PMID- 33773095 OWN - NLM STAT- MEDLINE DCOM- 20210702 LR - 20210702 IS - 2055-5822 (Electronic) IS - 2055-5822 (Linking) VI - 8 IP - 3 DP - 2021 Jun TI - Health-related quality of life in left ventricular assist device-supported patients. PG - 2036-2044 LID - 10.1002/ehf2.13282 [doi] AB - AIMS: This study aimed to evaluate the different health-related quality of life (HR-QoL) aspects in patients with both short-term and long-term duration LVAD support at pre-specified time intervals. METHODS AND RESULTS: We performed a single-centre HR-QoL analysis of short-term and long-term LVAD-supported patients using the short version of the Kansas City Cardiomyopathy Questionnaire (KCCQ-12) and the Changes in Sexual Functioning Questionnaire along with a survey to evaluate patients' social and driving routines. Data were collected at baseline and at 6 or 12 month follow-up. Included were 46 patients with a median time from LVAD implantation of 1.1 [inter-quartile range (IQR) 0.5, 2.6] years. The median KCCQ-12 summary score was 56 (IQR 29, 74) with most favourable scores in the symptom frequency domain [75 (IQR 50, 92)] and worse scores in the physical limitation [42 (IQR 25, 75)] and QoL [44 (IQR 25, 75)] domains. No significant changes were apparent during study follow-up [KCCQ-12 summary score 56 (IQR 35, 80)], and no significant correlation between the KCCQ-12 summary score and ventricular assist device-support duration was detected (r = -0.036, P = 0.812). Sexual dysfunction was noted across all domains with a cumulative score of 31 (IQR 22, 42). Seventy-six per cent of patients resumed driving after LVAD implantation, and 43% of patients reported they socialize with family and friends more frequently since surgery. CONCLUSIONS: Short-term and long-term LVAD-supported patients had impaired HR-QoL and sexual function at baseline and at follow-up yet reported an improvement in social interactions and independency. A broader spectrum of patient's reported HR-QoL measures should be integrated into the pre-LVAD implantation assessment and preparation. CI - (c) 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. FAU - Itzhaki Ben Zadok, Osnat AU - Itzhaki Ben Zadok O AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Ben-Avraham, Binyamin AU - Ben-Avraham B AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Jaarsma, Tiny AU - Jaarsma T AD - Department of Nursing Science, Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands. AD - Department of Medicine, Health and Care, Faculty of Medicine and Health Sciences, Linkoping University, Linkoping, Sweden. FAU - Shaul, Aviv AU - Shaul A AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Hammer, Yoav AU - Hammer Y AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Barac, Yaron D AU - Barac YD AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Cardio-Thoracic Surgery, Rabin Medical Center, Petah Tikva, Israel. FAU - Mats, Israel AU - Mats I AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Eldar, Orit AU - Eldar O AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. FAU - Abuhazira, Miriam AU - Abuhazira M AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Cardio-Thoracic Surgery, Rabin Medical Center, Petah Tikva, Israel. FAU - Yaari, Vicky AU - Yaari V AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Gulobov, Dmitry AU - Gulobov D AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Cardio-Thoracic Surgery, Rabin Medical Center, Petah Tikva, Israel. FAU - Mulu, Mastwal AU - Mulu M AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. FAU - Aravot, Dan AU - Aravot D AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Cardio-Thoracic Surgery, Rabin Medical Center, Petah Tikva, Israel. FAU - Kornowski, Ran AU - Kornowski R AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Ben-Gal, Tuvia AU - Ben-Gal T AD - Department of Cardiology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva, 49100, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. LA - eng PT - Journal Article DEP - 20210327 PL - England TA - ESC Heart Fail JT - ESC heart failure JID - 101669191 SB - IM MH - Follow-Up Studies MH - *Heart Failure/therapy MH - *Heart-Assist Devices MH - Humans MH - Quality of Life MH - Treatment Outcome PMC - PMC8120365 OTO - NOTNLM OT - Heart failure OT - Left ventricular assist devices OT - Quality of life OT - Sexual dysfunction COIS- None declared. EDAT- 2021/03/28 06:00 MHDA- 2021/07/03 06:00 PMCR- 2021/03/27 CRDT- 2021/03/27 17:45 PHST- 2021/02/01 00:00 [revised] PHST- 2020/12/20 00:00 [received] PHST- 2021/02/12 00:00 [accepted] PHST- 2021/03/28 06:00 [pubmed] PHST- 2021/07/03 06:00 [medline] PHST- 2021/03/27 17:45 [entrez] PHST- 2021/03/27 00:00 [pmc-release] AID - EHF213282 [pii] AID - 10.1002/ehf2.13282 [doi] PST - ppublish SO - ESC Heart Fail. 2021 Jun;8(3):2036-2044. doi: 10.1002/ehf2.13282. Epub 2021 Mar 27.