PMID- 33781199
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210402
IS  - 1542-6416 (Print)
IS  - 1559-0275 (Electronic)
IS  - 1542-6416 (Linking)
VI  - 18
IP  - 1
DP  - 2021 Mar 30
TI  - The associations between red cell distribution width and plasma proteins in a 
      general population.
PG  - 12
LID - 10.1186/s12014-021-09319-9 [doi]
LID - 12
AB  - BACKGROUND: High red cell distribution width (RDW) has been increasingly 
      recognized as a risk factor for cardiovascular diseases (CVDs), but the 
      underlying mechanisms remain unknown. Our aim was to explore the associations 
      between RDW and plasma proteins implicated in the pathogenesis of CVD using a 
      targeted proteomics panel. METHODS: RDW and 88 plasma proteins were measured in a 
      population-based cohort study (n = 4726), Malmo Diet and Cancer-Cardiovascular 
      Cohort (MDC-CC). A random 2/3 of the cohort was used as discovery sample and 
      remaining 1/3 was used for replication. Multiple linear regression was used to 
      assess the associations between RDW and plasma proteins, with adjustments for 
      age, sex, and other potential confounders. Proteins with Bonferroni-corrected 
      significant associations with RDW in the discovery sub-cohort were validated in 
      the replication cohort. RESULTS: Thirteen of 88 plasma proteins had significant 
      associations with RDW in the discovery sample, after multivariate adjustments. 
      Eleven of them were also significant in the replication sample, including 
      SIR2-like protein 2 (SIRT2), stem cell factor (SCF, inversely), melusin 
      (ITGB1BP2), growth differentiation factor-15 (GDF-15), matrix metalloproteinase-7 
      (MMP-7), hepatocyte growth factor (HGF), chitinase-3-like protein 1 (CHI3L1), 
      interleukin-8 (IL-8), CD40 ligand (CD40-L), urokinase plasminogen activator 
      surface receptor (U-PAR) and matrix metalloproteinase-3 (MMP-3). CONCLUSIONS: 
      Several proteins from this targeted proteomics panel were associated with RDW in 
      this cohort. These proteins could potentially be linked to the increased 
      cardiovascular risk in individuals with high RDW.
FAU - Pan, Jingxue
AU  - Pan J
AUID- ORCID: 0000-0002-2231-2668
AD  - Department of Clinical Sciences, Lund University, CRC Hus 60 plan 13, Jan 
      Waldenstroms gata 35, 20502, Malmo, Sweden. jingxue.pan@med.lu.se.
FAU - Borne, Yan
AU  - Borne Y
AD  - Department of Clinical Sciences, Lund University, CRC Hus 60 plan 13, Jan 
      Waldenstroms gata 35, 20502, Malmo, Sweden.
FAU - Orho-Melander, Marju
AU  - Orho-Melander M
AD  - Department of Clinical Sciences, Lund University, CRC Hus 60 plan 13, Jan 
      Waldenstroms gata 35, 20502, Malmo, Sweden.
FAU - Nilsson, Jan
AU  - Nilsson J
AD  - Department of Clinical Sciences, Lund University, CRC Hus 60 plan 13, Jan 
      Waldenstroms gata 35, 20502, Malmo, Sweden.
FAU - Melander, Olle
AU  - Melander O
AD  - Department of Clinical Sciences, Lund University, CRC Hus 60 plan 13, Jan 
      Waldenstroms gata 35, 20502, Malmo, Sweden.
FAU - Engstrom, Gunnar
AU  - Engstrom G
AD  - Department of Clinical Sciences, Lund University, CRC Hus 60 plan 13, Jan 
      Waldenstroms gata 35, 20502, Malmo, Sweden.
LA  - eng
GR  - 2016-0315/Hjart-Lungfonden (SE)/
GR  - 2017-0626/Hjart-Lungfonden/
GR  - 201806230280/China Scholarship Council/
PT  - Journal Article
DEP - 20210330
PL  - England
TA  - Clin Proteomics
JT  - Clinical proteomics
JID - 101184586
PMC - PMC8008679
OTO - NOTNLM
OT  - Cardiovascular panel
OT  - Plasma proteomics
OT  - Population-based
OT  - Red cell distribution width
COIS- The authors declare that they have no competing conflicts of interests.
EDAT- 2021/03/31 06:00
MHDA- 2021/03/31 06:01
PMCR- 2021/03/30
CRDT- 2021/03/30 05:51
PHST- 2020/02/21 00:00 [received]
PHST- 2021/03/12 00:00 [accepted]
PHST- 2021/03/30 05:51 [entrez]
PHST- 2021/03/31 06:00 [pubmed]
PHST- 2021/03/31 06:01 [medline]
PHST- 2021/03/30 00:00 [pmc-release]
AID - 10.1186/s12014-021-09319-9 [pii]
AID - 9319 [pii]
AID - 10.1186/s12014-021-09319-9 [doi]
PST - epublish
SO  - Clin Proteomics. 2021 Mar 30;18(1):12. doi: 10.1186/s12014-021-09319-9.