PMID- 33792148
OWN - NLM
STAT- MEDLINE
DCOM- 20210604
LR  - 20210604
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 36
IP  - 7
DP  - 2021 Jul
TI  - ROCK inhibitor attenuates carbon blacks-induced pulmonary fibrosis in mice via 
      Rho/ROCK/NF-kappa B pathway.
PG  - 1476-1484
LID - 10.1002/tox.23135 [doi]
AB  - Exposure to carbon blacks (CBs) has been associated with the progression of 
      pulmonary fibrosis, whereas the mechanism is still not clear. We therefore aimed 
      to investigate the effect of RhoA/ROCK pathway on pulmonary fibrosis caused by 
      CBs exposure. Western blot analysis indicated that CBs could promote the 
      activation of RhoA/ROCK pathway and phosphorylation of p65 and IkappaBalpha in mice lung. 
      However, ROCK inhibitor Y-27632 could attenuate phosphorylation levels of p65 and 
      IkappaBalpha and restore histopathological changes of the lung tissue. Then, we evaluated 
      the effect of RhoA/ROCK pathway on pulmonary fibrosis by detecting the expression 
      levels of alpha-SMA, vimentin, and Collagen type-I (Col-I), which could be partly 
      inhibited by Y-27632. It was assumed that inhibition of ROCK could be a promising 
      therapeutic candidate for CBs-induced pulmonary fibrosis, which possibly through 
      the blockage of RhoA/ROCK/NF-kappaB pathway.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Yan, Junyan
AU  - Yan J
AUID- ORCID: 0000-0002-2395-8284
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
FAU - Tang, Yaxin
AU  - Tang Y
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
FAU - Zhong, Xin
AU  - Zhong X
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
FAU - Huang, Huarong
AU  - Huang H
AD  - College of Life and Environmental Science, Hangzhou Normal University, Hangzhou, 
      China.
FAU - Wei, Haonan
AU  - Wei H
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
FAU - Jin, Yulei
AU  - Jin Y
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
FAU - He, Yanjiang
AU  - He Y
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
FAU - Cao, Jinqiao
AU  - Cao J
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
FAU - Jin, Lifang
AU  - Jin L
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
AD  - Shaoxing Academy of Biomedicine of Zhejiang Sci-Tech University, Zhejiang, China.
FAU - Hu, Baowei
AU  - Hu B
AD  - School of Life Science, Shaoxing University, Shaoxing, China.
LA  - eng
GR  - LQ20B070003/Natural Science Foundation of Zhejiang Province/
GR  - SXAB202015/Shaoxing Academy of Biomedicine of Zhejiang Sci-Tech University/
GR  - 2018C37105/Zhejiang Province Science and Technology Project of China/
PT  - Journal Article
DEP - 20210331
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (NF-kappa B)
RN  - 0 (Soot)
RN  - 7440-44-0 (Carbon)
RN  - EC 2.7.11.1 (rho-Associated Kinases)
RN  - EC 3.6.5.2 (rhoA GTP-Binding Protein)
SB  - IM
MH  - Animals
MH  - Carbon
MH  - Mice
MH  - *NF-kappa B/metabolism
MH  - *Pulmonary Fibrosis/chemically induced/drug therapy
MH  - Soot
MH  - rho-Associated Kinases/metabolism
MH  - rhoA GTP-Binding Protein/metabolism
OTO - NOTNLM
OT  - NF-kappa B
OT  - RhoA/rho kinase
OT  - Y-27632
OT  - carbon black
OT  - pulmonary fibrosis
EDAT- 2021/04/02 06:00
MHDA- 2021/06/05 06:00
CRDT- 2021/04/01 06:51
PHST- 2020/09/16 00:00 [received]
PHST- 2021/03/13 00:00 [accepted]
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2021/06/05 06:00 [medline]
PHST- 2021/04/01 06:51 [entrez]
AID - 10.1002/tox.23135 [doi]
PST - ppublish
SO  - Environ Toxicol. 2021 Jul;36(7):1476-1484. doi: 10.1002/tox.23135. Epub 2021 Mar 
      31.