PMID- 33784432 OWN - NLM STAT- MEDLINE DCOM- 20210701 LR - 20210701 IS - 1097-0347 (Electronic) IS - 1043-3074 (Linking) VI - 43 IP - 7 DP - 2021 Jul TI - A dynamic prognostic nomogram to predict the benefit from surgical treatment modality for patients with laryngeal squamous cell carcinoma. PG - 2148-2158 LID - 10.1002/hed.26683 [doi] AB - BACKGROUND: Although nonsurgical treatment strategy is increasingly adopted in patients with locoregionally advanced laryngeal squamous cell carcinoma (LSCC), survival disparities were reported between surgical treatment modality and organ preservation protocols, highlighting the great importance for accurate patients' selection. METHOD: This secondary analysis used data from the Surveillance, Epidemiology, and End Results database between 2010 and 2015 with follow-up data up to 2018. We developed and validated a dynamic prognostic nomogram for overall survival (OS) in 4237 patients with LSCC and subgroup of 2087 patients with locoregionally advanced laryngeal squamous cell carcinoma (LALSCC). Based on the total risk score derived from the dynamic nomogram, two well-matched risk groups (i.e., low- and high-risk) were created via X-tile software and 1-to-1 propensity score matching (PSM); surgical treatment modality was compared with nonsurgical one in each risk group. RESULTS: A more accurate and convenient dynamic prognostic nomogram based on age, marital status, T category, N category, M category, tumor size, and tumor differentiation was developed and validated, of which the predictive performance was superior to that of TNM staging system. For high-risk LALSCC selected by the dynamic nomogram, after 1-to-1 PSM, significantly improved OS was observed in patients with receiving surgical treatment compared to those receipt of nonsurgical management (restricted mean survival time at 36-month: 26.6 vs 22.7, p < 0.001; restricted mean survival time at 60-month: 36.7 vs 31.0, p = 0.003). CONCLUSION: We establish and validate a more accurate and convenient dynamic prognostic nomogram for patients with LSCC, which may predict the benefit from surgical treatment modality for patients with high-risk LALSCC. CI - (c) 2021 Wiley Periodicals LLC. FAU - Chen, Lin AU - Chen L AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Lin, Gongbiao AU - Lin G AD - Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. FAU - Qian, Jiawen AU - Qian J AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Chen, Zhihong AU - Chen Z AD - Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. FAU - Wu, Xiaobo AU - Wu X AD - Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. FAU - Lin, Jing AU - Lin J AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Chen, Ying AU - Chen Y AD - Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. FAU - Chen, Qing AU - Chen Q AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Zhuang, Zhaocheng AU - Zhuang Z AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Hong, Yihong AU - Hong Y AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Wang, Jing AU - Wang J AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Liu, Fengqiong AU - Liu F AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Wang, Jing AU - Wang J AD - Laboratory Center, The Major Subject of Environment and Health of Fujian Key Universities, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. FAU - He, Baochang AU - He B AUID- ORCID: 0000-0002-5357-2171 AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. FAU - Chen, Fa AU - Chen F AUID- ORCID: 0000-0002-5792-9211 AD - Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. AD - Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210330 PL - United States TA - Head Neck JT - Head & neck JID - 8902541 SB - IM MH - *Head and Neck Neoplasms MH - Humans MH - *Laryngeal Neoplasms/surgery MH - Nomograms MH - Prognosis MH - Squamous Cell Carcinoma of Head and Neck OTO - NOTNLM OT - dynamic prognostic nomogram OT - laryngeal squamous cell carcinoma OT - overall survival OT - surgical treatment modality EDAT- 2021/03/31 06:00 MHDA- 2021/07/02 06:00 CRDT- 2021/03/30 17:27 PHST- 2020/12/28 00:00 [revised] PHST- 2020/09/05 00:00 [received] PHST- 2021/03/12 00:00 [accepted] PHST- 2021/03/31 06:00 [pubmed] PHST- 2021/07/02 06:00 [medline] PHST- 2021/03/30 17:27 [entrez] AID - 10.1002/hed.26683 [doi] PST - ppublish SO - Head Neck. 2021 Jul;43(7):2148-2158. doi: 10.1002/hed.26683. Epub 2021 Mar 30.