PMID- 33769018
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20211125
IS  - 2724-6442 (Electronic)
IS  - 2724-6051 (Linking)
VI  - 73
IP  - 4
DP  - 2021 Aug
TI  - Proton pump inhibitors use and risk of chronic kidney disease and end-stage renal 
      disease.
PG  - 462-470
LID - 10.23736/S2724-6051.21.04116-3 [doi]
AB  - INTRODUCTION: A possible association between long-term proton pump inhibitors 
      (PPI) use and chronic kidney disease (CKD) has been recently described. Due to 
      the potential health risk of this association, in the absence of proper clinical 
      trials, we have decided to carry out a systematic review followed by 
      meta-analysis. EVIDENCE ACQUISITION: PubMed, Cochrane Library, and Lilacs 
      databases were searched. Studies that reported an association between PPI use and 
      CKD or End-stage Renal Disease (ESRD) published until December 23, 2019, were 
      included. All selected studies present high quality according to the 
      New-Castle-Ottawa. The risk ratio (RR) and confidence interval (CI) were pooled 
      using a random-effects model in CKD outcome analysis and fixed effects model for 
      ESRD. A total of 10 observational studies were selected. EVIDENCE SYNTHESIS: 
      Compared to patients who did not use PPI, the RR for CKD associated with PPI use 
      was 1.35 (95% CI 1.15-1.56) with P<0.001, and the RR for ESRD associated with PPI 
      use was 1.49 (95% CI 1.41-1.56) with P<0.001. CONCLUSIONS: This study indicates 
      the presence of a significant association between PPI use and an increased risk 
      of CKD and ESRD and reiterates the need for the medical prescription of this 
      class of drugs to be made following the guidelines of the FDA.
FAU - Vengrus, Carolina S
AU  - Vengrus CS
AD  - School of Medicine, Pontifical Catholic University of Parana, Londrina, Brazil.
FAU - Delfino, Vinicius D
AU  - Delfino VD
AD  - School of Medicine, Pontifical Catholic University of Parana, Londrina, Brazil.
AD  - Universidade Estadual de Londrina, Londrina, Brazil.
FAU - Bignardi, Paulo R
AU  - Bignardi PR
AD  - School of Medicine, Pontifical Catholic University of Parana, Londrina, Brazil - 
      paulo.bignardi@pucpr.br.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210326
PL  - Italy
TA  - Minerva Urol Nephrol
JT  - Minerva urology and nephrology
JID - 101777299
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Databases, Factual
MH  - Humans
MH  - *Kidney Failure, Chronic/chemically induced
MH  - Odds Ratio
MH  - Proton Pump Inhibitors/adverse effects
MH  - *Renal Insufficiency, Chronic/chemically induced
EDAT- 2021/03/27 06:00
MHDA- 2021/11/26 06:00
CRDT- 2021/03/26 11:20
PHST- 2021/03/27 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/03/26 11:20 [entrez]
AID - S2724-6051.21.04116-3 [pii]
AID - 10.23736/S2724-6051.21.04116-3 [doi]
PST - ppublish
SO  - Minerva Urol Nephrol. 2021 Aug;73(4):462-470. doi: 
      10.23736/S2724-6051.21.04116-3. Epub 2021 Mar 26.