PMID- 33772293
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 2042-7158 (Electronic)
IS  - 0022-3573 (Linking)
VI  - 73
IP  - 5
DP  - 2021 Mar 27
TI  - A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and 
      anxiogenic-like effects of a high-fat/high-fructose diet in mice.
PG  - 673-681
LID - 10.1093/jpp/rgaa070 [doi]
AB  - OBJECTIVE: While chronic feeding with high-fat or high-sugar diets is known 
      related to obesity and type 2 diabetes, later data have indicated that it is also 
      related to depression and anxiety appearance. In this regard, multi-target drugs 
      raise considerable interest as promising therapeutic solutions to complex 
      diseases. Considering the pharmacological effects of the 
      imidazopyridine-derivative moiety imidazo[1,2-a]pyridine and the organoselenium 
      molecules, the combination of both could be a feasible strategy to develop 
      efficient drugs to handle obesity and related comorbidities, for example 
      dyslipidemia and mood disorders. METHODS: The antidepressant- and anxiolytic-like 
      properties of a selanylimidazopyridine compound, 
      2-Phenyl-3-(phenylselanyl)imidazo[1,2-a]pyridine (3-SePh-IP), were evaluated on 
      high-fat/high-fructose diet (HFFD)-fed female Swiss mice. KEY FINDINGS: Our 
      results showed that a short-term HFFD (16 days) could promote a significant body 
      weight gain, hypercholesterolemia, glucose intolerance, and anxiety- and 
      depressive-like behaviour in mice. Concomitant treatment with 3-SePh-IP (10 
      mg/kg; i.p.) attenuated the HFFD-induced increase in cholesterol levels and 
      blunted the anxiety- and depressive-like behaviour in mice. CONCLUSIONS: 
      3-SePh-IP holds multimodal pharmacological properties, which provide a rationale 
      for further studies, for example to assess the underlying mechanisms linked to 
      its anxiolytic- and antidepressive-like activities.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the Royal 
      Pharmaceutical Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Veloso, Izolene Correa
AU  - Veloso IC
AD  - Programa de Pos-Graduacao em Neurociencias, Universidade Federal de Santa 
      Catarina, Florianopolis, SC, Brazil.
FAU - Delanogare, Eslen
AU  - Delanogare E
AD  - Programa de Pos-Graduacao em Neurociencias, Universidade Federal de Santa 
      Catarina, Florianopolis, SC, Brazil.
FAU - Machado, Adriano Emanuel
AU  - Machado AE
AD  - Programa de Pos-Graduacao em Neurociencias, Universidade Federal de Santa 
      Catarina, Florianopolis, SC, Brazil.
FAU - Braga, Sara Pereira
AU  - Braga SP
AD  - Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Universidade 
      Federal de Santa Catarina, Florianopolis, SC, Brazil.
FAU - Rosa, Giovana Karoline
AU  - Rosa GK
AD  - Departamento de Ciencias Fisiologicas, Universidade Federal de Santa Catarina, 
      Florianopolis, SC, Brazil.
FAU - De Bem, Andreza Fabro
AU  - De Bem AF
AD  - Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, 
      Universidade de Brasilia, Brasilia, DF, Brazil.
FAU - Rafique, Jamal
AU  - Rafique J
AD  - Instituto de Quimica, Universidade Federal do Mato Grosso do Sul, Campo Grande, 
      MS, Brazil.
FAU - Saba, Sumbal
AU  - Saba S
AD  - Centro de Ciencias Naturais e Humanas - CCNH, Universidade Federal do ABC, Santo 
      Andre, SP, Brazil.
FAU - da Trindade, Roberth Nascimento
AU  - da Trindade RN
AD  - Departamento de Quimica, Universidade Federal de Santa Catarina, Florianopolis, 
      SC, Brazil.
FAU - Galetto, Fabio Zazyki
AU  - Galetto FZ
AD  - Departamento de Quimica, Universidade Federal de Santa Catarina, Florianopolis, 
      SC, Brazil.
FAU - Moreira, Eduardo Luiz Gasnhar
AU  - Moreira ELG
AD  - Departamento de Ciencias Fisiologicas, Universidade Federal de Santa Catarina, 
      Florianopolis, SC, Brazil.
AD  - Programa de Pos-Graduacao em Neurociencias, Universidade Federal de Santa 
      Catarina, Florianopolis, SC, Brazil.
AD  - Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Universidade 
      Federal de Santa Catarina, Florianopolis, SC, Brazil.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Imidazoles)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (Pyridines)
RN  - 0 (imidazopyridine)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Animals
MH  - Anxiety/chemically induced/*drug therapy
MH  - Behavior, Animal/drug effects
MH  - Depression/chemically induced/*drug therapy
MH  - Diet, High-Fat/*adverse effects
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fructose/*adverse effects
MH  - Hindlimb Suspension
MH  - Imidazoles/*pharmacology
MH  - Mice
MH  - Organoselenium Compounds/*pharmacology
MH  - Pyridines/*pharmacology
MH  - Weight Gain/drug effects
OTO - NOTNLM
OT  - behavioural
OT  - imidazopyridine
OT  - obesity
OT  - selenium
EDAT- 2021/03/28 06:00
MHDA- 2021/11/09 06:00
CRDT- 2021/03/27 06:23
PHST- 2020/06/17 00:00 [received]
PHST- 2020/12/23 00:00 [accepted]
PHST- 2021/03/27 06:23 [entrez]
PHST- 2021/03/28 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
AID - 6156912 [pii]
AID - 10.1093/jpp/rgaa070 [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 2021 Mar 27;73(5):673-681. doi: 10.1093/jpp/rgaa070.