PMID- 33766837
OWN - NLM
STAT- MEDLINE
DCOM- 20210519
LR  - 20210519
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 11
IP  - 3
DP  - 2021 Mar 25
TI  - Epidemiology and risk factors for diabetes in the suburbs of Beijing: a 
      retrospective cohort study.
PG  - e041526
LID - 10.1136/bmjopen-2020-041526 [doi]
LID - e041526
AB  - OBJECTIVE: We aimed to detect the incidence and risk factors of type 2 diabetes 
      mellitus (T2DM) development in the suburbs of Beijing. DESIGN: Cohort study with 
      record linkage to incidence data. SETTING: We performed a 5-year follow-up study 
      in a randomly selected suburban population including 1114 subjects aged >/=18 years 
      living in the suburbs of Beijing. PARTICIPANTS: 118 subjects with T2DM at 
      baseline according to the 1999 WHO criteria were excluded, and 895 subjects 
      attended the follow-up assessment in 2012. The non-diabetic subjects at baseline 
      were classified into two groups: normal glucose tolerance (NGT) group (n=673) and 
      impaired glucose regulation (IGR) group(n=222).The incidence and risk factors of 
      diabetes development in each group were investigated. OUTCOME MEASURES: A 
      structured questionnaire about sociodemographic characteristics, height, weight, 
      waist circumference, hip circumference, blood pressure, oral glucose tolerance 
      test and serum lipid levels. RESULTS: Out of the 895 non-diabetic subjects, 67 
      developed diabetes with 29 in the NGT group and 38 in the IGR group, 
      respectively, after a 5-year follow-up, producing an overall 5-year cumulative 
      incidence of diabetes of 13%. The incidence of diabetes was 15.5 cases per 1000 
      person-years, 8.9 cases per 1000 person-years in the NGT group and 35.7 cases per 
      1000 person-years in the IGR group (p<0.01; RR 4.03; 95% CI 2.58 to 9.29). Binary 
      logistic regression analysis showed that the risk factors for diabetes 
      development included fasting plasma glucose (FPG) in the NGT group, and sex, the 
      waist-to-hip ratio, FPG and diastolic blood pressure (DBP) in the IGR group. 
      CONCLUSIONS: During a mean follow-up of 5.0 years, the incidence of T2DM in the 
      suburbs of Beijing was 15.5 per 1000 person-years. Early prevention of diabetes 
      should focus on IGR subjects. Elevated FPG predicted diabetes development for 
      both NGT and IGR subjects. Female sex, overweight/obesity and DBP are risk 
      factors for diabetes development in IGR subjects.
CI  - (c) Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Xie, Lingding
AU  - Xie L
AD  - Endocrinology Department, China-Japan Friendship Hospital, Beijing, China.
FAU - Zhao, Xu
AU  - Zhao X
AD  - Endocrinology Department, Civil Aviation General Hospital, Beijing, China.
FAU - Zhang, Bo
AU  - Zhang B
AUID- ORCID: 0000-0003-3060-7850
AD  - Endocrinology Department, China-Japan Friendship Hospital, Beijing, China 
      drbozhang@yahoo.com.
FAU - Zhu, Haiqing
AU  - Zhu H
AD  - Endocrinology Department, China Meitan General Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210325
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Beijing/epidemiology
MH  - Blood Glucose
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - *Glucose Intolerance/epidemiology
MH  - Humans
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC7996367
OTO - NOTNLM
OT  - epidemiology
OT  - general diabetes
OT  - public health
COIS- Competing interests: None declared.
EDAT- 2021/03/27 06:00
MHDA- 2021/05/20 06:00
PMCR- 2021/03/25
CRDT- 2021/03/26 06:13
PHST- 2021/03/26 06:13 [entrez]
PHST- 2021/03/27 06:00 [pubmed]
PHST- 2021/05/20 06:00 [medline]
PHST- 2021/03/25 00:00 [pmc-release]
AID - bmjopen-2020-041526 [pii]
AID - 10.1136/bmjopen-2020-041526 [doi]
PST - epublish
SO  - BMJ Open. 2021 Mar 25;11(3):e041526. doi: 10.1136/bmjopen-2020-041526.