PMID- 33788431
OWN - NLM
STAT- MEDLINE
DCOM- 20210402
LR  - 20210402
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 46
IP  - 2
DP  - 2021 Feb 25
TI  - [Effect of intranasal acupuncture on neurogenic inflammation in allergic rhinitis 
      rabbits].
PG  - 111-6
LID - 10.13702/j.1000-0607.200250 [doi]
AB  - OBJECTIVE: To observe the effect of intranasal acupuncture on allergic rhinitis 
      (AR), and expression of substance P (SP), vasoactive intestinal peptide (VIP) and 
      neuropeptide Y (NPY) proteins in the nasal mucosa and contents of serum 
      immunoglobulin E (IgE), interleukin 4 (IL-4) and interferon-gamma (IFN-gamma) in AR 
      rabbits, so as to explore its mechanisms underlying improvement of AR. METHODS: 
      New Zealand rabbits were randomly divided into normal control, AR model, 
      non-acupuoint acupuncture (NAA) and intranasal acupuncture (INA) groups, with 8 
      rabbits in each group. The AR model was established by intra-peritoneal injection 
      of egg protein and nasal mucosal stimulation. In the INA group, bilateral 
      "Neiyingxiang" (EX-HN9) within the nasal cavity (the anterior attachment area of 
      the inferior turbinate, about 1 cm away from the nasal limen) were acupunctured 
      by mani-pulating the filiform needles for a while with uniform reinforcing and 
      reducing methods, followed by keeping the needles for 20 min. In the NAA group, 
      shallow acupuncture was applied to the skin of the outer margin of the cheeks, 
      followed by keeping the needle for 20 min. The acupuncture treatment was 
      conducted once every other day for 7 days. The symptoms of sneezing frequency, 
      nasal secretion amount and nasal itching were scored. The expression levels of 
      SP, VIP and NPY in the nasal mucosa tissue were detected by immunohistochemistry, 
      and the serum IgE, IL-4, and IFN-gamma contents were detected by ELISA. RESULTS: 
      After modelling, the symptom score, expression of SP and VIP, and serum IgE and 
      IL-4 contents were significantly higher (P<0.01,P<0.05), NPY expression and serum 
      IFN-gamma content significantly lower (P<0.05, P<0.01) in the model group than in the 
      normal control group. Following the intervention, the symptom scores, expressions 
      of SP and VIP, and serum IgE and IL-4 contents were remarkably decreased (P<0.05, 
      P<0.01), while the NPY expression and serum IFN-gamma content were significantly 
      up-regulated (P<0.05, P<0.01) in the INA group than in the model group. The 
      effects of INA group were significantly superior to those of NAA group in 
      reducing symptom score, SP and VIP expression, and serum IgE and IL-4 contents 
      and up-regulating NPY expression and IFN-gammacontent (P<0.05, P<0.01). There were a 
      positive correlation between the expressions of SP and VIP and contents of serum 
      IgE and IL-4 (P<0.05), and a negative correlation between the expressions of SP 
      and VIP and IFN-gamma content (P<0.05). CONCLUSION: INA treatment can relieve 
      symptoms of AR in AR rabbits, which may be associated with its effects in 
      regulating the expression of SP, VIP and NPY of the nasal mucosa, and contents of 
      serum IgE, IL-4 and IFN-gamma to improve neurogenic inflammation.
FAU - Gong, Zheng
AU  - Gong Z
AD  - Dongzhimen Hospital (Tongzhou Branch), Beijing University of Chinese Medicine, 
      Beijing 101149, China.
FAU - Yan, Zhan-Feng
AU  - Yan ZF
AD  - Dongzhimen Hospital (Dongcheng District), Beijing University of Chinese Medicine, 
      Beijing 100010.
FAU - Liu, Qiao-Ping
AU  - Liu QP
AD  - Dongzhimen Hospital (Dongcheng District), Beijing University of Chinese Medicine, 
      Beijing 100010.
FAU - Liu, Li-Li
AU  - Liu LL
AD  - Dongzhimen Hospital (Dongcheng District), Beijing University of Chinese Medicine, 
      Beijing 100010.
FAU - Liu, Si-Ming
AU  - Liu SM
AD  - Dongzhimen Hospital (Dongcheng District), Beijing University of Chinese Medicine, 
      Beijing 100010.
FAU - Jiao, Lu-Lu
AU  - Jiao LL
AD  - Dongzhimen Hospital (Dongcheng District), Beijing University of Chinese Medicine, 
      Beijing 100010.
FAU - Bian, Fang-Zi
AU  - Bian FZ
AD  - Beijing University of Chinese Medicine, Beijing 100029.
FAU - Zhang, Lin-Jing
AU  - Zhang LJ
AD  - Beijing University of Chinese Medicine, Beijing 100029.
FAU - Zhang, Lin-Lin
AU  - Zhang LL
AD  - Beijing University of Chinese Medicine, Beijing 100029.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Acupuncture Therapy
MH  - Animals
MH  - Immunoglobulin E
MH  - Nasal Mucosa
MH  - Neurogenic Inflammation
MH  - Rabbits
MH  - *Rhinitis, Allergic/genetics/therapy
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Intranasal acupuncture
OT  - Neiyingxiang acupoint(EX-HN9)
OT  - Neurogenic inflammation
OT  - Neuropeptide
EDAT- 2021/04/01 06:00
MHDA- 2021/04/07 06:00
CRDT- 2021/03/31 13:44
PHST- 2021/03/31 13:44 [entrez]
PHST- 2021/04/01 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
AID - 10.13702/j.1000-0607.200250 [doi]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2021 Feb 25;46(2):111-6. doi: 10.13702/j.1000-0607.200250.