PMID- 33790537
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 15
DP  - 2021
TI  - Factors Determining the Morphology of Peripapillary Retinoschisis.
PG  - 1293-1300
LID - 10.2147/OPTH.S301196 [doi]
AB  - PURPOSE: We conducted cross-sectional examinations to determine the frequency of 
      peripapillary retinoschisis (PRS) in eyes with glaucoma and suspected glaucoma 
      and analyzed the pathogenesis of PRS by using spectral-domain optical coherence 
      tomography (SD-OCT). PATIENTS AND METHODS: In 1516 cases involving glaucoma and 
      suspected glaucoma, we retrospectively reviewed the disc and macular volume scans 
      obtained by SD-OCT and categorized PRS into two groups based on whether the 
      retinoschisis was closer to the optic nerve over the Bruch's membrane opening 
      (BMO) (ahead group) or did not go past the BMO (behind group) and then compared 
      the characteristics between both groups. RESULTS: The total frequency of PRS was 
      1.49% (20/1342 eyes) in primary open-angle glaucoma (POAG) eyes and 0.59% 
      (10/1687 eyes) in glaucoma suspects. In the behind group, PRS was mostly detected 
      in the inner layers of the retina (retinal nerve fiber layer: 30.9%, ganglion 
      cell layer: 21.8%, inner plexiform layer: 7.3%). However, in the ahead group, PRS 
      was detected in the outer layers (inner nuclear layer: 10%, outer plexiform 
      layer: 20%, outer nuclear layer: 50%). In addition, the eyes in the ahead group 
      had significantly greater axial lengths and significantly smaller spherical 
      equivalent values. These two differences suggest that the pulling force of the 
      vitreous traction may play an important role in PRS only in the behind group and 
      that the scleral stretching force may play a role in the development of PRS in 
      the ahead group. CONCLUSION: The frequency of PRS in patients with POAG is higher 
      than that in patients with suspected glaucoma. Both forms of PRS are affected by 
      posterior vitreous detachment and axial length elongation. Careful follow-up is 
      required to assess the development of PRS in glaucoma suspects. The pathogenesis 
      of PRS has been elucidated to some degree by classifying the morphological 
      condition of the PRS and BMO.
CI  - (c) 2021 Nishijima et al.
FAU - Nishijima, Reimi
AU  - Nishijima R
AUID- ORCID: 0000-0003-1966-335X
AD  - Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 
      Japan.
AD  - Department of Ophthalmology, The Jikei University Katsushika Medical Center, 
      Tokyo, Japan.
FAU - Ogawa, Shumpei
AU  - Ogawa S
AUID- ORCID: 0000-0003-3841-6004
AD  - Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 
      Japan.
FAU - Nishijima, Euido
AU  - Nishijima E
AD  - Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 
      Japan.
FAU - Itoh, Yoshinori
AU  - Itoh Y
AD  - Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 
      Japan.
FAU - Yoshikawa, Keiji
AU  - Yoshikawa K
AUID- ORCID: 0000-0003-2320-0745
AD  - Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 
      Japan.
AD  - Yoshikawa Eye Clinic, Machida-city, Tokyo, Japan.
FAU - Nakano, Tadashi
AU  - Nakano T
AUID- ORCID: 0000-0002-3184-1991
AD  - Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20210325
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC8006975
OTO - NOTNLM
OT  - glaucoma
OT  - myopia
OT  - optical coherent tomography
OT  - peripapillary retinoschisis
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/04/02 06:00
MHDA- 2021/04/02 06:01
PMCR- 2021/03/25
CRDT- 2021/04/01 06:23
PHST- 2021/01/09 00:00 [received]
PHST- 2021/02/23 00:00 [accepted]
PHST- 2021/04/01 06:23 [entrez]
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2021/04/02 06:01 [medline]
PHST- 2021/03/25 00:00 [pmc-release]
AID - 301196 [pii]
AID - 10.2147/OPTH.S301196 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2021 Mar 25;15:1293-1300. doi: 10.2147/OPTH.S301196. eCollection 
      2021.