PMID- 33782709
OWN - NLM
STAT- MEDLINE
DCOM- 20210517
LR  - 20210519
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Print)
IS  - 0021-8812 (Linking)
VI  - 99
IP  - 5
DP  - 2021 May 1
TI  - Genomics of response to porcine reproductive and respiratory syndrome virus in 
      purebred and crossbred sows: antibody response and performance following natural 
      infection vs. vaccination.
LID - 10.1093/jas/skab097 [doi]
LID - skab097
AB  - Antibody response, measured as sample-to-positive (S/P) ratio, to porcine 
      reproductive and respiratory syndrome virus (PRRSV) following a PRRSV-outbreak 
      (S/POutbreak) in a purebred nucleus and following a PRRSV-vaccination (S/PVx) in 
      commercial crossbred herds have been proposed as genetic indicator traits for 
      improved reproductive performance in PRRSV-infected purebred and PRRSV-vaccinated 
      crossbred sows, respectively. In this study, we investigated the genetic 
      relationships of S/POutbreak and S/PVx with performance at the commercial 
      (vaccinated crossbred sows) and nucleus level (non-infected and PRRSV-infected 
      purebred sows), respectively, and tested the effect of previously identified SNP 
      for these indicator traits. Antibody response was measured on 541 Landrace sows 
      ~54 d after the start of a PRRSV outbreak, and on 906 F1 (Landrace x Large White) 
      gilts ~50 d after vaccination with a commercial PRRSV vaccine. Reproductive 
      performance was recorded for 711 and 428 Landrace sows before and during the 
      PRRSV outbreak, respectively, and for 811 vaccinated F1 animals. The estimate of 
      the genetic correlation (rg) of S/POutbreak with S/PVx was 0.72 +/- 0.18. The 
      estimates of rg of S/POutbreak with reproductive performance in vaccinated 
      crossbred sows were low to moderate, ranging from 0.05 +/- 0.23 to 0.30 +/- 0.20. The 
      estimate of rg of S/PVx with reproductive performance in non-infected purebred 
      sows was moderate and favorable with number born alive (0.50 +/- 0.23) but low (0 +/- 
      0.23 to -0.11 +/- 0.23) with piglet mortality traits. The estimates of rg of S/PVx 
      were moderate and negative (-0.38 +/- 0.21) with number of mummies in 
      PRRSV-infected purebred sows and low with other traits (-0.30 +/- 0.18 to 0.05 +/- 
      0.18). Several significant associations (P0 > 0.90) of previously reported SNP 
      for S/P ratio (ASGA0032063 and H3GA0020505) were identified for S/P ratio and 
      performance in non-infected purebred and PRRSV-exposed purebred and crossbred 
      sows. Genomic regions harboring the major histocompatibility complex class II 
      region significantly contributed to the genetic correlation of antibody response 
      to PRRSV with most of the traits analyzed. These results indicate that selection 
      for antibody response in purebred sows following a PRRSV outbreak in the nucleus 
      and for antibody response to PRRSV vaccination measured in commercial crossbred 
      sows are expected to increase litter size in purebred and commercial sows.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      American Society of Animal Science.
FAU - Sanglard, Leticia P
AU  - Sanglard LP
AD  - Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
FAU - Hickmann, Felipe M W
AU  - Hickmann FMW
AD  - Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
AD  - Department of Animal Science, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, Rio Grande do Sul, 91540-000, Brazil.
FAU - Huang, Yijian
AU  - Huang Y
AD  - Smithfield Premium Genetic, Rose Hill, NC 28458, USA.
FAU - Gray, Kent A
AU  - Gray KA
AD  - Smithfield Premium Genetic, Rose Hill, NC 28458, USA.
FAU - Linhares, Daniel C L
AU  - Linhares DCL
AD  - Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State 
      University, Ames, IA 50011, USA.
FAU - Dekkers, Jack C M
AU  - Dekkers JCM
AD  - Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
FAU - Niederwerder, Megan C
AU  - Niederwerder MC
AD  - Department of Diagnostic Medicine/Pathobiology, Kansas State University, 
      Manhattan, KS 66506, USA.
FAU - Fernando, Rohan L
AU  - Fernando RL
AD  - Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
FAU - Braccini Neto, Joseph
AU  - Braccini Neto J
AD  - Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
AD  - Department of Animal Science, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, Rio Grande do Sul, 91540-000, Brazil.
FAU - Serao, Nick V L
AU  - Serao NVL
AUID- ORCID: 0000-0002-6758-208X
AD  - Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibody Formation
MH  - Female
MH  - Genomics
MH  - *Porcine Reproductive and Respiratory Syndrome/genetics/prevention & control
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Pregnancy
MH  - Swine
MH  - *Swine Diseases
MH  - Vaccination/veterinary
MH  - *Viral Vaccines
PMC - PMC8118356
OTO - NOTNLM
OT  - PRRS
OT  - genetic correlation
OT  - major histocompatibility complex
OT  - reproductive performance
OT  - swine
EDAT- 2021/03/31 06:00
MHDA- 2021/05/18 06:00
PMCR- 2021/03/29
CRDT- 2021/03/30 08:05
PHST- 2020/12/01 00:00 [received]
PHST- 2021/03/23 00:00 [accepted]
PHST- 2021/03/31 06:00 [pubmed]
PHST- 2021/05/18 06:00 [medline]
PHST- 2021/03/30 08:05 [entrez]
PHST- 2021/03/29 00:00 [pmc-release]
AID - 6199947 [pii]
AID - skab097 [pii]
AID - 10.1093/jas/skab097 [doi]
PST - ppublish
SO  - J Anim Sci. 2021 May 1;99(5):skab097. doi: 10.1093/jas/skab097.