PMID- 33779801
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20220218
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Print)
IS  - 0941-4355 (Linking)
VI  - 29
IP  - 10
DP  - 2021 Oct
TI  - Prognostic factors in patients with advanced cancer and COVID-19: a cohort from 
      the Palliative Care Unit of the Brazilian National Cancer Institute.
PG  - 6005-6012
LID - 10.1007/s00520-021-06149-1 [doi]
AB  - OBJECTIVE: To describe overall survival (OS) in 90 days and to evaluate the 
      prognostic factors in patients with advanced cancer and COVID-19. METHODS: This 
      is a retrospective cohort study carried out at the Palliative Care Unit of the 
      Brazilian National Cancer Institute. Patients with advanced cancer and COVID-19 
      confirmed by Reverse Transcription Polymerase Chain Reaction were included. 
      Kaplan-Meier's curves, log-rank test, and Cox regression were performed. RESULTS: 
      Eighty-three inpatients were selected. The average age was 61.4 (+/-12.6) years, 
      with a higher proportion of women (73.4%). The most prevalent tumor type was 
      breast (36.7%), followed by gastrointestinal tract (20.3%). The OS was 32 
      [interquartile range (IQR): 6-70] days, and at the end of the follow-up period, 
      17 patients (20.5%) were alive and 66 (79.5%) had died. Patients with advanced 
      cancer and COVID-19 and who were 60-74 years old [hazard ratio (HR): 2.03; 95% 
      confidence interval (CI): 1.09-3.78], with lung tumors (HR: 17.50; 95% CI: 
      1.70-28.34), with lung metastasis (HR: 4.21; 95% CI: 2.17-8.15), and with chronic 
      obstructive pulmonary disease (HR: 4.92; 95% CI: 1.01-24.69) had higher risk of 
      death in 90 days. CONCLUSION: The age of 60-74 years old, lung tumors (primary or 
      metastases), and the presence of chronic obstructive pulmonary disease were 
      considered independent prognostic factors in patients with advanced cancer and 
      COVID-19.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - de Oliveira, Livia Costa
AU  - de Oliveira LC
AUID- ORCID: 0000-0002-5052-1846
AD  - Palliative Care Unit, National Cancer Institute Jose Alencar Gomes da Silva 
      (INCA), Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, 
      20560-120114, Brazil. lillycostaoliveira@gmail.com.
FAU - da Costa Rosa, Karla Santos
AU  - da Costa Rosa KS
AD  - Palliative Care Unit, National Cancer Institute Jose Alencar Gomes da Silva 
      (INCA), Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, 
      20560-120114, Brazil.
FAU - Borsatto, Alessandra Zanei
AU  - Borsatto AZ
AD  - Palliative Care Unit, National Cancer Institute Jose Alencar Gomes da Silva 
      (INCA), Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, 
      20560-120114, Brazil.
FAU - de Oliveira, Luciana Aparecida Faria
AU  - de Oliveira LAF
AD  - Palliative Care Unit, National Cancer Institute Jose Alencar Gomes da Silva 
      (INCA), Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, 
      20560-120114, Brazil.
FAU - de Freitas, Renata
AU  - de Freitas R
AD  - Palliative Care Unit, National Cancer Institute Jose Alencar Gomes da Silva 
      (INCA), Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, 
      20560-120114, Brazil.
FAU - Dos Santos Machado Sampaio, Simone Garruth
AU  - Dos Santos Machado Sampaio SG
AD  - Palliative Care Unit, National Cancer Institute Jose Alencar Gomes da Silva 
      (INCA), Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, 
      20560-120114, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20210329
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Aged
MH  - *COVID-19
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - *Lung Neoplasms
MH  - Middle Aged
MH  - National Cancer Institute (U.S.)
MH  - Palliative Care
MH  - Prognosis
MH  - Retrospective Studies
MH  - SARS-CoV-2
MH  - United States
PMC - PMC8005668
OTO - NOTNLM
OT  - Advanced cancer
OT  - Coronavirus
OT  - Hospital mortality
OT  - Palliative care
OT  - Prognosis
COIS- The authors declare no competing interest.
EDAT- 2021/03/30 06:00
MHDA- 2021/10/16 06:00
PMCR- 2021/03/29
CRDT- 2021/03/29 13:36
PHST- 2020/12/16 00:00 [received]
PHST- 2021/03/11 00:00 [accepted]
PHST- 2021/03/30 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/03/29 13:36 [entrez]
PHST- 2021/03/29 00:00 [pmc-release]
AID - 10.1007/s00520-021-06149-1 [pii]
AID - 6149 [pii]
AID - 10.1007/s00520-021-06149-1 [doi]
PST - ppublish
SO  - Support Care Cancer. 2021 Oct;29(10):6005-6012. doi: 10.1007/s00520-021-06149-1. 
      Epub 2021 Mar 29.