PMID- 33776922 OWN - NLM STAT- MEDLINE DCOM- 20211216 LR - 20211216 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 12 DP - 2021 TI - Vascular Endothelial Function as a Valid Predictor of Variations in Pulmonary Function in T2DM Patients Without Related Complications. PG - 622768 LID - 10.3389/fendo.2021.622768 [doi] LID - 622768 AB - To assess the variations in pulmonary function and vascular endothelial function in their early stages (without related complications). A total of 162 type 2 diabetes mellitus (T2DM) patients without diabetes complications and 55 healthy people were selected, comprising the T2DM group and the control group, respectively, to evaluate changes in vascular endothelial function and lung function and determine the correlation between them. In this study, the T2DM group exhibited significantly lower pulmonary function than that of the control group (P < 0.05). The T2DM group also showed significantly lower flow-mediated dilation (FMD) and nitric oxide (NO) (P < 0.05) than those of the control group. Pulmonary functional indexes correlated positively with FMD and NO (P < 0.05) and correlated negatively with endothelin-1 (ET-1) (P < 0.05). FMD and NO correlated negatively with diabetes duration/HbA1c (P < 0.05), whereas ET-1 correlated positively with glycosylated hemoglobinA1c (HbA1c)/diabetes duration (P < 0.05). Pulmonary functional indexes negatively correlated with HbA1c/diabetes duration (P < 0.05). Multiple linear regression was used to analyze the relationship between vascular endothelial function indexes (FMD, ET-1, and NO) and pulmonary functional indexes. The results indicated that each vascular endothelial function index (FMD, ET-1, and NO) was significantly correlated with the pulmonary functional index (P < 0.05). The patients with T2DM presented changes in the subclinical vascular endothelial and pulmonary function. They also had impaired vascular endothelial functions, which were characterized by reduced vascular endothelial function relative to those of healthy people. Regulating glycemia may improve vascular endothelial and pulmonary functions. Moreover, microvascular lesions in preclinical stages, vascular endothelial function indexes (FMD, ET-1, and NO) were valid predictors of alterations in pulmonary function in T2DM patients without related complications. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT03575988. CI - Copyright (c) 2021 Tai, Jiang, Yao, Liu, Wei, Li, Jiao, Wang, Kuang and Jia. FAU - Tai, He AU - Tai H AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application, Liaoning University of Traditional Chinese Medicine, Shenyang, China. AD - Department of Endocrinology and Metabolic, Liaoning Provincial Corps Hospital of Chinese People's Armed Police Forces, Shenyang, China. FAU - Jiang, Xiao-Lin AU - Jiang XL AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application, Liaoning University of Traditional Chinese Medicine, Shenyang, China. AD - Department of Medical Laboratory, The Fourth of Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (Shenzhen Traditional Chinese Medicine Hospital), Guangzhou University of Traditional Chinese Medicine, Dalian, China. FAU - Yao, Si-Cheng AU - Yao SC AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application, Liaoning University of Traditional Chinese Medicine, Shenyang, China. FAU - Liu, Ye AU - Liu Y AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application, Liaoning University of Traditional Chinese Medicine, Shenyang, China. FAU - Wei, Hong AU - Wei H AD - Department of Echocardiography, The First Affiliated Hospital of Dalian Medical University, Beijing, China. FAU - Li, Ling-Bing AU - Li LB AD - Department of Graduate School, China PLA General Hospital, Shenyang, China. FAU - Jiao, Zeng-Jin AU - Jiao ZJ AD - Department of Geriatrics, The Affiliated Hospital of Liaoning Traditional Chinese Medicine, Shenyang, China. FAU - Wang, Tian-Qing AU - Wang TQ AD - Department of Clinical Nutrition, The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China. FAU - Kuang, Jin-Song AU - Kuang JS AD - Department of Endocrinology and Metabolic, Shenyang the Fourth Hospital of People, Shenyang, China. FAU - Jia, Lian-Qun AU - Jia LQ AD - Key Laboratory of Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application, Liaoning University of Traditional Chinese Medicine, Shenyang, China. LA - eng SI - ClinicalTrials.gov/NCT03575988 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210311 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Blood Glucose) RN - 0 (Endothelin-1) RN - 31C4KY9ESH (Nitric Oxide) SB - IM MH - Adult MH - *Blood Glucose MH - Diabetes Mellitus, Type 2/blood/*physiopathology MH - Endothelin-1/blood MH - Endothelium, Vascular/*physiopathology MH - Female MH - Humans MH - Lung/*physiopathology MH - Male MH - Middle Aged MH - Nitric Oxide/blood PMC - PMC7991996 OTO - NOTNLM OT - early stage OT - predictor OT - pulmonary function OT - type 2 diabetes mellitus OT - vascular endothelial function COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/03/30 06:00 MHDA- 2021/12/17 06:00 PMCR- 2021/01/01 CRDT- 2021/03/29 06:24 PHST- 2020/10/29 00:00 [received] PHST- 2021/02/09 00:00 [accepted] PHST- 2021/03/29 06:24 [entrez] PHST- 2021/03/30 06:00 [pubmed] PHST- 2021/12/17 06:00 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2021.622768 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2021 Mar 11;12:622768. doi: 10.3389/fendo.2021.622768. eCollection 2021.