PMID- 33784027
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20210630
IS  - 2162-3279 (Electronic)
VI  - 11
IP  - 5
DP  - 2021 May
TI  - Optical coherence tomography angiography helps distinguish multiple sclerosis 
      from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder.
PG  - e02125
LID - 10.1002/brb3.2125 [doi]
LID - e02125
AB  - INTRODUCTION: The aim was to characterize the optical coherence tomography (OCT) 
      angiography measures in patients with multiple sclerosis (MS) and neuromyelitis 
      optica spectrum disorder (NMOSD) and to evaluate their disease discrimination 
      capacity. METHODS: Patients with MS (n = 83) and AQP4-IgG-seropositive NMOSD 
      (n = 91) with or without a history of optic neuritis, together with healthy 
      controls (n = 34), were imaged. The main outcome measures were peripapillary 
      retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell-inner 
      plexiform layer (GC-IPL) thickness, macular vessel density (VD), and perfusion 
      density (PD) in the superficial capillary plexus. Diagnostic accuracy was 
      assessed using the area under the receiver operating characteristics curve. 
      RESULTS: Compared with patients with MS, those with NMOSD had a significantly 
      smaller average thickness of the pRNFL and GC-IPL (80.0 [59.0; 95.8] mum versus 
      92.0 [80.2; 101] mum, p < .001; 68.0 [56.0; 81.0] mum, versus 74.5 [64.2; 81.0] mum, 
      p < .001) and significantly smaller whole VD and PD areas (15.6 [12.6; 17.0] 
      mm(-1) versus 16.7 [14.8; 17.7] mm(-1) , p < .001; 0.38 [0.31; 0.42] mm(-1) 
      versus 0.40 [0.37; 0.43] mm(-1) , p < .01). The combination of structural 
      parameters (average thickness of the pRNFL and GC-IPL) with microvascular 
      parameters (temporal-inner quadrant of VD, temporal-inner, nasal-inferior, and 
      nasal-outer quadrant of PD) was revealed to have a good diagnostic capability for 
      discriminating between NMOSD and MS. CONCLUSIONS: OCT angiography reveals 
      different structural and microvascular retinal changes in MS and 
      AQP4-IgG-seropositive NMOSD. These combined structural and microvascular 
      parameters might be promising biomarkers for disease diagnosis.
CI  - (c) 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Liu, Chunxin
AU  - Liu C
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Xiao, Hui
AU  - Xiao H
AD  - Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
FAU - Zhang, Xiayin
AU  - Zhang X
AD  - Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
FAU - Zhao, Yipeng
AU  - Zhao Y
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Li, Rui
AU  - Li R
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Zhong, Xiaonan
AU  - Zhong X
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Wang, Yuge
AU  - Wang Y
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Shu, Yaqing
AU  - Shu Y
AUID- ORCID: 0000-0003-1017-2554
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Chang, Yanyu
AU  - Chang Y
AUID- ORCID: 0000-0002-3226-1008
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Wang, Jingqi
AU  - Wang J
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Li, Caixia
AU  - Li C
AD  - School of Mathematics, Sun Yat-sen University, Guangzhou, China.
FAU - Lin, Haotian
AU  - Lin H
AD  - Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
FAU - Qiu, Wei
AU  - Qiu W
AUID- ORCID: 0000-0002-0880-958X
AD  - Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210330
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Angiography
MH  - Humans
MH  - Immunoglobulin G
MH  - *Multiple Sclerosis/diagnostic imaging
MH  - *Neuromyelitis Optica/diagnostic imaging
MH  - Tomography, Optical Coherence
PMC - PMC8119797
OTO - NOTNLM
OT  - multiple sclerosis
OT  - neuromyelitis optica spectrum disorder
OT  - optical coherence tomography angiography
COIS- The authors have no proprietary or commercial interest in any materials discussed 
      in this article.
EDAT- 2021/03/31 06:00
MHDA- 2021/07/01 06:00
PMCR- 2021/03/30
CRDT- 2021/03/30 12:50
PHST- 2021/02/24 00:00 [revised]
PHST- 2020/11/26 00:00 [received]
PHST- 2021/03/14 00:00 [accepted]
PHST- 2021/03/31 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2021/03/30 12:50 [entrez]
PHST- 2021/03/30 00:00 [pmc-release]
AID - BRB32125 [pii]
AID - 10.1002/brb3.2125 [doi]
PST - ppublish
SO  - Brain Behav. 2021 May;11(5):e02125. doi: 10.1002/brb3.2125. Epub 2021 Mar 30.