PMID- 3377603
OWN - NLM
STAT- MEDLINE
DCOM- 19880705
LR  - 20161020
IS  - 0235-2990 (Print)
IS  - 0235-2990 (Linking)
VI  - 33
IP  - 2
DP  - 1988 Feb
TI  - [Effectiveness of prodigiozan, methyluracil and levamisole in experimental 
      infection after administration of non-steroidal anti-inflammatory drugs].
PG  - 131-4
AB  - The effect of nonsteroid antiinflammatory drugs (NAID) such as voltaren, 
      acetylsalicylic acid, indometacin and naproxen on the efficacy of 
      immunostimulators in treatment of infections caused by Proteus and Staphylococcus 
      was studied. It was shown that except naproxen the NAID were capable of 
      decreasing resistance to Proteus infections. Acetylsalicylic acid increased 
      resistance to staphylococcal infections. The rest of the drugs did not change it. 
      Prodigiozan increased resistance to the infections at the background of the NAID. 
      However, volteran and indometacin lowered its effect in infections caused by 
      Proteus. Levamisol stimulated resistance of mice to the infections at the 
      background of volteran and increased resistance to Proteus infections lowered by 
      acetylsalicylic acid. Methyluracyl was not able to increase resistance to the 
      infections at the background of the NAID. It only increased resistance to Proteus 
      infections lowered by acetylsalicylic acid. Levamisol and methyluracyl did not as 
      a rule increase efficacy of antibiotic therapy at the background of the NAID.
FAU - Bogdanova, A Sh
AU  - Bogdanova ASh
FAU - Lazareva, D N
AU  - Lazareva DN
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Effektivnost' prodigiozana, metiluratsila, levamizola pri eksperimental'noi 
      infektsii na fone primeneniia nesteroidnykh protivovospalitel'nykh sredstv.
PL  - Russia (Federation)
TA  - Antibiot Khimioter
JT  - Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]
JID - 8803688
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Polysaccharides, Bacterial)
RN  - 2880D3468G (Levamisole)
RN  - 56HH86ZVCT (Uracil)
RN  - 5O052W0G6I (6-methyluracil)
RN  - 9057-00-5 (Prodigiozan)
SB  - IM
MH  - Adjuvants, Immunologic
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Drug Interactions
MH  - Drug Therapy, Combination
MH  - Female
MH  - Levamisole/*therapeutic use
MH  - Male
MH  - Mice
MH  - Polysaccharides, Bacterial/*therapeutic use
MH  - Prodigiozan/*therapeutic use
MH  - Proteus Infections/*drug therapy/immunology
MH  - Uracil/*analogs & derivatives/therapeutic use
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
PST - ppublish
SO  - Antibiot Khimioter. 1988 Feb;33(2):131-4.