PMID- 33781184
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20220531
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 28
IP  - 30
DP  - 2021
TI  - Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through 
      Modulation of the Nrf2/HO-1 and NF-kB Pathways.
PG  - 6287-6302
LID - 10.2174/0929867328666210329120213 [doi]
AB  - BACKGROUND: Vascular remodeling processes induced by acute and chronic injuries 
      are characterized by inflammation and oxidative stress. In arteriosclerosis, 
      atherosclerosis, and restenosis, the progression of neointimal hyperplasia is a 
      key event of vascular damage. OBJECTIVE: Our study was aimed to investigate the 
      inflammation and oxidative stress development during vascular impairment and the 
      potential efficacy of treatment of new micro composite 
      N-palmitoylethanolamine/Rutin at a ratio of 1:1 (PEA/RUT). The anti-inflammatory 
      effects of Palmitoylethanolamide (PEA) are well known. Rutin has important 
      pharmacological actions, including antioxidant and vasoprotective. METHODS: As a 
      model of vascular injury, we used the complete ligature of the left carotid 
      artery for fourteen days and administered PEA/RUT at the dose of 10 mg/Kg. 
      RESULTS: This study demonstrated that after fourteen days of carotid ligation, 
      there is a substantial structural change in the vessel morphology, with 
      inflammatory cell infiltration and reactive oxygen species production. PEA/RUT 
      administration reduced change in vascular morphology, cytokines like monocyte 
      chemoattractant protein-1 (MCP-1) and adhesion molecules expression like 
      intercellular adhesion molecules-1 (ICAM-1), proinflammatory cytokines production 
      (IL-1 beta, IL-6 and TNF- alpha), oxidative and nitrosative stress (nitrotyrosine and 
      PARP expression and NRF2 pathway). CONCLUSION: Our data clearly demonstrate the 
      beneficial effect of PEA/RUT administration in reducing inflammation, oxidative 
      stress, and vascular damage.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Fusco, Roberta
AU  - Fusco R
AD  - Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, n 31, Messina 98166, 
      Italy.
FAU - Siracusa, Rosalba
AU  - Siracusa R
AD  - Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, n 31, Messina 98166, 
      Italy.
FAU - Gugliandolo, Enrico
AU  - Gugliandolo E
AD  - Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, n 31, Messina 98166, 
      Italy.
FAU - Peritore, Alessio Filippo
AU  - Peritore AF
AD  - Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, n 31, Messina 98166, 
      Italy.
FAU - D'Amico, Ramona
AU  - D'Amico R
AD  - Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, n 31, Messina 98166, 
      Italy.
FAU - Cordaro, Marika
AU  - Cordaro M
AD  - Department of Biomedical, Dental and Morphological and Functional Imaging 
      University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
FAU - Crupi, Rosalia
AU  - Crupi R
AD  - Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
FAU - Impellizzeri, Daniela
AU  - Impellizzeri D
AD  - Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, n 31, Messina 98166, 
      Italy.
FAU - Gomiero, Chiara
AU  - Gomiero C
AD  - Epitech Research Group, Saccolongo, Padova, Italy.
FAU - Cuzzocrea, Salvatore
AU  - Cuzzocrea S
AD  - Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, n 31, Messina 98166, 
      Italy.
FAU - Di Paola, Rosanna
AU  - Di Paola R
AD  - Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, n 31, Messina 98166, 
      Italy.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Amides)
RN  - 0 (Ethanolamines)
RN  - 0 (Membrane Proteins)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NF-kappa B)
RN  - 0 (Palmitic Acids)
RN  - 5G06TVY3R7 (Rutin)
RN  - 6R8T1UDM3V (palmidrol)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 1.14.14.18 (Hmox1 protein, mouse)
SB  - IM
MH  - Amides/*pharmacology
MH  - Animals
MH  - Ethanolamines/*pharmacology
MH  - Heme Oxygenase-1
MH  - Male
MH  - Membrane Proteins
MH  - Mice
MH  - NF-E2-Related Factor 2
MH  - NF-kappa B
MH  - Palmitic Acids/*pharmacology
MH  - Rutin/*pharmacology
MH  - *Vascular System Injuries
OTO - NOTNLM
OT  - NF-kB
OT  - Nrf2
OT  - Vascular injury
OT  - inflammation
OT  - oxidative stress
OT  - rutin.
EDAT- 2021/03/31 06:00
MHDA- 2021/09/28 06:00
CRDT- 2021/03/30 05:50
PHST- 2020/10/08 00:00 [received]
PHST- 2021/01/07 00:00 [revised]
PHST- 2021/02/06 00:00 [accepted]
PHST- 2021/03/31 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2021/03/30 05:50 [entrez]
AID - CMC-EPUB-115082 [pii]
AID - 10.2174/0929867328666210329120213 [doi]
PST - ppublish
SO  - Curr Med Chem. 2021;28(30):6287-6302. doi: 10.2174/0929867328666210329120213.