PMID- 33790397 OWN - NLM STAT- MEDLINE DCOM- 20220331 LR - 20221026 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 75 IP - 11 DP - 2021 Nov TI - Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus. PG - 1645-1653 LID - 10.1038/s41430-021-00870-0 [doi] AB - OBJECTIVES: Arterial stiffness (AS), one of the complications of diabetes, associated with many metabolic factors. This study aimed to investigate the association between 25-hydroxyvitamin D(25(OH)D) and AS in type 2 diabetes mellitus (T2DM). METHODS: We identified 1335 diabetic patients from the Department of Endocrinology, Shanghai Tenth People's Hospital. Finally, 603 T2DM patients were included in the study. They were divided into two groups: AS group (baPWV >/= 15,500 cm/s) and the control group (baPWV < 1550 cm/s). RESULTS: (1) Heart rate (HR) and systolic pressure (SBP) were higher while body weight and body mass index (BMI) were smaller in AS group than the control group (all P < 0.05). (2) Compared to patients without AS, patients with AS showed lower 25(OH)D and higher rate of 25(OH)D deficiency (42 +/- 16 vs. 45 +/- 17 mol/l, 68% vs. 64%, all P < 0.05). (3) BaPWV was negatively associated with 25(OH)D (r = -0.12, P = 0.004), while positively associated with age, duration of diabetes, HR, SBP, and low-density lipoprotein cholesterol and negatively associated with body weight and BMI (all P < 0.05). (4) Multiple linear regression showed that 25(OH)D was the negatively influencing factor of baPWV (beta = -2.2, P = 0.01). Logistic regression showed that age and SBP were risk factor of AS (OR:1.07, 95% CI: 1.05-1.10, P < 0.001; OR:1.03, 95% CI: 1.02-1.04, P < 0.001) while 25(OH)D was protective factor of AS (OR:0.987, 95% CI: 0.976-0.998, P = 0.024). CONCLUSIONS: T2DM patients with AS had lower 25(OH)D and higher rate of 25(OH)D deficiency. There was a negative relationship between 25(OH)D and AS assessed by baPWV. CI - (c) 2021. The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature. FAU - Ma, Bingwei AU - Ma B AD - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. AD - Department of Gastrointestinal Surgery, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China. FAU - Chen, Yao AU - Chen Y AD - Chengdu Second People's Hospital, Chengdu, Sichuan Province, China. FAU - Sheng, Chunjun AU - Sheng C AD - Thyroid Research Center of Shanghai, Shanghai, China. FAU - Yang, Peng AU - Yang P AD - Thyroid Research Center of Shanghai, Shanghai, China. FAU - Wang, Xingchun AU - Wang X AUID- ORCID: 0000-0003-3777-2525 AD - Thyroid Research Center of Shanghai, Shanghai, China. 2316154780@qq.com. FAU - Qu, Shen AU - Qu S AD - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. qushencn@hotmail.com. AD - Thyroid Research Center of Shanghai, Shanghai, China. qushencn@hotmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210331 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM EIN - Eur J Clin Nutr. 2022 Nov;76(11):1630. PMID: 35551256 MH - Ankle Brachial Index MH - China/epidemiology MH - *Diabetes Mellitus, Type 2/complications MH - Humans MH - Pulse Wave Analysis MH - Risk Factors MH - *Vascular Stiffness MH - Vitamin D/analogs & derivatives EDAT- 2021/04/02 06:00 MHDA- 2022/04/01 06:00 CRDT- 2021/04/01 06:17 PHST- 2020/08/09 00:00 [received] PHST- 2021/01/26 00:00 [accepted] PHST- 2021/01/03 00:00 [revised] PHST- 2021/04/02 06:00 [pubmed] PHST- 2022/04/01 06:00 [medline] PHST- 2021/04/01 06:17 [entrez] AID - 10.1038/s41430-021-00870-0 [pii] AID - 10.1038/s41430-021-00870-0 [doi] PST - ppublish SO - Eur J Clin Nutr. 2021 Nov;75(11):1645-1653. doi: 10.1038/s41430-021-00870-0. Epub 2021 Mar 31.