PMID- 33790943
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210402
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 12
DP  - 2021
TI  - A Critical Role of Peptidylprolyl Isomerase A Pseudogene 
      22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma.
PG  - 604461
LID - 10.3389/fgene.2021.604461 [doi]
LID - 604461
AB  - The burden of hepatocellular carcinoma (HCC) worldwide is increasing over time, 
      while the underlying molecular mechanism of HCC development is still under 
      exploration. Pseudogenes are classified as a special type of long non-coding RNAs 
      (lncRNAs), and they played a vital role in regulating tumor-associated gene 
      expression. Here, we report that a pseudogene peptidylprolyl isomerase A 
      pseudogene 22 (PPIAP22) and its parental gene peptidylprolyl isomerase A (PPIA) 
      were upregulated in HCC and were associated with the clinical outcomes of HCC. 
      Further investigation revealed that PPIAP22 might upregulate the expression of 
      PPIA through sponging microRNA (miR)-197-3p, behaving as competing endogenous RNA 
      (ceRNA). PPIA could participate in the development of HCC by regulating mRNA 
      metabolic process and tumor immunity based on the functional enrichment analysis. 
      We also found a strong correlation between the expression levels of PPIA and the 
      immune cell infiltration or the expression of chemokines, especially macrophage, 
      C-C motif chemokine ligand 15 (CCL15), and C-X-C motif chemokine ligand 12 
      (CXCL12). Our findings demonstrate that the PPIAP22/miR-197-3p/PPIA axis plays a 
      vital role in the progression of HCC by increasing the malignancy of tumor cells 
      and regulating the immune cell infiltration, especially macrophage, through 
      CCL15-CCR1 or CXCL12-CXCR4/CXCR7 pathways.
CI  - Copyright (c) 2021 Gu, Wang, Chen, Tang, Guo, Hu, Cui, Zhang, Yu and Chen.
FAU - Gu, Yuwei
AU  - Gu Y
AD  - Department of Infectious Diseases, Huashan Hospital, Shanghai, China.
FAU - Wang, Chao
AU  - Wang C
AD  - Emergency Department, Huashan Hospital, Shanghai, China.
FAU - Chen, Shengsen
AU  - Chen S
AD  - Department of Endoscopy, Cancer Hospital of the University of Chinese Academy of 
      Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
AD  - Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, 
      Hangzhou, China.
FAU - Tang, Jia
AU  - Tang J
AD  - Department of Infectious Diseases, Huashan Hospital, Shanghai, China.
FAU - Guo, Xiaoxiao
AU  - Guo X
AD  - Department of Infectious Diseases, Huashan Hospital, Shanghai, China.
FAU - Hu, Wei
AU  - Hu W
AD  - Shanghai Medical College of Fudan University, Shanghai, China.
FAU - Cui, An
AU  - Cui A
AD  - Department of Infectious Diseases, Huashan Hospital, Shanghai, China.
FAU - Zhang, Dian
AU  - Zhang D
AD  - Emergency Department, Huashan Hospital, Shanghai, China.
FAU - Yu, Kangkang
AU  - Yu K
AD  - Department of Infectious Diseases, Huashan Hospital, Shanghai, China.
FAU - Chen, Mingquan
AU  - Chen M
AD  - Department of Infectious Diseases, Huashan Hospital, Shanghai, China.
AD  - Emergency Department, Huashan Hospital, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20210315
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC8006304
OTO - NOTNLM
OT  - PPIA
OT  - chemokine
OT  - hepatocellular carcinoma
OT  - macrophage
OT  - pseudogene
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The reviewers YC and C-YW declared a shared affiliation, 
      with no collaboration, with several of the authors YG, CW, JT, XG, WH, AC, DZ, 
      KY, and MC to the handling editor at the time of the review.
EDAT- 2021/04/02 06:00
MHDA- 2021/04/02 06:01
PMCR- 2021/03/15
CRDT- 2021/04/01 06:26
PHST- 2020/09/09 00:00 [received]
PHST- 2021/02/26 00:00 [accepted]
PHST- 2021/04/01 06:26 [entrez]
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2021/04/02 06:01 [medline]
PHST- 2021/03/15 00:00 [pmc-release]
AID - 10.3389/fgene.2021.604461 [doi]
PST - epublish
SO  - Front Genet. 2021 Mar 15;12:604461. doi: 10.3389/fgene.2021.604461. eCollection 
      2021.