PMID- 33790706
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210402
IS  - 1662-0631 (Print)
IS  - 1662-0631 (Electronic)
IS  - 1662-0631 (Linking)
VI  - 15
IP  - 1
DP  - 2021 Jan-Apr
TI  - Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton 
      Pump Inhibitor in a Patient with Liver Cirrhosis.
PG  - 202-209
LID - 10.1159/000511885 [doi]
AB  - Here, we report on a rare case of gastric hyperplastic polyps which disappeared 
      after the discontinuation of proton pump inhibitor (PPI). The patient was an 
      83-year-old woman with liver cirrhosis and portal hypertension, along with 
      gastroesophageal reflux disease treated by PPI. An initial upper gastrointestinal 
      endoscopy showed unique polypoid lesions in the greater curvature of the stomach. 
      Biopsy specimens of the lesions were diagnosed as hyperplastic polyps and she was 
      followed. One year later, a second endoscopy showed that the lesions had 
      increased in number and size, and an endoscopic mucosal resection (EMR) was 
      performed for the main polyps. The resected specimens indicated a proliferation 
      of foveolar epithelium cells with an increase of capillary ectasia and parietal 
      cell hyperplasia, which was thought to be induced by hypergastrinemia from the 
      PPI. Three months after the EMR, she was admitted because of bleeding from the 
      remaining polyps along with an increase in new polyps. After conservative 
      treatment, PPI was stopped and rebamipide was used. One year and 6 months later, 
      an endoscopy showed the complete disappearance of all gastric polyps.
CI  - Copyright (c) 2021 by S. Karger AG, Basel.
FAU - Yasugi, Kengo
AU  - Yasugi K
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
FAU - Haruma, Ken
AU  - Haruma K
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
FAU - Kawanaka, Miwa
AU  - Kawanaka M
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
FAU - Suehiro, Mitsuhiko
AU  - Suehiro M
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
FAU - Nakamura, Jun
AU  - Nakamura J
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
FAU - Urata, Noriyo
AU  - Urata N
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
FAU - Tanikawa, Tomohiro
AU  - Tanikawa T
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
FAU - Oka, Takahito
AU  - Oka T
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
FAU - Monobe, Yasumasa
AU  - Monobe Y
AD  - Department of Pathology, Kawasaki Medical School General Medical Center, Okayama, 
      Japan.
FAU - Fujita, Takuya
AU  - Fujita T
AD  - Fujita Hospital, Okayama, Japan.
FAU - Kawamoto, Hirofumi
AU  - Kawamoto H
AD  - Department of Internal Medicine 2, Kawasaki Medical School General Medical 
      Center, Okayama, Japan.
LA  - eng
PT  - Case Reports
DEP - 20210218
PL  - Switzerland
TA  - Case Rep Gastroenterol
JT  - Case reports in gastroenterology
JID - 101474819
PMC - PMC7989726
OTO - NOTNLM
OT  - Gastric hyperplastic polyp
OT  - Hypergastrinemia
OT  - Proton pump inhibitor
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/04/02 06:00
MHDA- 2021/04/02 06:01
PMCR- 2021/02/18
CRDT- 2021/04/01 06:25
PHST- 2020/09/04 00:00 [received]
PHST- 2020/09/18 00:00 [accepted]
PHST- 2021/04/01 06:25 [entrez]
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2021/04/02 06:01 [medline]
PHST- 2021/02/18 00:00 [pmc-release]
AID - crg-0015-0202 [pii]
AID - 10.1159/000511885 [doi]
PST - epublish
SO  - Case Rep Gastroenterol. 2021 Feb 18;15(1):202-209. doi: 10.1159/000511885. 
      eCollection 2021 Jan-Apr.