PMID- 33789701
OWN - NLM
STAT- MEDLINE
DCOM- 20210816
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 23
IP  - 1
DP  - 2021 Apr 1
TI  - Cardiovascular magnetic resonance-assessed fast global longitudinal strain 
      parameters add diagnostic and prognostic insights in right ventricular volume and 
      pressure loading disease conditions.
PG  - 38
LID - 10.1186/s12968-021-00724-5 [doi]
LID - 38
AB  - BACKGROUND: Parameters of myocardial deformation may provide improved insights 
      into right ventricular (RV) dysfunction. We quantified RV longitudinal myocardial 
      function using a fast, semi-automated method and investigated its diagnostic and 
      prognostic values in patients with repaired tetralogy of Fallot (rTOF) and 
      pulmonary arterial hypertension (PAH), who respectively exemplify patients with 
      RV volume and pressure overload conditions. METHODS: The study enrolled 150 
      patients (rTOF, n = 75; PAH, n = 75) and 75 healthy controls. RV parameters of 
      interest were fast global longitudinal strain (GLS) and strain rates during 
      systole (GLSR(s)), early diastole (GLSR(e)) and late diastole (GLSR(a)), obtained 
      by tracking the distance from the medial and lateral tricuspid valve insertions 
      to the RV epicardial apex on cine cardiovascular magnetic resonance (CMR). 
      RESULTS: The RV fast GLS exhibited good agreement with strain values obtained by 
      conventional feature tracking approach (bias - 4.9%, error limits (+/- 2.standard 
      deviation) +/- 4.3%) with fast GLS achieving greater reproducibility and requiring 
      reduced analysis time. Mean RV fast GLS was reduced in PAH and rTOF groups 
      compared to healthy controls (PAH < rTOF < healthy controls: 
      15.1 +/- 4.9 < 19.3 +/- 2.4 < 24.4 +/- 3.0%, all P < 0.001 in pairwise comparisons). In 
      rTOF patients, RV fast GLS was significantly associated with metabolic 
      equivalents, peak oxygen consumption (PVO(2)) and percentage of predicted PVO(2) 
      achieved during cardiopulmonary exercise testing. Lower RV fast GLS was 
      associated with subnormal exercise capacity in rTOF (area under the curve 
      (AUC) = 0.822, sensitivity = 72%, specificity = 91%, cut-off = 19.3%). In PAH 
      patients, reduced RV fast GLS was associated with RV decompensated hemodynamics 
      (AUC = 0.717, sensitivity = 75%, specificity = 58%, cut-off = 14.6%) and higher 
      risk of clinical worsening (AUC = 0.808, sensitivity = 79%, specificity = 70 %, 
      cut-off = 16.0%). CONCLUSIONS: Quantitative RV fast strain and strain rate 
      parameters assessed from CMR identify abnormalities of RV function in rTOF and 
      PAH and are predictive of exercise capacity, RV decompensation and clinical risks 
      in these patients. Trial registry Clinicaltrials.gov: NCT03217240.
FAU - Leng, Shuang
AU  - Leng S
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 5 
      Hospital Drive, 169609, Singapore, Singapore.
FAU - Tan, Ru-San
AU  - Tan RS
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 5 
      Hospital Drive, 169609, Singapore, Singapore.
AD  - Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
FAU - Guo, Jiajun
AU  - Guo J
AD  - Cardiology Division, Department of Medicine, West China Hospital, Sichuan 
      University, No. 37 Guoxue Alley, Wuhou District, Chengdu City, 610041, Sichuan, 
      People's Republic of China.
FAU - Chai, Ping
AU  - Chai P
AD  - Department of Cardiology, National University Heart Centre Singapore, Singapore, 
      Singapore.
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
FAU - Zhang, Gangcheng
AU  - Zhang G
AD  - Wuhan Asia Heart Hospital, Wuhan City, Hubei, People's Republic of China.
FAU - Teo, Lynette
AU  - Teo L
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
AD  - Department of Diagnostic Imaging, National University Hospital, Singapore, 
      Singapore.
FAU - Ruan, Wen
AU  - Ruan W
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 5 
      Hospital Drive, 169609, Singapore, Singapore.
FAU - Yeo, Tee Joo
AU  - Yeo TJ
AD  - Department of Cardiology, National University Heart Centre Singapore, Singapore, 
      Singapore.
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
FAU - Zhao, Xiaodan
AU  - Zhao X
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 5 
      Hospital Drive, 169609, Singapore, Singapore.
FAU - Allen, John C
AU  - Allen JC
AD  - Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
FAU - Tan, Ju Le
AU  - Tan JL
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 5 
      Hospital Drive, 169609, Singapore, Singapore.
AD  - Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
FAU - Yip, James W
AU  - Yip JW
AD  - Department of Cardiology, National University Heart Centre Singapore, Singapore, 
      Singapore.
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
FAU - Chen, Yucheng
AU  - Chen Y
AD  - Cardiology Division, Department of Medicine, West China Hospital, Sichuan 
      University, No. 37 Guoxue Alley, Wuhou District, Chengdu City, 610041, Sichuan, 
      People's Republic of China. chenyucheng2003@126.com.
FAU - Zhong, Liang
AU  - Zhong L
AD  - National Heart Research Institute Singapore, National Heart Centre Singapore, 5 
      Hospital Drive, 169609, Singapore, Singapore. zhong.liang@nhcs.com.sg.
AD  - Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. 
      zhong.liang@nhcs.com.sg.
LA  - eng
SI  - ClinicalTrials.gov/NCT03217240
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210401
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
SB  - IM
MH  - Adult
MH  - Automation
MH  - Cardiac Surgical Procedures/adverse effects
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - *Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Pulmonary Arterial Hypertension/complications/*diagnostic imaging/physiopathology
MH  - Reproducibility of Results
MH  - Tetralogy of Fallot/*diagnostic imaging/physiopathology/surgery
MH  - Ventricular Dysfunction, Right/*diagnostic imaging/etiology/physiopathology
MH  - *Ventricular Function, Right
MH  - *Ventricular Pressure
MH  - Young Adult
PMC - PMC8015087
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Pressure overload
OT  - Right ventricular function
OT  - Strain
OT  - Volume overload
COIS- The authors declare that they have no competing interests.
EDAT- 2021/04/02 06:00
MHDA- 2021/08/17 06:00
PMCR- 2021/04/01
CRDT- 2021/04/01 05:35
PHST- 2020/08/12 00:00 [received]
PHST- 2021/02/02 00:00 [accepted]
PHST- 2021/04/01 05:35 [entrez]
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2021/08/17 06:00 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - S1097-6647(23)00379-4 [pii]
AID - 724 [pii]
AID - 10.1186/s12968-021-00724-5 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2021 Apr 1;23(1):38. doi: 10.1186/s12968-021-00724-5.