PMID- 33785460
OWN - NLM
STAT- MEDLINE
DCOM- 20210910
LR  - 20210910
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 127
IP  - 1
DP  - 2021 Jul
TI  - Serum-free immunoglobulin E: A useful biomarker of atopy and type 2 asthma in 
      adults with asthma.
PG  - 109-115.e1
LID - S1081-1206(21)00255-6 [pii]
LID - 10.1016/j.anai.2021.03.023 [doi]
AB  - BACKGROUND: It has been known that a high serum total immunoglobulin E (IgE) 
      level is a predisposing factor of allergic asthma; however, there are 
      considerable limitations to apply it in clinical practice. OBJECTIVE: To 
      determine the clinical significance of the serum-free IgE level in patients with 
      adult asthma. METHODS: We measured free IgE levels using our homemade 
      enzyme-linked immunosorbent assay by applying a novel IgE TRAP protein (GI 
      innovation, Seoul, Republic of Korea) in sera of adults with asthma (n = 116) 
      compared with healthy controls (n = 32); enzyme-linked immunosorbent assay 
      inhibition test was performed to validate its binding specificity. Associations 
      between asthma-related clinical and laboratory parameters were analyzed. The 
      diagnostic value and cutoff point for detecting atopy and type 2 asthma were 
      determined using receiver operating characteristic curve analysis. RESULTS: The 
      serum-free IgE levels were significantly higher in adults with asthma than in 
      healthy controls and were significantly associated with atopic status and type 2 
      asthma (all P < .001). In the receiver operating characteristic analysis, 
      serum-free IgE had a significantly greater area under the curve (AUC) than serum 
      total IgE for assessing asthma, especially type 2 asthma (AUC, 0.810 vs 0.743; 
      P = .006 and AUC, 0.729 vs 0.572; P < .001). The optimal cutoff points for 
      predicting atopy and type 2 asthma were 82.8 and 120.8 ng/mL, respectively. 
      CONCLUSION: It is suggested that a higher serum-free IgE level may be a useful 
      biomarker of atopy and type 2 asthma in adults with asthma.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Woo, Seong-Dae
AU  - Woo SD
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Republic of Korea; Division of Pulmonology, Department of 
      Internal Medicine, Chungnam National University School of Medicine, Daejeon, 
      Republic of Korea.
FAU - Yang, Eun-Mi
AU  - Yang EM
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Republic of Korea.
FAU - Jang, Jaehyuk
AU  - Jang J
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Republic of Korea.
FAU - Lee, Youngsoo
AU  - Lee Y
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Republic of Korea.
FAU - Shin, Yoo Seob
AU  - Shin YS
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Republic of Korea.
FAU - Ye, Young-Min
AU  - Ye YM
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Republic of Korea.
FAU - Nam, Su Youn
AU  - Nam SY
AD  - Research Institute, GI Innovation Inc., Seoul, Republic of Korea.
FAU - Lee, Kyung Wha
AU  - Lee KW
AD  - Research Institute, GI Innovation Inc., Seoul, Republic of Korea.
FAU - Jang, Myoung Ho
AU  - Jang MH
AD  - Research Institute, GI Innovation Inc., Seoul, Republic of Korea.
FAU - Park, Hae-Sim
AU  - Park HS
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Republic of Korea. Electronic address: hspark@ajou.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210327
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allergens/immunology
MH  - Area Under Curve
MH  - Asthma/blood/*diagnosis
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/*diagnosis
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Republic of Korea
EDAT- 2021/04/01 06:00
MHDA- 2021/09/11 06:00
CRDT- 2021/03/31 05:56
PHST- 2021/01/12 00:00 [received]
PHST- 2021/03/17 00:00 [revised]
PHST- 2021/03/23 00:00 [accepted]
PHST- 2021/04/01 06:00 [pubmed]
PHST- 2021/09/11 06:00 [medline]
PHST- 2021/03/31 05:56 [entrez]
AID - S1081-1206(21)00255-6 [pii]
AID - 10.1016/j.anai.2021.03.023 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2021 Jul;127(1):109-115.e1. doi: 
      10.1016/j.anai.2021.03.023. Epub 2021 Mar 27.