PMID- 33765899
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 32
IP  - 9
DP  - 2021 Jun
TI  - Optimally controlled morphology and physico-mechanical properties of inclusion 
      complex loaded electrospun polyvinyl alcohol based nanofibrous mats for 
      therapeutic applications.
PG  - 1182-1202
LID - 10.1080/09205063.2021.1909414 [doi]
AB  - Hydrophilic polyvinyl alcohol (PVA) based electrospun nanofibrous mats (ENMs) are 
      recently being used for the designing and fabrication of active wound dressing 
      materials. Thus, in this study an inclusion complex (IC) of curcumin (CUR) and 
      beta-cyclodextrin (beta-CD) was optimally incorporated in electrospun PVA nanofibers, 
      to obtain uniform bead-free nanofibers with minimum average diameter and 
      variation using Taguchi's design of experiments (DOE). The optimum level 
      parameters were ascertained using Taguchi's methodology, to obtain IC loaded PVA 
      based bead-free ENMs, by varying IC ( approximately 20,  approximately 40, and  approximately 60 wt.%) loading, applied 
      voltage, solution concentration, and N, N-dimethylformamide (DMF) content in the 
      electrospinning solution mixture. Validation experiments revealed a good 
      agreement between the predicted and experimental values of fiber diameter, 
      diameter-variation, and bead-numbers. Analysis of variance (ANOVA) showed a major 
      influence of IC loading on the average fiber diameter and the number of bead 
      defects, for IC-loaded PVA based ENMs. However, the DMF content of the solvent 
      mixture significantly influenced the diameter variations of ENMs. The surface 
      morphologies of ENMs were analyzed using Scanning Electron Microscopy (SEM) 
      whereas the microstructural aspects were studied by Wide-Angle X-ray Diffraction 
      (WAXD) and Fourier transform infrared (FT-IR) spectroscopy. The thermal 
      properties were characterized by differential scanning calorimetry (DSC) and 
      thermogravimetric analysis (TGA) whereas the mechanical properties were measured 
      by using uniaxial tensile testing and dynamic mechanical analysis (DMA). The 
      variation in properties of IC loaded PVA based ENMs were correlated with neat PVA 
      based ENMs fabricated using a similar set of optimized electrospinning process 
      parameters. The study conceptually demonstrated the optimal designing of 
      structurally-engineered hydrophilic IC loaded PVA based ENMs by using the Taguchi 
      approach based on orthogonal DOE as potential drug release substrates.
FAU - Sharma, Deepika
AU  - Sharma D
AD  - Department of Materials Science and Engineering, Indian Institute of Technology 
      Delhi, New Delhi, India.
FAU - Satapathy, Bhabani K
AU  - Satapathy BK
AD  - Department of Materials Science and Engineering, Indian Institute of Technology 
      Delhi, New Delhi, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210414
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 9002-89-5 (Polyvinyl Alcohol)
SB  - IM
MH  - Bandages
MH  - Calorimetry, Differential Scanning
MH  - *Nanofibers
MH  - *Polyvinyl Alcohol
MH  - Spectroscopy, Fourier Transform Infrared
OTO - NOTNLM
OT  - Biodegradable
OT  - curcumin
OT  - cyclodextrin
OT  - electrospinning
OT  - nanofibrous membranes
EDAT- 2021/03/27 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/03/26 05:37
PHST- 2021/03/27 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/03/26 05:37 [entrez]
AID - 10.1080/09205063.2021.1909414 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2021 Jun;32(9):1182-1202. doi: 
      10.1080/09205063.2021.1909414. Epub 2021 Apr 14.