PMID- 33787074
OWN - NLM
STAT- MEDLINE
DCOM- 20220930
LR  - 20221107
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 74
IP  - 10
DP  - 2022 Oct
TI  - Parent-Reported Medication Side Effects and Their Impact on Health-Related 
      Quality of Life in Children With Juvenile Idiopathic Arthritis.
PG  - 1567-1574
LID - 10.1002/acr.24610 [doi]
AB  - OBJECTIVE: To describe the frequency and severity of parent-reported medication 
      side effects (SEs) in children with juvenile idiopathic arthritis (JIA) relative 
      to physician-reported actionable adverse events (AEs), and to assess their impact 
      on health-related quality of life (HRQoL). METHODS: Newly diagnosed JIA patients 
      recruited between 2017 and 2019 to the Canadian Alliance of Pediatric 
      Rheumatology Investigators (CAPRI) Registry were included. Parents reported 
      presence and severity (0 = no problem, 10 = very severe) of medication SEs at 
      every clinic visit. Physicians were asked to report any actionable AE. HRQoL was 
      assessed using the Quality of My Life (QoML) questionnaire (0 = the worst, 
      10 = the best) and parent's global assessment (0 = very well, 10 = very poor). 
      Analyses included proportion of visits with SEs or actionable AEs, cumulative 
      incidence by Kaplan-Meier methods, and HRQoL impact measured with longitudinal 
      mixed-effects models. RESULTS: SEs were reported at 371 of 884 (42%) visits (95% 
      confidence interval [95% CI] 39, 45%) in 249 patients, with a median of 2 SEs per 
      visit (interquartile range [IQR] 1-3), and median severity of 3 (IQR 1.5-5). Most 
      SEs were gastrointestinal (32.5% of visits) or behavioral/psychiatric (22.4%). SE 
      frequency was lowest with nonsteroidal antiinflammatory drugs alone (34.7%) and 
      highest with prednisone and methotrexate combinations (66%). SE cumulative 
      incidence was 67% (95% CI 59, 75) within 1 year of diagnosis, and 36% (95% CI 28, 
      44) for actionable AEs. Parent global and QoML scores were worse with SEs 
      present; the impact persisted after adjusting for pain and number of active 
      joints. CONCLUSION: Parents report that two-thirds of children with JIA 
      experience SEs impacting their HRQoL within 1 year of diagnosis. SE mitigation 
      strategies are needed in managing JIA.
CI  - (c) 2021 American College of Rheumatology.
FAU - Chedeville, Gaelle
AU  - Chedeville G
AUID- ORCID: 0000-0001-9702-7776
AD  - McGill University, Montreal, Quebec, Canada.
FAU - McGuire, Katherine
AU  - McGuire K
AD  - University of Ottawa, Ottawa, Ontario, Canada.
FAU - Cabral, David A
AU  - Cabral DA
AD  - University of British Columbia, British Columbia, Canada.
FAU - Shiff, Natalie J
AU  - Shiff NJ
AUID- ORCID: 0000-0002-7410-9709
AD  - University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Rumsey, Dax G
AU  - Rumsey DG
AD  - University of Alberta, Edmonton, Alberta, Canada.
FAU - Proulx-Gauthier, Jean-Philippe
AU  - Proulx-Gauthier JP
AD  - Universite Laval, Quebec, Quebec, Canada.
FAU - Schmeling, Heinrike
AU  - Schmeling H
AUID- ORCID: 0000-0001-8142-8946
AD  - University of Calgary, Calgary, Alberta, Canada.
FAU - Berard, Roberta A
AU  - Berard RA
AUID- ORCID: 0000-0003-2780-0617
AD  - London Health Sciences Centre and Western University, London, Ontario, Canada.
FAU - Batthish, Michelle
AU  - Batthish M
AUID- ORCID: 0000-0001-6412-1029
AD  - McMaster University, Hamilton, Ontario, Canada.
FAU - Soon, Gordon
AU  - Soon G
AD  - University of Toronto, Toronto, Ontario, Canada.
FAU - Gerhold, Kerstin
AU  - Gerhold K
AD  - University of Manitoba, Winnipeg, Manitoba, Canada.
FAU - Gerschman, Tommy
AU  - Gerschman T
AD  - University of British Columbia, British Columbia, Canada.
FAU - Bruns, Alessandra
AU  - Bruns A
AD  - Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - Duffy, Ciaran M
AU  - Duffy CM
AD  - University of Ottawa, Ottawa, Ontario, Canada.
FAU - Tucker, Lori B
AU  - Tucker LB
AD  - University of British Columbia, British Columbia, Canada.
FAU - Guzman, Jaime
AU  - Guzman J
AUID- ORCID: 0000-0001-8977-2581
AD  - University of British Columbia, British Columbia, Canada.
CN  - CAPRI Registry Investigators
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220614
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
RN  - VB0R961HZT (Prednisone)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - *Arthritis, Juvenile/diagnosis/drug therapy/epidemiology
MH  - Canada/epidemiology
MH  - Child
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - Methotrexate/adverse effects
MH  - Parents
MH  - Prednisone/therapeutic use
MH  - Quality of Life/psychology
EDAT- 2021/04/01 06:00
MHDA- 2022/10/01 06:00
CRDT- 2021/03/31 12:30
PHST- 2021/02/16 00:00 [revised]
PHST- 2020/11/15 00:00 [received]
PHST- 2021/03/25 00:00 [accepted]
PHST- 2021/04/01 06:00 [pubmed]
PHST- 2022/10/01 06:00 [medline]
PHST- 2021/03/31 12:30 [entrez]
AID - 10.1002/acr.24610 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2022 Oct;74(10):1567-1574. doi: 10.1002/acr.24610. 
      Epub 2022 Jun 14.