PMID- 33786229
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210402
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 2
DP  - 2021 Feb 23
TI  - Correlation of Vitamin D Deficiency With Severity of Chronic Heart Failure as 
      Assessed by Functional Class and N-Terminal Pro-Brain Natriuretic Peptide Levels.
PG  - e13522
LID - 10.7759/cureus.13522 [doi]
LID - e13522
AB  - Introduction Chronic heart failure (CHF) is a major cause of mortality and 
      morbidity in spite of tremendous advances in medical therapies. Vitamin D 
      deficiency has been increasingly recognised in heart failure and its therapeutic 
      as well as prognostic implications are debated. This study was carried out to 
      examine the relationship of Vitamin D levels with severity of heart failure as 
      assessed by NYHA functional class and serum N-terminal pro-brain natriuretic 
      peptide (NT-pro-BNP) levels in vitamin D deficient patients with CHF. Methodology 
      and results In this cross-sectional analysis, 119 patients of symptomatic CHF 
      presenting to the outpatient/inpatient department of cardiology in a tertiary 
      care institute in North India were screened. Patients were categorised according 
      to their functional class as New York Heart Association (NYHA) class II, III, IV 
      and their serum levels of vitamin D and NT-pro-BNP were measured. Out of 119 
      patients, 107 (90%) were found to have low vitamin D levels which were classified 
      as insufficient (20-30 ng/ml) (n=25, 23%) or deficient (<20 ng/ml) (n=82,77%). 
      The mean NT-pro-BNP levels increased significantly across functional class as 
      3783+/-6132 pg/ml, 7866+/-4383 pg/ml, 21115+/-11905 pg/ml in NYHA class II, III and IV 
      respectively (p=0.000). The respective mean serum Vitamin D3 levels of 
      11.6+/-5.8ng/ml, 12.2+/-7.9 ng/ml, 14.4+/-8.9 ng/ml were not significantly different 
      between classes (p=0.234). We found no correlation between serum NT-pro-BNP and 
      serum vitamin D levels in the study cohort across various NYHA classes. In 
      multivariate regression model, after adjusting for various co-variates, vitamin D 
      levels were not significantly associated with NT-pro-BNP or functional class in 
      patients with CHF. Conclusion Patients with CHF have a high prevalence (90%) of 
      vitamin D deficiency. Although NT-pro-BNP levels increase significantly, vitamin 
      D levels do not vary significantly with worsening NYHA classes. Further, no 
      consistent significant correlation of vitamin D deficiency with NT-pro-BNP across 
      different NYHA classes was observed. Thus, low levels of vitamin D didn't predict 
      the severity and prognosis of patients with heart failure. .
CI  - Copyright (c) 2021, Otaal et al.
FAU - Otaal, Parminder S
AU  - Otaal PS
AD  - Department of Cardiology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, IND.
FAU - Pachipala, Sudheer
AU  - Pachipala S
AD  - Department of Medicine, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, IND.
FAU - Uppal, Lipi
AU  - Uppal L
AD  - Department of Cardiology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, IND.
FAU - Bootla, Dinakar
AU  - Bootla D
AD  - Department of Cardiology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, IND.
LA  - eng
PT  - Journal Article
DEP - 20210223
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC7996472
OTO - NOTNLM
OT  - heart failure
OT  - nt-pro bnp
OT  - severity
OT  - vitamin-d deficiency
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/04/01 06:00
MHDA- 2021/04/01 06:01
PMCR- 2021/02/23
CRDT- 2021/03/31 06:41
PHST- 2021/03/31 06:41 [entrez]
PHST- 2021/04/01 06:00 [pubmed]
PHST- 2021/04/01 06:01 [medline]
PHST- 2021/02/23 00:00 [pmc-release]
AID - 10.7759/cureus.13522 [doi]
PST - epublish
SO  - Cureus. 2021 Feb 23;13(2):e13522. doi: 10.7759/cureus.13522.