PMID- 33790742
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230907
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 15
DP  - 2021
TI  - Perspectives on ROCK2 as a Therapeutic Target for Alzheimer's Disease.
PG  - 636017
LID - 10.3389/fncel.2021.636017 [doi]
LID - 636017
AB  - Rho-associated coiled-coil containing kinase isoform 2 (ROCK2) is a member of the 
      AGC family of serine/threonine kinases and an extensively studied regulator of 
      actin-mediated cytoskeleton contractility. Over the past decade, new evidence has 
      emerged that suggests ROCK2 regulates autophagy. Recent studies indicate that 
      dysregulation of autophagy contributes to the development of misfolded tau 
      aggregates among entorhinal cortex (EC) excitatory neurons in early Alzheimer's 
      disease (AD). While the accumulation of tau oligomers and fibrils is toxic to 
      neurons, autophagy facilitates the degradation of these pathologic species and 
      represents a major cellular pathway for tau disposal in neurons. ROCK2 is 
      expressed in excitatory neurons and pharmacologic inhibition of ROCK2 can induce 
      autophagy pathways. In this mini-review, we explore potential mechanisms by which 
      ROCK2 mediates autophagy and actin dynamics and discuss how these pathways 
      represent therapeutic avenues for Alzheimer's disease.
CI  - Copyright (c) 2021 Weber and Herskowitz.
FAU - Weber, Audrey J
AU  - Weber AJ
AD  - Center for Neurodegeneration and Experimental Therapeutics, Departments of 
      Neurology and Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 
      United States.
FAU - Herskowitz, Jeremy H
AU  - Herskowitz JH
AD  - Center for Neurodegeneration and Experimental Therapeutics, Departments of 
      Neurology and Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 
      United States.
LA  - eng
GR  - R01 AG061800/AG/NIA NIH HHS/United States
GR  - R01 AG054719/AG/NIA NIH HHS/United States
GR  - R01 AG057911/AG/NIA NIH HHS/United States
GR  - RF1 AG063755/AG/NIA NIH HHS/United States
GR  - T32 NS095775/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20210315
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC8005730
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - ROCK2
OT  - autophagy
OT  - dendritic spine
OT  - mTOR
OT  - tau
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/04/02 06:00
MHDA- 2021/04/02 06:01
PMCR- 2021/01/01
CRDT- 2021/04/01 06:25
PHST- 2020/11/30 00:00 [received]
PHST- 2021/02/19 00:00 [accepted]
PHST- 2021/04/01 06:25 [entrez]
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2021/04/02 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2021.636017 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2021 Mar 15;15:636017. doi: 10.3389/fncel.2021.636017. 
      eCollection 2021.