PMID- 33763060
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 12
DP  - 2021
TI  - Spondyloarthritis and the Human Leukocyte Antigen (HLA)-B(*)27 Connection.
PG  - 601518
LID - 10.3389/fimmu.2021.601518 [doi]
LID - 601518
AB  - Heritability of Spondyloarthritis (SpA) is highlighted by several familial 
      studies and a high association with the presence of human leukocyte antigen 
      (HLA)-B(*)27. Though it has been over four decades since the association of 
      HLA-B(*)27 with SpA was first determined, the pathophysiological roles played by 
      specific HLA-B(*)27 allotypes are not fully understood. Popular hypotheses 
      include the presentation of arthritogenic peptides, triggering of endoplasmic 
      reticulum (ER) stress by misfolded HLA-B(*)27, and the interaction between free 
      heavy chains or heavy chain homodimers of HLA-B(*)27 and immune receptors to 
      drive IL-17 responses. Several non-HLA susceptibility loci have also been 
      identified for SpA, including endoplasmic reticulum aminopeptidases (ERAP) and 
      those related to the IL-23/IL-17 axes. In this review, we summarize clinical 
      aspects of SpA including known characteristics of gut inflammation, enthesitis 
      and new bone formation and the existing models for understanding the association 
      of HLA-B(*)27 with disease pathogenesis. We also examine newer insights into the 
      biology of HLA class I (HLA-I) proteins and their implications for expanding our 
      understanding of HLA-B(*)27 contributions to SpA pathogenesis.
CI  - Copyright (c) 2021 Kavadichanda, Geng, Bulusu, Negi and Raghavan.
FAU - Kavadichanda, Chengappa G
AU  - Kavadichanda CG
AD  - Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Puducherry, India.
FAU - Geng, Jie
AU  - Geng J
AD  - Department of Microbiology and Immunology, University of Michigan Medical School, 
      Ann Arbor, MI, United States.
FAU - Bulusu, Sree Nethra
AU  - Bulusu SN
AD  - Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Puducherry, India.
FAU - Negi, Vir Singh
AU  - Negi VS
AD  - Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Puducherry, India.
FAU - Raghavan, Malini
AU  - Raghavan M
AD  - Department of Microbiology and Immunology, University of Michigan Medical School, 
      Ann Arbor, MI, United States.
LA  - eng
GR  - R01 AI044115/AI/NIAID NIH HHS/United States
GR  - R21 AI126054/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20210308
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-23)
SB  - IM
MH  - Endoplasmic Reticulum Stress/*immunology
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Interleukin-17/*immunology
MH  - Interleukin-23/*immunology
MH  - Spondylitis, Ankylosing/*immunology/pathology
PMC - PMC7982681
OTO - NOTNLM
OT  - ER stress
OT  - ERAP1
OT  - HLA-B*27
OT  - IL-23/IL-17 axis
OT  - free heavy chain
OT  - spondyloarthritis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/03/26 06:00
MHDA- 2021/06/24 06:00
PMCR- 2021/01/01
CRDT- 2021/03/25 06:27
PHST- 2020/09/01 00:00 [received]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/03/25 06:27 [entrez]
PHST- 2021/03/26 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2021.601518 [doi]
PST - epublish
SO  - Front Immunol. 2021 Mar 8;12:601518. doi: 10.3389/fimmu.2021.601518. eCollection 
      2021.