PMID- 33791308
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 9
DP  - 2021
TI  - Which Hyperglycemic Model of Zebrafish (Danio rerio) Suites My Type 2 Diabetes 
      Mellitus Research? A Scoring System for Available Methods.
PG  - 652061
LID - 10.3389/fcell.2021.652061 [doi]
LID - 652061
AB  - Despite extensive studies on type 2 diabetes mellitus (T2DM), there is no 
      definitive cure, drug, or prevention. Therefore, for developing new therapeutics, 
      proper study models of T2DM is necessary to conduct further preclinical 
      researches. Diabetes has been induced in animals using chemical, genetic, 
      hormonal, antibody, viral, and surgical methods or a combination of them. Beside 
      different approaches of diabetes induction, different animal species have been 
      suggested. Although more than 85% of articles have proposed rat (genus Rattus) as 
      the proper model for diabetes induction, zebrafish (Danio rerio) models of 
      diabetes are being used more frequently in diabetes related studies. In this 
      systematic review, we compare different aspects of available methods of inducing 
      hyperglycemia referred as T2DM in zebrafish by utilizing a scoring system. 
      Evaluating 26 approved models of T2DM in zebrafish, this scoring system may help 
      researchers to compare different T2DM zebrafish models and select the best one 
      regarding their own research theme. Eventually, glyoxalase1 (glo1(-/-)) knockout 
      model of hyperglycemia achieved the highest score. In addition to assessment of 
      hyperglycemic induction methods in zebrafish, eight most commonly proposed 
      diabetic induction approval methods are suggested to help researchers confirm 
      their subsequent proposed models.
CI  - Copyright (c) 2021 Salehpour, Rezaei, Khoradmehr, Tahamtani and Tamadon.
FAU - Salehpour, Aria
AU  - Salehpour A
AD  - The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf 
      Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, 
      Bandar Bushehr, Iran.
FAU - Rezaei, Mohammad
AU  - Rezaei M
AD  - Department of Diabetes, Obesity and Metabolism, Cell Science Research Center, 
      Royan Institute for Stem Cell Biology and Technology, Academic Center for 
      Education, Culture and Research, Tehran, Iran.
FAU - Khoradmehr, Arezoo
AU  - Khoradmehr A
AD  - The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf 
      Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, 
      Bandar Bushehr, Iran.
FAU - Tahamtani, Yaser
AU  - Tahamtani Y
AD  - Department of Diabetes, Obesity and Metabolism, Cell Science Research Center, 
      Royan Institute for Stem Cell Biology and Technology, Academic Center for 
      Education, Culture and Research, Tehran, Iran.
AD  - Department of Stem Cells and Developmental Biology, Cell Science Research Center, 
      Royan Institute for Stem Cell Biology and Technology, Academic Center for 
      Education, Culture and Research, Tehran, Iran.
AD  - Reproductive Epidemiology Research Center, Royan Institute for Reproductive 
      Biomedicine, Academic Center for Education, Culture and Research, Tehran, Iran.
FAU - Tamadon, Amin
AU  - Tamadon A
AD  - The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf 
      Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, 
      Bandar Bushehr, Iran.
AD  - Center of Marine Experimental and Comparative Medicine, The Persian Gulf Marine 
      Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research 
      Institute, Bushehr University of Medical Sciences, Bandar Bushehr, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210315
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC8005598
OTO - NOTNLM
OT  - Danio rerio (zebrafish)
OT  - T2DM
OT  - animal modeling
OT  - diabetes mellitus
OT  - hyperglycemia
OT  - zebrafish
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/04/02 06:00
MHDA- 2021/04/02 06:01
PMCR- 2021/01/01
CRDT- 2021/04/01 06:31
PHST- 2021/01/11 00:00 [received]
PHST- 2021/02/12 00:00 [accepted]
PHST- 2021/04/01 06:31 [entrez]
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2021/04/02 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2021.652061 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2021 Mar 15;9:652061. doi: 10.3389/fcell.2021.652061. 
      eCollection 2021.