PMID- 33778363 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231114 IS - 2474-7882 (Electronic) IS - 2474-7882 (Linking) VI - 5 IP - 2 DP - 2021 Apr TI - Exposure to metal mixtures in relation to blood pressure among children 5-7 years old: An observational study in Bangladesh. PG - e135 LID - 10.1097/EE9.0000000000000135 [doi] LID - e135 AB - Hypertension in later life, a significant risk factor for cardiovascular disease, has been linked to elevated blood pressure in early life. Exposure to metals may influence childhood blood pressure; however, previous research is limited and has mainly focused on evaluating the toxicity of single metal exposures. This study evaluates the associations between exposure to metal mixtures and blood pressure among Bangladeshi children age 5-7 years. METHODS: We investigated the associations of 17 toenail metal concentrations with blood pressure using linear regression models. Principal component analysis (PCA), weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were conducted as secondary analyses. RESULTS: Associations were observed for selenium with diastolic blood pressure (per doubling of exposure beta = 2.91, 95% confidence interval [CI] = 1.08, 4.75), molybdenum with systolic (beta = 0.33, 95% CI = 0.05, 0.61) and diastolic blood pressure (beta = 0.39, 95% CI = 0.12, 0.66), tin with systolic blood pressure (beta = -0.33, 95% CI = -0.60, -0.06), and mercury with systolic (beta = -0.83, 95% CI = -1.49, -0.17) and diastolic blood pressure (beta = -0.89, 95% CI = -1.53, -0.26). Chromium was associated with diastolic blood pressure among boys only (beta = 1.10, 95% CI = 0.28, 1.92, P for interaction = 0.02), and copper was associated with diastolic blood pressure among girls only (beta = -1.97, 95% CI = -3.63, -0.32, P for interaction = 0.01). These findings were largely robust to the secondary analyses that utilized mixture modeling approaches (PCA, WQS, and BKMR). CONCLUSIONS: Future prospective studies are needed to investigate further the impact of early life exposure to metal mixtures on children's blood pressure trajectories and cardiovascular disease risk later in life. CI - Copyright (c) 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environment Epidemiology. All rights reserved. FAU - Shih, Yu-Hsuan AU - Shih YH AD - Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois. FAU - Howe, Caitlin G AU - Howe CG AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth College, Lebanon, New Hampshire. FAU - Scannell Bryan, Molly AU - Scannell Bryan M AD - Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois. AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth College, Lebanon, New Hampshire. AD - Institute for Minority Health Research, College of Medicine, University of Illinois Chicago, Chicago, Illinois. AD - UChicago Research Bangladesh, Dhaka, Bangladesh. AD - Department of Public Health Sciences, University of Chicago, Chicago, Illinois. AD - Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York. AD - Trace Element Analysis Core Laboratory, Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire. AD - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. FAU - Shahriar, Mohammad AU - Shahriar M AD - UChicago Research Bangladesh, Dhaka, Bangladesh. FAU - Kibriya, Muhammad G AU - Kibriya MG AD - Department of Public Health Sciences, University of Chicago, Chicago, Illinois. FAU - Jasmine, Farzana AU - Jasmine F AD - Department of Public Health Sciences, University of Chicago, Chicago, Illinois. FAU - Sarwar, Golam AU - Sarwar G AD - UChicago Research Bangladesh, Dhaka, Bangladesh. FAU - Graziano, Joseph H AU - Graziano JH AD - Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York. FAU - Persky, Victoria W AU - Persky VW AD - Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois. FAU - Jackson, Brian AU - Jackson B AD - Trace Element Analysis Core Laboratory, Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire. FAU - Ahsan, Habibul AU - Ahsan H AD - Department of Public Health Sciences, University of Chicago, Chicago, Illinois. FAU - Farzan, Shohreh F AU - Farzan SF AD - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. FAU - Argos, Maria AU - Argos M AD - Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois. LA - eng GR - K99 ES030400/ES/NIEHS NIH HHS/United States GR - P30 CA023108/CA/NCI NIH HHS/United States GR - R00 ES024144/ES/NIEHS NIH HHS/United States GR - R01 ES024423/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20210211 PL - United States TA - Environ Epidemiol JT - Environmental epidemiology (Philadelphia, Pa.) JID - 101719527 PMC - PMC7939402 OTO - NOTNLM OT - Bangladesh OT - Blood pressure OT - Child health OT - Metal mixtures COIS- The authors declare that they have no conflicts of interest with regard to the content of this report.Sponsorships or competing interests that may be relevant to content are disclosed at the end of the article. EDAT- 2021/03/30 06:00 MHDA- 2021/03/30 06:01 PMCR- 2021/02/11 CRDT- 2021/03/29 06:41 PHST- 2020/09/09 00:00 [received] PHST- 2021/01/15 00:00 [accepted] PHST- 2021/03/29 06:41 [entrez] PHST- 2021/03/30 06:00 [pubmed] PHST- 2021/03/30 06:01 [medline] PHST- 2021/02/11 00:00 [pmc-release] AID - 10.1097/EE9.0000000000000135 [doi] PST - epublish SO - Environ Epidemiol. 2021 Feb 11;5(2):e135. doi: 10.1097/EE9.0000000000000135. eCollection 2021 Apr.