PMID- 33768408
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20210630
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 41
IP  - 7
DP  - 2021 Jul
TI  - Evaluation of macular, retinal nerve fiber layer and choroidal thickness by 
      optical coherence tomography in children and adolescents with vitamin B(12) 
      deficiency.
PG  - 2399-2404
LID - 10.1007/s10792-021-01794-1 [doi]
AB  - PURPOSE: To investigate macular, Retinal Nerve Fiber Layer (RNFL) and choroidal 
      thickness in children and adolescents with vitamin B(12) deficiency and no 
      neurological examination finding. METHODS: The study group includes of 
      thirty-three children aged 8-17 years who were brought to the Pediatric 
      outpatient clinic with the symptoms of fatigue and forgetfulness and whose 
      Vitamin B(12) levels were detected < 200 pg/ml. The control group was the 30 
      children and adolescents applied to the same policlinic with various symptoms and 
      whose Vitamin B(12) levels were found normal. Children and adolescents with 
      chronic systemic/ocular disease history and myopia or hyperopia more than 4 
      diopters were not included in both groups. Spectral Domain-Optical Coherence 
      Tomography (SD-OCT) was used for measurements. RESULTS: Mean Macular thickness 
      value was 261.2 +/- 17.6 in the Vitamin B(12) deficiency group and 267.7 +/- 17.4 in 
      the control group. Mean value of Retinal Nerve Fiber Layer (RNFL) thickness was 
      103.5 +/- 7.5 in the Vitamin B(12) deficiency group and 104.3 +/- 8.9 in the control 
      group. The mean values of Choroidal thickness were 360.1 +/- 59.8 and 316.9 +/- 95.4 
      in Vitamin B(12) deficiency and control groups, respectively. There was a 
      statistically significant increase in choroidal thickness in Vitamin B(12) 
      deficiency group compared to controls. CONCLUSION: Statistically significant 
      increase in the Choroidal thicknesses of children and adolescents with Vitamin 
      B(12) deficiency is important in terms of shedding light on studies that will 
      contribute to a better understanding of the relationship between vitamin B(12) 
      and inflammation. CLINICAL TRIAL REGISTRATION: This study is an observational 
      study.
FAU - Ayyildiz, Taha
AU  - Ayyildiz T
AUID- ORCID: 0000-0001-7938-5238
AD  - Ophthalmology Department, Bursa City Hospital, Bursa, Turkey.
FAU - Dulkadiroglu, Ramazan
AU  - Dulkadiroglu R
AD  - Department of Pediatrics, Faculty of Medicine, Kirsehir Ahi Evran University, 
      Kirsehir, Turkey. drdulkadir40@hotmail.com.
FAU - Yilmaz, Mevlut
AU  - Yilmaz M
AD  - Ophthalmology Department, Ulucanlar Eye Hospital, Ankara, Turkey.
FAU - Polat, Osman Ahmet
AU  - Polat OA
AD  - Ophthalmology Department, Faculty of Medicine, Kayseri Erciyes University, 
      Kayseri, Turkey.
FAU - Gunes, Ali
AU  - Gunes A
AD  - Department of Pediatrics, Faculty of Medicine, Kirsehir Ahi Evran University, 
      Kirsehir, Turkey.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210325
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
RN  - 0 (Vitamins)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Choroid
MH  - Humans
MH  - Nerve Fibers
MH  - *Tomography, Optical Coherence
MH  - *Vitamin B 12
MH  - Vitamins
OTO - NOTNLM
OT  - Adolescent
OT  - Children
OT  - Choroid thickness
OT  - Macula
OT  - RNFL
OT  - Vitamin B12 deficiency
EDAT- 2021/03/27 06:00
MHDA- 2021/07/01 06:00
CRDT- 2021/03/26 07:10
PHST- 2020/11/07 00:00 [received]
PHST- 2021/03/06 00:00 [accepted]
PHST- 2021/03/27 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2021/03/26 07:10 [entrez]
AID - 10.1007/s10792-021-01794-1 [pii]
AID - 10.1007/s10792-021-01794-1 [doi]
PST - ppublish
SO  - Int Ophthalmol. 2021 Jul;41(7):2399-2404. doi: 10.1007/s10792-021-01794-1. Epub 
      2021 Mar 25.