PMID- 33781967
OWN - NLM
STAT- MEDLINE
DCOM- 20220112
LR  - 20220112
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 92
DP  - 2021 Aug
TI  - Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are 
      associated with malaria susceptibility in the Beninese Toffin children.
PG  - 104828
LID - S1567-1348(21)00125-8 [pii]
LID - 10.1016/j.meegid.2021.104828 [doi]
AB  - BACKGROUND: Little attention has been devoted to the role of the immunoregulatory 
      HLA-E/-F/-G genes in malaria. We evaluated the entire HLA-E/-F/-G variability in 
      Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. 
      METHODS: 154 unrelated children were followed-up for six months and evaluated for 
      the presence and number of malaria episodes. HLA-E/-F/-G genes were genotyped 
      using massively parallel sequencing. Anti P.f. antibodies were evaluated using 
      ELISA. RESULTS: Children carrying the G allele at HLA-F (-1499,rs183540921) 
      showed increased P.f. asymptomatic/symptomatic ratio, suggesting that these 
      children experienced more asymptomatic P.f. episodes than symptomatic one. 
      Children carrying HLA-G-UTR-03 haplotype exhibited increased risk for symptomatic 
      P.f. episodes and showed lower IgG2 response against P.f. GLURP-R2 when compared 
      to the non-carriers. No associations were observed for the HLA-E gene. 
      CONCLUSION: HLA-F associations may be related to the differential expression 
      profiles of the encoded immunomodulatory molecules, and the regulatory sites at 
      the HLA-G 3'UTR may be associated to posttranscriptional regulation of HLA-G and 
      to host humoral response against P.f.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Sonon, Paulin
AU  - Sonon P
AD  - Post-graduate Program in Basic and Applied Immunology, Ribeirao Preto Medical 
      School, University of Sao Paulo, Avenida Bandeirantes, 3900, Monte Alegre, 
      14049-900 Ribeirao Preto, SP, Brazil; Immunogenetic Laboratory, Immunology 
      Department, Aggeu Magalhaes Institute, Oswaldo Cruz Foundation, Av. Moraes rego, 
      s/n, Campus da UFPE, Cidade Universitaria, 50670420 Recife, PE, Brazil.
FAU - Tokplonou, Leonidas
AU  - Tokplonou L
AD  - Centre d'Etude et de Recherche sur le Paludisme Associe a la Grossesse et a 
      l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, Benin; Universite 
      de Paris, UMR 261 MERIT, IRD, F-75006 Paris, France; Departement de Zoologie, 
      Faculte des Sciences et Techniques, Universite d'Abomey-Calavi, Cotonou, Benin.
FAU - Sadissou, Ibrahim
AU  - Sadissou I
AD  - Post-graduate Program in Basic and Applied Immunology, Ribeirao Preto Medical 
      School, University of Sao Paulo, Avenida Bandeirantes, 3900, Monte Alegre, 
      14049-900 Ribeirao Preto, SP, Brazil; Intertryp, IRD, Cirad, University of 
      Montpellier, Avenue Agropolis, 34398 Montpellier Cedex 5, France.
FAU - M'po, Kuumaate K G
AU  - M'po KKG
AD  - Centre d'Etude et de Recherche sur le Paludisme Associe a la Grossesse et a 
      l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, Benin; 
      Departement de Zoologie, Faculte des Sciences et Techniques, Universite 
      d'Abomey-Calavi, Cotonou, Benin.
FAU - Glitho, Sonya S C
AU  - Glitho SSC
AD  - Centre d'Etude et de Recherche sur le Paludisme Associe a la Grossesse et a 
      l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, Benin; 
      Departement de Zoologie, Faculte des Sciences et Techniques, Universite 
      d'Abomey-Calavi, Cotonou, Benin.
FAU - Agniwo, Privat
AU  - Agniwo P
AD  - Centre d'Etude et de Recherche sur le Paludisme Associe a la Grossesse et a 
      l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, Benin; 
      Departement de Zoologie, Faculte des Sciences et Techniques, Universite 
      d'Abomey-Calavi, Cotonou, Benin.
FAU - Ibikounle, Moudachirou
AU  - Ibikounle M
AD  - Departement de Zoologie, Faculte des Sciences et Techniques, Universite 
      d'Abomey-Calavi, Cotonou, Benin.
FAU - Souza, Andreia S
AU  - Souza AS
AD  - Sao Paulo State University (UNESP), School of Medicine, Molecular Genetics and 
      Bioinformatics Laboratory, Av. Prof. Dr. Walter Mauricio Correa, s/n, 1861868, 
      Botucatu, SP, Brazil.
FAU - Massaro, Juliana Doblas
AU  - Massaro JD
AD  - Post-graduate Program in Basic and Applied Immunology, Ribeirao Preto Medical 
      School, University of Sao Paulo, Avenida Bandeirantes, 3900, Monte Alegre, 
      14049-900 Ribeirao Preto, SP, Brazil.
FAU - Gonzalez, Daniel
AU  - Gonzalez D
AD  - Universite de Paris, UMR 261 MERIT, IRD, F-75006 Paris, France.
FAU - Tchegninougbo, Theophile
AU  - Tchegninougbo T
AD  - Centre Medical Saint Joseph, So Ava, Benin.
FAU - Ayitchedji, Aurele
AU  - Ayitchedji A
AD  - Centre Medical Saint Joseph, So Ava, Benin.
FAU - Massougbodji, Achille
AU  - Massougbodji A
AD  - Centre d'Etude et de Recherche sur le Paludisme Associe a la Grossesse et a 
      l'Enfance (CERPAGE), Faculte des Sciences de la Sante, Cotonou, Benin.
FAU - Moreau, Philippe
AU  - Moreau P
AD  - CEA, DRF-Institut Francois Jacob, Service de Recherches en Hemato-Immunologie, 
      Hopital Saint-Louis, 75010 Paris, France; Universite de Paris, CEA, U976 HIPI 
      Unit (Human Immunology, Physiopathology, Immunotherapy), Institut de Recherche 
      Saint-Louis, 75010 Paris, France.
FAU - Garcia, Andre
AU  - Garcia A
AD  - Universite de Paris, UMR 261 MERIT, IRD, F-75006 Paris, France.
FAU - Milet, Jacqueline
AU  - Milet J
AD  - Universite de Paris, UMR 261 MERIT, IRD, F-75006 Paris, France.
FAU - Sabbagh, Audrey
AU  - Sabbagh A
AD  - Universite de Paris, UMR 261 MERIT, IRD, F-75006 Paris, France.
FAU - Mendes-Junior, Celso T
AU  - Mendes-Junior CT
AD  - Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao 
      Preto, Universidade de Sao Paulo, AV Bandeirantes, 3900, 14040901 Ribeirao Preto, 
      SP, Brazil.
FAU - Moutairou, Kabirou A
AU  - Moutairou KA
AD  - Laboratoire de Biologie et Physiologie Cellulaire, Universite d'Abomey-Calavi, 
      Cotonou, Benin.
FAU - Castelli, Erick C
AU  - Castelli EC
AD  - Sao Paulo State University (UNESP), School of Medicine, Molecular Genetics and 
      Bioinformatics Laboratory, Av. Prof. Dr. Walter Mauricio Correa, s/n, 1861868, 
      Botucatu, SP, Brazil; Sao Paulo State University (UNESP), Department of 
      Pathology, School of Medicine, Botucatu, State of Sao Paulo, SP, Brazil.
FAU - Courtin, David
AU  - Courtin D
AD  - Universite de Paris, UMR 261 MERIT, IRD, F-75006 Paris, France.
FAU - Donadi, Eduardo A
AU  - Donadi EA
AD  - Post-graduate Program in Basic and Applied Immunology, Ribeirao Preto Medical 
      School, University of Sao Paulo, Avenida Bandeirantes, 3900, Monte Alegre, 
      14049-900 Ribeirao Preto, SP, Brazil. Electronic address: eadonadi@fmrp.usp.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210327
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (3' Untranslated Regions)
RN  - 0 (HLA-F antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - 3' Untranslated Regions/genetics
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-G Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Immunoglobulin G/genetics
MH  - Malaria, Falciparum/*genetics
MH  - Male
MH  - Plasmodium falciparum/pathogenicity
MH  - Polymorphism, Single Nucleotide/*genetics
OTO - NOTNLM
OT  - Antibody
OT  - HLA-Ib
OT  - Haplotype
OT  - Plasmodium falciparum
OT  - SNV
EDAT- 2021/03/31 06:00
MHDA- 2022/01/13 06:00
CRDT- 2021/03/30 06:26
PHST- 2020/11/28 00:00 [received]
PHST- 2021/02/05 00:00 [revised]
PHST- 2021/03/24 00:00 [accepted]
PHST- 2021/03/31 06:00 [pubmed]
PHST- 2022/01/13 06:00 [medline]
PHST- 2021/03/30 06:26 [entrez]
AID - S1567-1348(21)00125-8 [pii]
AID - 10.1016/j.meegid.2021.104828 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2021 Aug;92:104828. doi: 10.1016/j.meegid.2021.104828. Epub 
      2021 Mar 27.