PMID- 33793790
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20220422
IS  - 2042-7158 (Electronic)
IS  - 0022-3573 (Linking)
VI  - 74
IP  - 4
DP  - 2022 Apr 20
TI  - Cognition, oxidative stress and vitamin B12 levels evaluation on patients under 
      long-term omeprazole use.
PG  - 547-555
LID - 10.1093/jpp/rgab001 [doi]
AB  - OBJECTIVES: To evaluate the differences concerning cognitive performance, 
      oxidative stress and vitamin B12 levels in omeprazole users under treatment for 
      longer than six months. METHODS: A case-control study was developed with 44 
      omeprazole users (OU; 81.8 % female, 66 +/- 8.7 years old) and 35 nonusers (NOU; 
      88.6 % female, 62 +/- 8.7 years old). The cognitive ability was assessed through 
      tests approaching attention, memory and executive functions. The vitamin B12 was 
      dosage using a chemiluminescent immunoassay and oxidative stress analysis, based 
      on the evaluation of malondialdehyde, enzymatic activity of extracellular 
      superoxide dismutase, glutathione peroxidase, catalase and the ferric reducing 
      antioxidant power in plasma. KEY FINDINGS: A significant increase of the ferric 
      reducing antioxidant power [omeprazole users (OU) group = 1690 microM +/- 441 and 
      nonusers (NOU) group = 1308 +/- 616; P value=0.002] and a decrease on glutathione 
      peroxidase levels [OU group = 0.534 (0.27-10.63) and NOU group = 71.86 
      (14.36-173.1); P value=0.006] were found on omeprazole users group, as well as 
      differences on cognitive performance, with impairments on executive functions, 
      automatic and attentional processing. CONCLUSIONS: Long-term use of omeprazole is 
      suggested to induce an oxidative stress condition, which causes neurotoxicity and 
      cognitive decline.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the Royal 
      Pharmaceutical Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Dries, Larissa Selbach
AU  - Dries LS
AD  - Graduate Program on Toxicology and Analytical Toxicology, Feevale University, 
      Novo Hamburgo, RS, Brazil.
FAU - Haefliger, Rochelli
AU  - Haefliger R
AD  - Graduated in Psychology, Feevale University, Novo Hamburgo, RS, Brazil.
FAU - Seibert, Bruna Sherer
AU  - Seibert BS
AD  - Graduated in Pharmacy, Feevale University, Novo Hamburgo, RS, Brazil.
FAU - de Lima, Angelica Gewehr
AU  - de Lima AG
AD  - Graduated in Pharmacy, Feevale University, Novo Hamburgo, RS, Brazil.
FAU - Cardoso, Caroline de Oliveira
AU  - Cardoso CO
AD  - Psychology Course, Feevale University, Novo Hamburgo, RS, Brazil.
FAU - Perassolo, Magda Susana
AU  - Perassolo MS
AUID- ORCID: 0000-0002-8122-8896
AD  - Program on Toxicology and Analytical Toxicology, Feevale University, Novo 
      Hamburgo, RS, Brazil.
LA  - eng
GR  - 25.173.18.2705/Universidade Feevale/
PT  - Journal Article
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Antioxidants)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - KG60484QX9 (Omeprazole)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Aged
MH  - *Antioxidants/analysis
MH  - Case-Control Studies
MH  - Cognition
MH  - Female
MH  - Glutathione Peroxidase
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Omeprazole/adverse effects
MH  - Oxidative Stress
MH  - Superoxide Dismutase/metabolism
MH  - Vitamin B 12
OTO - NOTNLM
OT  - PPIs
OT  - cognitive impairment
OT  - omeprazole
OT  - oxidative stress
OT  - vitamin B12
EDAT- 2021/04/02 06:00
MHDA- 2022/04/23 06:00
CRDT- 2021/04/01 17:36
PHST- 2020/11/13 00:00 [received]
PHST- 2021/01/08 00:00 [accepted]
PHST- 2021/04/02 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
PHST- 2021/04/01 17:36 [entrez]
AID - 6146343 [pii]
AID - 10.1093/jpp/rgab001 [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 2022 Apr 20;74(4):547-555. doi: 10.1093/jpp/rgab001.