PMID- 33786891
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20210702
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 34
IP  - 6
DP  - 2021 Jun
TI  - Stratifying the humoral risk of candidates to a solid organ transplantation: a 
      proposal of the ENGAGE working group.
PG  - 1005-1018
LID - 10.1111/tri.13874 [doi]
AB  - Detection of circulating antibodies directed against human leukocyte antigen 
      (HLA) molecules, which corresponds to the current definition of 'sensitized 
      patient', has been shown to have a severe impact on both access to 
      transplantation and, if the anti-HLA antibodies are specific to the selected 
      donor, survival of the graft. However, not all donor-specific antibodies (DSA) 
      are equally harmful to the graft and progress in the understanding of humoral 
      memory has led to the conclusion that absence of DSA at transplantation does not 
      rule out the possibility that the patient has a preformed cellular humoral memory 
      against the graft (thereby defining a category of DSA-negative sensitized 
      recipients). Technological progress has led to the generation of new assays that 
      offer unprecedented precision in exploring the different layers (serological and 
      cellular) of alloimmune humoral memory. Based on this recent knowledge, the 
      EuropeaN Guidelines for the mAnagement of Graft rEcipients (ENGAGE) working group 
      to propose an updated definition of sensitization in candidates for solid organ 
      transplantation - one that moves away from the current binary division towards a 
      definition based on homogenous strata with similar humoral risk.
CI  - (c) 2021 Steunstichting ESOT. Published by John Wiley & Sons Ltd.
FAU - Bestard, Oriol
AU  - Bestard O
AUID- ORCID: 0000-0001-9468-7920
AD  - Kidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, 
      Barcelona, Spain.
AD  - Bellvitge Research Institute (IDIBELL), Barcelona, Spain.
FAU - Couzi, Lionel
AU  - Couzi L
AUID- ORCID: 0000-0002-9213-6196
AD  - Nephrology-Transplantation-Dialysis, CHU Bordeaux, Bordeaux, France.
AD  - CNRS-UMR 5164 Immuno ConcEpT, Bordeaux University, Bordeaux, France.
FAU - Crespo, Marta
AU  - Crespo M
AUID- ORCID: 0000-0001-6992-6379
AD  - Department of Nephrology, Hospital del Mar, Barcelona, Spain.
AD  - Nephropathies Research Group, Hospital del Mar Medical Research Institute (IMIM), 
      Barcelona, Spain.
FAU - Kessaris, Nicos
AU  - Kessaris N
AUID- ORCID: 0000-0002-4067-7003
AD  - Department of Nephrology and Transplantation, Guy's Hospital, London, UK.
AD  - King's College London, London, UK.
FAU - Thaunat, Olivier
AU  - Thaunat O
AUID- ORCID: 0000-0002-3648-8963
AD  - Service de Transplantation, Nephrologie et Immunologie Clinique, Hopital Edouard 
      Herriot, Lyon, France.
AD  - Universite Claude-Bernard Lyon I, Lyon, France.
AD  - Institut National de la Sante et de la Recherche Medicale U1111, Lyon, France.
LA  - eng
GR  - Chiesi/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210422
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Graft Rejection
MH  - Graft Survival
MH  - HLA Antigens
MH  - Humans
MH  - Isoantibodies
MH  - *Kidney Transplantation
MH  - *Organ Transplantation
OTO - NOTNLM
OT  - antibody-mediated rejection
OT  - humoral alloimmune response
OT  - presensitization
EDAT- 2021/04/01 06:00
MHDA- 2021/07/03 06:00
CRDT- 2021/03/31 07:00
PHST- 2021/03/04 00:00 [received]
PHST- 2021/03/26 00:00 [accepted]
PHST- 2021/04/01 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2021/03/31 07:00 [entrez]
AID - 10.1111/tri.13874 [doi]
PST - ppublish
SO  - Transpl Int. 2021 Jun;34(6):1005-1018. doi: 10.1111/tri.13874. Epub 2021 Apr 22.