PMID- 33774542
OWN - NLM
STAT- MEDLINE
DCOM- 20210531
LR  - 20210531
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 280
DP  - 2021 Jul 1
TI  - Aerobic exercise ameliorates particulate matter-induced lung injury in aging 
      rats.
PG  - 116889
LID - S0269-7491(21)00471-1 [pii]
LID - 10.1016/j.envpol.2021.116889 [doi]
AB  - Particulate matter 2.5 (PM(2.5)) is an inflammatory-inducing factor that is 
      considered to be related to many adverse respiratory problems, especially in the 
      elderly. This study aimed to examine whether pre-exercise training could prevent 
      pulmonary injury induced by urban PM(2.5) in aging rats and investigate its 
      relationship with inflammatory pathways. Male Wistar rats (aged 16 months) were 
      randomly divided into four groups: sedentary, exercise, sedentary + PM(2.5) 
      exposure, and exercise + PM(2.5) exposure. All rats in exercise-related groups 
      were treadmill-trained for 8 weeks (65%-75% VO(2max) for 30 min every other day). 
      Sedentary groups' rats lived freely in cages without exercise intervention. Rats 
      in the PM-related groups were exposed to ambient PM(2.5) (4 h day(-1)) for 2 
      weeks after an 8-week exercise intervention or sedentary treatment. Finally, all 
      rats' pulmonary function, lung morphology, degree of inflammation, and relevant 
      protein and mRNA transcript expression levels were examined. The results 
      indicated that PM(2.5) exposure induced lung injury in the sedentary + PM(2.5) 
      exposure group, as evidenced by the deterioration of pulmonary function, 
      histopathological characteristics, and inflammatory changes. Aerobic exercise 
      alleviated PM(2.5)-induced airway obstruction, deterioration of pulmonary 
      function, bronchial mucosal exfoliation, and inflammatory responses in aging 
      rats. These effects in exercise groups were associated with the increased 
      expression of intracellular 70 kDa heat shock protein (iHSP70) and the 
      suppression of nuclear transcription factor-kappaB (NF-kappaB) activation, as confirmed 
      by increased expression of inhibitor of NF-kappaB (IkappaBalpha) and a reduction in 
      phospho-IKBalpha (p-IkappaBalpha), which is regulated by inhibiting kappa B kinase beta 
      (IKKbeta). Taken together, aerobic pre-exercise had protective effects on lung 
      injury and reduced vulnerability to inflammation induced by PM(2.5) exposure, 
      possibly through the toll-like receptor 4 (TLR4)/NF-kappaB signaling pathways 
      mediated by the extracellular-to-intracellular HSP70 ratio. Pre-exercise training 
      may be an effective way to protect against PM(2.5)-induced lung toxicity in aging 
      individuals.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Qin, Fei
AU  - Qin F
AD  - China Institute of Sport Science, Beijing, China; School of Physical Education, 
      Jinan University, Guangzhou, China.
FAU - Cui, Shuqiang
AU  - Cui S
AD  - Beijing Research Institute of Sports Science, Beijing, China.
FAU - Dong, Yanan
AU  - Dong Y
AD  - Beijing Research Institute of Sports Science, Beijing, China.
FAU - Xu, Minxiao
AU  - Xu M
AD  - China Institute of Sport Science, Beijing, China; Shanghai University of Sport, 
      Shanghai, China.
FAU - Wang, Zhongwei
AU  - Wang Z
AD  - China Institute of Sport Science, Beijing, China; Changzhou Research Institute of 
      Science and Medical Treatment, Changzhou, China.
FAU - Qu, Chaoyi
AU  - Qu C
AD  - China Institute of Sport Science, Beijing, China.
FAU - Zhao, Jiexiu
AU  - Zhao J
AD  - China Institute of Sport Science, Beijing, China. Electronic address: 
      zhaojiexiu@ciss.cn.
LA  - eng
PT  - Journal Article
DEP - 20210310
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (NF-kappa B)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Lung
MH  - *Lung Injury/chemically induced/prevention & control
MH  - Male
MH  - NF-kappa B
MH  - *Particulate Matter/toxicity
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - HSP70
OT  - Inflammation
OT  - PM(2.5) exposures
OT  - Pre-exercise
EDAT- 2021/03/29 06:00
MHDA- 2021/06/01 06:00
CRDT- 2021/03/28 20:58
PHST- 2020/09/17 00:00 [received]
PHST- 2021/03/05 00:00 [revised]
PHST- 2021/03/06 00:00 [accepted]
PHST- 2021/03/29 06:00 [pubmed]
PHST- 2021/06/01 06:00 [medline]
PHST- 2021/03/28 20:58 [entrez]
AID - S0269-7491(21)00471-1 [pii]
AID - 10.1016/j.envpol.2021.116889 [doi]
PST - ppublish
SO  - Environ Pollut. 2021 Jul 1;280:116889. doi: 10.1016/j.envpol.2021.116889. Epub 
      2021 Mar 10.