PMID- 33780157
OWN - NLM
STAT- MEDLINE
DCOM- 20211130
LR  - 20211130
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 24
IP  - 5
DP  - 2021 May
TI  - Association of F11R polymorphisms and gene expression with primary Sjogren's 
      syndrome patients.
PG  - 681-686
LID - 10.1111/1756-185X.14095 [doi]
AB  - AIMS: F11R gene encodes junctional adhesion molecule-A protein (JAM-A), which is 
      expressed in various types of cells and is involved in leukocyte extravasation 
      during inflammation. Sjogren's syndrome (SS) is a chronic systemic inflammatory 
      disease that involves lymphocytes invasion of exocrine glands. F11R has been 
      studied in autoimmune diseases, but any association between F11R and SS has not 
      yet been investigated. Therefore, experiments were undertaken to examine the 
      relationships among F11R gene polymorphism, messenger RNA (mRNA) expression and 
      SS patients. METHODS: Three hundred and twenty-nine patients with SS, and 223 
      healthy controls were enrolled in their recruitment from the Kaohsiung Medical 
      University Hospital. Genomic DNA was extracted from peripheral blood mononuclear 
      cells and gene polymorphisms were genotyped by TaqMan real-time polymerase chain 
      reaction (PCR). F11R mRNA expression was quantitated by quantitative real-time 
      PCR with TaqMan Gene Expression Assay. RESULTS: Our study showed the genotype 
      -688A/C (rs6695707) was not found in relation to SS patients. The odds ratio of 
      -436A/G (rs12567886) genotype was notably associated with less susceptibility of 
      SS in human leukocyte antigen (HLA)-DR2 negative and HLA-DR3 negative 
      individuals. F11R mRNA expression was lower in SS patients than in the cells of 
      healthy controls. CONCLUSION: The result indicated that G allele of -436A/G 
      genotype has the potential protective effect against SS disease condition. F11R 
      mRNA was expressed significantly lower in SS patients.
CI  - (c) 2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Fang, Tzu-Jung
AU  - Fang TJ
AUID- ORCID: 0000-0002-7318-5152
AD  - Division of Geriatrics and Gerontology, Department of Internal Medicine, 
      Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
FAU - Li, Ruei-Nian
AU  - Li RN
AD  - Department of Biomedical Science and Environmental Biology, College of Life 
      Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Lin, Yuan-Zhao
AU  - Lin YZ
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
FAU - Lin, Chia-Hui
AU  - Lin CH
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
FAU - Tseng, Chia-Chun
AU  - Tseng CC
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
FAU - Sung, Wan-Yu
AU  - Sung WY
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
FAU - Ou, Tsan-Teng
AU  - Ou TT
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
FAU - Wu, Cheng-Chin
AU  - Wu CC
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
FAU - Yen, Jeng-Hsien
AU  - Yen JH
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
AD  - Institute of Medical Science and Technology, National Sun Yat-sen University, 
      Kaohsiung, Taiwan.
AD  - Department of Biological Science and Technology, National Chiao-Tung University, 
      Hsinchu, Taiwan.
LA  - eng
GR  - KMUH102-2M14/Kaohsiung Medical University Chung-Ho Memorial Hospital/
PT  - Journal Article
DEP - 20210329
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (F11R protein, human)
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - EC 2.7.7.- (Taq Polymerase)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Cell Adhesion Molecules/*genetics
MH  - Female
MH  - Gene Expression
MH  - Genotype
MH  - HLA-DR2 Antigen
MH  - HLA-DR3 Antigen
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - RNA, Messenger/*genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Cell Surface/*genetics
MH  - Sjogren's Syndrome/blood/diagnosis/*genetics/immunology
MH  - Taq Polymerase
EDAT- 2021/03/30 06:00
MHDA- 2021/12/01 06:00
CRDT- 2021/03/29 13:54
PHST- 2021/02/08 00:00 [revised]
PHST- 2020/10/29 00:00 [received]
PHST- 2021/02/18 00:00 [accepted]
PHST- 2021/03/30 06:00 [pubmed]
PHST- 2021/12/01 06:00 [medline]
PHST- 2021/03/29 13:54 [entrez]
AID - 10.1111/1756-185X.14095 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2021 May;24(5):681-686. doi: 10.1111/1756-185X.14095. Epub 2021 
      Mar 29.