higher 
      FBG levels (9.31 +/- 5.43 vs 4.09 +/- 0.81, P < .001), higher TC (5.79 +/- 1.29 vs 
      5.13 +/- 1.18 mmol/L, P = .025), and higher triglycerides (2.94 +/- 2.04 vs 
      1.86 +/- 1.39 mmol/L, P = .003). The genotypic distribution for each of the SNPs 
      was in agreement with the Hardy-Weinberg equilibrium. There were no statistically 
      significant differences in the distributions of genotypes or alleles at all five 
      SNPs of the TCF7L2 gene between the case and control groups (all P > .05).TCF7L2 
      SNPs were not associated with T2DM in the Liannan Yao population.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Sun, Shi-Yu
AU  - Sun SY
AD  - School of the Third Clinical Medicine, Guangzhou University of Chinese Medicine.
FAU - Huang, Run-Ze
AU  - Huang RZ
AD  - Department of Endocrinology, The First Affiliated Hospital of Guangdong 
      Pharmaceutical University, Guangzhou, China.
FAU - Huang, Huang
AU  - Huang H
AD  - Department of Endocrinology, The First Affiliated Hospital of Guangdong 
      Pharmaceutical University, Guangzhou, China.
FAU - Zhang, Ming-Qi
AU  - Zhang MQ
AD  - Department of Endocrinology, The First Affiliated Hospital of Guangdong 
      Pharmaceutical University, Guangzhou, China.
FAU - Sun, Hui-Lin
AU  - Sun HL
AUID- ORCID: 0000-0001-5490-7423
AD  - Department of Endocrinology, The First Affiliated Hospital of Guangdong 
      Pharmaceutical University, Guangzhou, China.
LA  - eng
GR  - 2017ZC0203/Natural Science Foundation of Guangdong Province/
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Cholesterol/blood
MH  - Correlation of Data
MH  - *Diabetes Mellitus, Type 2/blood/diagnosis/epidemiology/genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Transcription Factor 7-Like 2 Protein/*genetics
MH  - Triglycerides/blood
PMC - PMC9282024
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2021/03/26 06:00
MHDA- 2021/04/07 06:00
PMCR- 2021/03/26
CRDT- 2021/03/25 01:02
PHST- 2020/10/10 00:00 [received]
PHST- 2021/03/01 00:00 [accepted]
PHST- 2021/03/25 01:02 [entrez]
PHST- 2021/03/26 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PHST- 2021/03/26 00:00 [pmc-release]
AID - 00005792-202103260-00112 [pii]
AID - MD-D-20-09986 [pii]
AID - 10.1097/MD.0000000000025326 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Mar 26;100(12):e25326. doi: 
      10.1097/MD.0000000000025326.