PMID- 33776456
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 1178-6973 (Print)
IS  - 1178-6973 (Electronic)
IS  - 1178-6973 (Linking)
VI  - 14
DP  - 2021
TI  - The Value of Nutritional Status in the Prognostic Analysis of Patients with 
      AIDS-Related Lymphoma.
PG  - 1105-1113
LID - 10.2147/IDR.S295077 [doi]
AB  - OBJECTIVE: Many studies have suggested that indexes of nutritional status, such 
      as body mass index (BMI), serum albumin (ALB), serum pre-albumin (PA), and 
      hemoglobin, may be used as risk factors for the prognosis of HIV or lymphoma. 
      Therefore, this study aimed to retrospectively analyze and explore the value of 
      nutritional status in the prognostic assessment of patients with AIDS-related 
      lymphoma (ARL). METHODS: In this retrospective study, the clinical data of 69 
      patients with ARL were collected. All patients had a definite diagnosis of 
      non-Hodgkin lymphoma by pathological examination and met the requirements of the 
      Hematopoietic and Lymphocytic Tissue Tumor Classification (2016) established by 
      the World Health Organization. Patients who did not receive standard 
      chemotherapy, those with incomplete medical records, and those with an unclear 
      pathological diagnosis were excluded. The patients were divided into two groups 
      (survival and death) according to the prognostic outcome, and their clinical 
      characteristics and prognoses were discussed by relevant statistical methods. 
      RESULTS: During the three-year follow-up period, 20 (28.99%) patients died, and 
      49 (71.01%) survived. The one-year cumulative survival rate was 78.26%. A 
      univariate analysis found that the prognosis was associated with the 
      International Prognostic Index (IPI) score, BMI, ALB, PA, and CD4 T lymphocyte 
      count. The Cox risk proportional regression analysis showed that the IPI score, 
      BMI, and PA were the independent risk factors for survival; their combination had 
      a greater ability to forecast the clinical outcome (area under the curve = 0.874, 
      P < 0.001). CONCLUSION: In this study, at the time of the visit, the patients 
      with ARL tended to be in the advanced stages of disease and, therefore, at high 
      risk of mortality. Therefore, their nutritional status might be of great value to 
      the prognostic assessment. The combination of BMI, PA, and IPI scores could be 
      used for risk stratification and better screening of high-risk patients.
CI  - (c) 2021 Sun et al.
FAU - Sun, Yanbo
AU  - Sun Y
AD  - Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, 650101, People's Republic of China.
FAU - Luo, Jing
AU  - Luo J
AD  - Department of Gastrointestinal Surgery, The First People's Hospital of Qujing, 
      Qujing, 655000, People's Republic of China.
FAU - Qian, Chuan
AU  - Qian C
AD  - The Second Department of Infection, Yunnan Provincial Infectious Disease 
      Hospital, Kunming, 650301, People's Republic of China.
FAU - Luo, Lan
AU  - Luo L
AD  - The Second Department of Infection, Yunnan Provincial Infectious Disease 
      Hospital, Kunming, 650301, People's Republic of China.
FAU - Xu, Manqi
AU  - Xu M
AD  - Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, 650101, People's Republic of China.
FAU - Min, Haiyan
AU  - Min H
AD  - The Second Department of Infection, Yunnan Provincial Infectious Disease 
      Hospital, Kunming, 650301, People's Republic of China.
FAU - Cen, Yunyun
AU  - Cen Y
AD  - Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, 650101, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210318
PL  - New Zealand
TA  - Infect Drug Resist
JT  - Infection and drug resistance
JID - 101550216
PMC - PMC7987257
OTO - NOTNLM
OT  - AIDS-related lymphoma
OT  - body mass index
OT  - pre-albumin
OT  - prognostic factor
OT  - retrospective analysis
COIS- The authors declare that they have no competing interests.
EDAT- 2021/03/30 06:00
MHDA- 2021/03/30 06:01
PMCR- 2021/03/18
CRDT- 2021/03/29 06:18
PHST- 2020/12/16 00:00 [received]
PHST- 2021/02/24 00:00 [accepted]
PHST- 2021/03/29 06:18 [entrez]
PHST- 2021/03/30 06:00 [pubmed]
PHST- 2021/03/30 06:01 [medline]
PHST- 2021/03/18 00:00 [pmc-release]
AID - 295077 [pii]
AID - 10.2147/IDR.S295077 [doi]
PST - epublish
SO  - Infect Drug Resist. 2021 Mar 18;14:1105-1113. doi: 10.2147/IDR.S295077. 
      eCollection 2021.