PMID- 33778734
OWN - NLM
STAT- MEDLINE
DCOM- 20210825
LR  - 20211204
IS  - 2638-616X (Electronic)
IS  - 2638-616X (Linking)
VI  - 2
IP  - 5
DP  - 2020 Sep
TI  - mTOR Inhibitor Therapy for Tuberous Sclerosis Complex: Longitudinal Study of 
      Muscle Mass Determined by Abdominal Cross-sectional Imaging with CT and MRI.
PG  - e190091
LID - 10.1148/rycan.2020190091 [doi]
LID - e190091
AB  - PURPOSE: To determine the effect of chronic mammalian target of rapamycin (mTOR) 
      inhibition on skeletal muscle mass in patients with tuberous sclerosis complex 
      (TSC). MATERIALS AND METHODS: In this retrospective study, patients with TSC who 
      were taking mTOR inhibitors and who underwent at least two abdominal CT or MRI 
      examinations between 2005 and 2017 were included (n = 24; 14 males; mean age, 
      14.5 years +/- 7.8 [standard deviation] at first examination). One reviewer drew 
      regions of interest around psoas muscles at L3 to measure cross-sectional area. 
      Multiple linear mixed-effect modeling was performed to evaluate the association 
      between muscle mass and the covariates over time. RESULTS: The 24 patients 
      underwent a total of 129 abdominal CT or MRI examinations. Median duration of 
      mTOR inhibition at last examination was 106 months (range, 1310-3717 days). There 
      was no significant association between the duration of mTOR inhibitor therapy and 
      psoas muscle area on multiple linear mixed-effect modeling (P = .055); however, 
      patient height and height squared were significant predictors of psoas area (P = 
      .014 and P < .0001, respectively). CONCLUSION: Duration of mTOR inhibition in TSC 
      was not significantly associated with a decrease in psoas muscle area, suggesting 
      that chronic mTOR inhibition is not associated with sarcopenia.Keywords: CT, 
      MR-Imaging, Pediatrics(c) RSNA, 2020.
CI  - 2020 by the Radiological Society of North America, Inc.
FAU - Raab, Caroline
AU  - Raab C
AD  - Department of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); 
      Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., 
      D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati 
      Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 
      45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., 
      D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
FAU - Gilligan, Leah A
AU  - Gilligan LA
AUID- ORCID: 0000-0002-4632-7004
AD  - Department of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); 
      Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., 
      D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati 
      Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 
      45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., 
      D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
FAU - Trout, Andrew T
AU  - Trout AT
AUID- ORCID: 0000-0003-1431-4054
AD  - Department of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); 
      Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., 
      D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati 
      Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 
      45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., 
      D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
FAU - Krueger, Darcy A
AU  - Krueger DA
AD  - Department of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); 
      Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., 
      D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati 
      Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 
      45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., 
      D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
FAU - Franz, David N
AU  - Franz DN
AD  - Department of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); 
      Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., 
      D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati 
      Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 
      45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., 
      D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
FAU - Zhang, Bin
AU  - Zhang B
AUID- ORCID: 0000-0003-0607-1806
AD  - Department of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); 
      Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., 
      D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati 
      Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 
      45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., 
      D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
FAU - Towbin, Alexander J
AU  - Towbin AJ
AUID- ORCID: 0000-0003-1729-5071
AD  - Department of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); 
      Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., 
      D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati 
      Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 
      45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., 
      D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
LA  - eng
PT  - Journal Article
DEP - 20200918
PL  - United States
TA  - Radiol Imaging Cancer
JT  - Radiology. Imaging cancer
JID - 101765309
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Psoas Muscles/*diagnostic imaging
MH  - Retrospective Studies
MH  - TOR Serine-Threonine Kinases/*antagonists & inhibitors
MH  - Tomography, X-Ray Computed
MH  - *Tuberous Sclerosis/diagnostic imaging/drug therapy
PMC - PMC7983794
EDAT- 2021/03/30 06:00
MHDA- 2021/08/26 06:00
PMCR- 2020/09/18
CRDT- 2021/03/29 06:45
PHST- 2019/11/13 00:00 [received]
PHST- 2020/05/03 00:00 [revised]
PHST- 2020/05/13 00:00 [accepted]
PHST- 2021/03/29 06:45 [entrez]
PHST- 2021/03/30 06:00 [pubmed]
PHST- 2021/08/26 06:00 [medline]
PHST- 2020/09/18 00:00 [pmc-release]
AID - 10.1148/rycan.2020190091 [doi]
PST - epublish
SO  - Radiol Imaging Cancer. 2020 Sep 18;2(5):e190091. doi: 10.1148/rycan.2020190091. 
      eCollection 2020 Sep.