PMID- 33767404
OWN - NLM
STAT- MEDLINE
DCOM- 20211013
LR  - 20220720
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 56
IP  - 8
DP  - 2021 Aug
TI  - Natural killer cell alloreactivity in HLA-haploidentical hematopoietic 
      transplantation: a study on behalf of the CTIWP of the EBMT.
PG  - 1900-1907
LID - 10.1038/s41409-021-01259-0 [doi]
AB  - Human leukocyte antigen (HLA) class-I mismatches that trigger 
      donor-versus-recipient natural killer (NK)-cell alloreactivity reduce the 
      incidence of leukemia relapse and improve survival of acute myeloid leukemia 
      patients after T-cell-depleted HLA-haplotype mismatched ("haploidentical") 
      hematopoietic transplantation. In murine graft-versus-host disease (GvHD) models, 
      alloreactive NK-cells also prevent GvHD. Here we report the results of a 
      non-interventional, prospective study performed on behalf of the Cellular Therapy 
      and Immunobiology Working Party of the European Society for Blood and Marrow 
      Transplantation. The study was aimed at re-assessing the role of NK-cell 
      alloreactivity in a cohort of haploidentical transplants performed in Europe 
      between 2012 and 2015 and composed of unmanipulated, as well as T-cell-depleted 
      transplants. One hundred thirty-eight patients with acute myeloid or lymphoid 
      leukemias were analyzed. Eighty-six patients received ex-vivo T-cell-depleted 
      transplants, 52 patients received unmanipulated transplants. Fifty patients were 
      transplanted from NK alloreactive donors, 88 from non-NK alloreactive donors. NK 
      cell alloreactivity did not impact on GvHD/relapse-free survival (GRFS) in 
      unmanipulated transplants (HR: 1.66 (0.9-3.1), p = 0.1). In contrast, it did 
      impact beneficially on GRFS in T-cell-depleted transplants (HR: 0.6, (0.3-1.2), 
      p = 0.14, interaction p < 0.001). This effect was the consequence of reduced 
      incidences of acute and chronic GvHD and non-relapse mortality.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Ruggeri, Loredana
AU  - Ruggeri L
AUID- ORCID: 0000-0002-3804-2551
AD  - University of Perugia, Perugia, Italy. loredana.ruggeri@ospedale.perugia.it.
FAU - Vago, Luca
AU  - Vago L
AUID- ORCID: 0000-0003-4247-3175
AD  - Ospedale San Raffaele and Universita Vita-Salute San Raffaele, Milano, Italy.
FAU - Eikema, Diderik-Jan
AU  - Eikema DJ
AD  - EBMT Statistical Unit, Leiden, The Netherlands.
FAU - de Wreede, Liesbeth C
AU  - de Wreede LC
AD  - Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, 
      The Netherlands.
FAU - Ciceri, Fabio
AU  - Ciceri F
AD  - Ospedale San Raffaele and Universita Vita-Salute San Raffaele, Milano, Italy.
FAU - Diaz, Miguel Angel
AU  - Diaz MA
AD  - Nino Jesus Children's Hospital, Madrid, Spain.
FAU - Locatelli, Franco
AU  - Locatelli F
AD  - IRRCS Ospedale Pediatrico Bambino Gesu, Rome, Italy.
FAU - Jindra, Pavel
AU  - Jindra P
AUID- ORCID: 0000-0002-8415-7069
AD  - Charles University Hospital, Pilsen, Czech Republic.
FAU - Milone, Giuseppe
AU  - Milone G
AUID- ORCID: 0000-0002-7840-4414
AD  - Ospedale Ferrarotto, Catania, Italy.
FAU - Diez-Martin, Jose Luis
AU  - Diez-Martin JL
AD  - Hospital Gregorio Maranon, Madrid, Spain.
FAU - Perez-Simon, Jose Antonio
AU  - Perez-Simon JA
AD  - Hospital Universitario Virgen del Rocio, Sevilla, Spain.
FAU - Merluzzi, Mara
AU  - Merluzzi M
AD  - University of Perugia, Perugia, Italy.
FAU - Koster, Linda
AU  - Koster L
AD  - EBMT Data Office Leiden, Leiden, The Netherlands.
FAU - van der Werf, Steffie
AU  - van der Werf S
AD  - EBMT Data Office Leiden, Leiden, The Netherlands.
FAU - van Biezen, Anja
AU  - van Biezen A
AD  - EBMT Data Office Leiden, Leiden, The Netherlands.
FAU - Toubert, Antoine
AU  - Toubert A
AUID- ORCID: 0000-0002-7308-7317
AD  - Hopital Saint-Louis, APHP, INSERM U1160, Universite Paris Diderot, Paris, France.
FAU - Nagler, Arnon
AU  - Nagler A
AUID- ORCID: 0000-0002-0763-1265
AD  - Chaim Sheba Medical Center, Tel-Hashomer, Israel.
FAU - Chabannon, Christian
AU  - Chabannon C
AUID- ORCID: 0000-0002-3755-4889
AD  - Institut Paoli-Calmettes, Centre de Lutte Contre le Cancer; Centre 
      d'Investigations Cliniques en Biotherapie, Universite d'Aix-Marseille, Inserm 
      CBT, Marseille, France.
FAU - Bonini, Chiara
AU  - Bonini C
AD  - Ospedale San Raffaele and Universita Vita-Salute San Raffaele, Milano, Italy.
FAU - Velardi, Andrea
AU  - Velardi A
AD  - University of Perugia, Perugia, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210325
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Animals
MH  - *Graft vs Host Disease/prevention & control
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Killer Cells, Natural
MH  - *Leukemia, Myeloid, Acute/therapy
MH  - Mice
MH  - Prospective Studies
MH  - Transplantation, Haploidentical
EDAT- 2021/03/27 06:00
MHDA- 2021/10/14 06:00
CRDT- 2021/03/26 06:49
PHST- 2020/10/31 00:00 [received]
PHST- 2021/02/23 00:00 [accepted]
PHST- 2021/02/04 00:00 [revised]
PHST- 2021/03/27 06:00 [pubmed]
PHST- 2021/10/14 06:00 [medline]
PHST- 2021/03/26 06:49 [entrez]
AID - 10.1038/s41409-021-01259-0 [pii]
AID - 10.1038/s41409-021-01259-0 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2021 Aug;56(8):1900-1907. doi: 
      10.1038/s41409-021-01259-0. Epub 2021 Mar 25.