PMID- 33792460
OWN - NLM
STAT- MEDLINE
DCOM- 20220530
LR  - 20220715
IS  - 1563-5244 (Electronic)
IS  - 0883-0185 (Linking)
VI  - 41
IP  - 3
DP  - 2022
TI  - Immune metabolism: a bridge of dendritic cells function.
PG  - 313-325
LID - 10.1080/08830185.2021.1897124 [doi]
AB  - An increasing number of researches have shown that cell metabolism regulates cell 
      function. Dendritic cells (DCs), a professional antigen presenting cells, connect 
      innate and adaptive immune responses. The preference of DCs for sugar or lipid 
      affects its phenotypes and functions. In many diseases such as atherosclerosis 
      (AS), diabetes mellitus and tumor, altered glucose or lipid level in 
      microenvironment makes DCs exert ineffective or opposite immune roles, which 
      accelerates the development of these diseases. In this article, we review the 
      metabolism pathways of glucose and cholesterol in DCs, and the effects of 
      metabolic changes on the phenotype and function of DCs. In addition, we discuss 
      the effects of changes in glucose and lipid levels on DCs in the context of 
      different diseases for better understanding the relationship between DCs and 
      diseases. The immune metabolism of DCs may be a potential intervention link to 
      treat metabolic-related immune diseases.
FAU - Sun, Yuting
AU  - Sun Y
AD  - School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation 
      of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 
      People's Republic of China.
FAU - Zhou, Liyu
AU  - Zhou L
AD  - School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation 
      of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 
      People's Republic of China.
FAU - Chen, Weikai
AU  - Chen W
AD  - School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation 
      of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 
      People's Republic of China.
FAU - Zhang, Linhui
AU  - Zhang L
AD  - School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation 
      of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 
      People's Republic of China.
FAU - Zeng, Hongbo
AU  - Zeng H
AD  - School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation 
      of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 
      People's Republic of China.
FAU - Sun, Yunxia
AU  - Sun Y
AD  - Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of 
      Chinese Medicine, Nanjing, People's Republic of China.
FAU - Long, Jun
AU  - Long J
AD  - School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation 
      of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 
      People's Republic of China.
FAU - Yuan, Dongping
AU  - Yuan D
AUID- ORCID: 0000-0002-2063-0304
AD  - School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation 
      of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210401
PL  - England
TA  - Int Rev Immunol
JT  - International reviews of immunology
JID - 8712260
RN  - 0 (Lipids)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Atherosclerosis/metabolism
MH  - Dendritic Cells
MH  - Glucose/metabolism
MH  - Humans
MH  - Lipids
MH  - *Neoplasms
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Cholesterol metabolism
OT  - dendritic cell
OT  - glucose metabolism
OT  - immune response
OT  - inflammation
EDAT- 2021/04/02 06:00
MHDA- 2022/05/31 06:00
CRDT- 2021/04/01 12:22
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2022/05/31 06:00 [medline]
PHST- 2021/04/01 12:22 [entrez]
AID - 10.1080/08830185.2021.1897124 [doi]
PST - ppublish
SO  - Int Rev Immunol. 2022;41(3):313-325. doi: 10.1080/08830185.2021.1897124. Epub 
      2021 Apr 1.