PMID- 3378510
OWN - NLM
STAT- MEDLINE
DCOM- 19880718
LR  - 20190116
IS  - 0148-0545 (Print)
IS  - 0148-0545 (Linking)
VI  - 11
IP  - 1
DP  - 1988
TI  - Dietary iron and 2,3,7,8-tetrachlorodibenzo-p-dioxin induced alterations in 
      hepatic lipid peroxidation, glutathione content and body weight.
PG  - 55-70
AB  - The effects of various levels of dietary iron on hepatic lipid peroxidation 
      (malondialdehyde [MDA] content), reduced glutathione (GSH) and GSH peroxidase 
      (GSH-PX) activity as well as liver and body weights of female rats following TCDD 
      administration were examined. Rats were fed diets containing deficient (6 ppm), 
      normal (35 ppm) and supplemented (120 ppm) iron for 17, 24 and 31 days. 
      2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, 40 micrograms/kg/day P.O.) in corn oil 
      or the vehicle was given on days 9, 8 and 7 prior to sacrifice. TCDD treatment 
      produced a 3-fold increase in hepatic MDA content in animals on normal iron diet. 
      TCDD administration failed to increased MDA content in iron deficient animals. In 
      the iron supplemented groups, TCDD resulted in 2.5 fold increases in lipid 
      peroxidation. Dietary iron had no effect on hepatic GSH-PX activity. Animals on 
      the iron deficient diet had 12-21% decreases in hepatic GSH content. TCDD 
      administration resulted in 15-22% decreases in GSH content in animals on the 
      control and iron supplemented diets. TCDD treatment resulted in significant 
      decreases in body weights of animals on all 3 diets. TCDD induced lipid 
      peroxidation appears to be iron dependent. However, the loss in body weight due 
      to TCDD toxicity may not be dependent on lipid peroxidation.
FAU - al-Turk, W A
AU  - al-Turk WA
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, University of 
      Nebraska Medical Center, Omaha 68105-1065.
FAU - Shara, M A
AU  - Shara MA
FAU - Mohammadpour, H
AU  - Mohammadpour H
FAU - Stohs, S J
AU  - Stohs SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Drug Chem Toxicol
JT  - Drug and chemical toxicology
JID - 7801723
RN  - 0 (Dioxins)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Diet
MH  - Dioxins/*toxicity
MH  - Female
MH  - Glutathione/*metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Iron/*administration & dosage
MH  - Lipid Peroxides/*biosynthesis
MH  - Liver/*drug effects/enzymology/metabolism
MH  - Malondialdehyde/metabolism
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.3109/01480548809038656 [doi]
PST - ppublish
SO  - Drug Chem Toxicol. 1988;11(1):55-70. doi: 10.3109/01480548809038656.