PMID- 33768242
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20211014
IS  - 1471-9053 (Electronic)
IS  - 0032-0781 (Linking)
VI  - 62
IP  - 5
DP  - 2021 Oct 1
TI  - ESCRT Is a Great Sealer: Non-Endosomal Function of the ESCRT Machinery in 
      Membrane Repair and Autophagy.
PG  - 766-774
LID - 10.1093/pcp/pcab045 [doi]
AB  - Components of the endosomal sorting complex required for transport (ESCRTs) were 
      first identified in a genetic screen in budding yeast as factors interfering with 
      vacuolar protein sorting. In the last three decades, intensive studies have 
      revealed the subunit composition of ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III, their 
      structure, the assembling mechanisms and their molecular and physiological 
      functions. In plants, ESCRTs are essential for development, growth and stress 
      responses. ESCRTs are best known for their function in endosomal trafficking, 
      during which they are required for sorting ubiquitylated membrane proteins into 
      intraluminal vesicles (ILVs) of multivesicular endosomes (MVEs). The formation of 
      ILVs requires the function of ESCRT-III, which has been shown to mediate the 
      membrane scission. Although the function of plant ESCRTs has been predominantly 
      discussed in the context of endosomal trafficking, recent studies in other model 
      organisms revealed a versatile role of ESCRTs in diverse cellular events with 
      broad physiological implications. The non-endosomal functions of ESCRTs include 
      cytokinesis, viral budding, autophagy, nuclear envelope reformation and membrane 
      repair, although many of these have not yet been studied in plants. In this 
      review, recent findings on non-endosomal ESCRT functions in plant, yeast and 
      animals are highlighted and discussed.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of Japanese 
      Society of Plant Physiologists. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Isono, Erika
AU  - Isono E
AUID- ORCID: 0000-0002-3754-8964
AD  - Department of Biology, University of Konstanz, Universitatsstrasse 10, Konstanz 
      78464, Germany.
LA  - eng
GR  - SFB969/TPC08/The German Science Foundation (DFG)/
GR  - 1198564/Alexander von Humboldt Foundation/
GR  - Zukunftskolleg of the University of Konstanz/
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Plant Cell Physiol
JT  - Plant & cell physiology
JID - 9430925
RN  - 0 (Endosomal Sorting Complexes Required for Transport)
SB  - IM
MH  - Animals
MH  - Autophagy/*physiology
MH  - Cell Membrane/*metabolism/pathology
MH  - Endosomal Sorting Complexes Required for Transport/*physiology
MH  - Endosomes/metabolism
MH  - Peroxisomes/metabolism
MH  - Plant Cells/metabolism/pathology
MH  - Plants/metabolism
MH  - Yeasts/metabolism
OTO - NOTNLM
OT  - Autophagy
OT  - ESCRT
OT  - Membrane repair
OT  - Membrane scission
OT  - Nuclear envelope
EDAT- 2021/03/27 06:00
MHDA- 2021/10/15 06:00
CRDT- 2021/03/26 07:04
PHST- 2020/12/31 00:00 [received]
PHST- 2021/02/18 00:00 [revised]
PHST- 2021/03/23 00:00 [accepted]
PHST- 2021/03/27 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
PHST- 2021/03/26 07:04 [entrez]
AID - 6188632 [pii]
AID - 10.1093/pcp/pcab045 [doi]
PST - ppublish
SO  - Plant Cell Physiol. 2021 Oct 1;62(5):766-774. doi: 10.1093/pcp/pcab045.