PMID- 33794864
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20211122
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Apr 1
TI  - Skin autofluorescence and the complexity of complications in patients with type 2 
      diabetes mellitus: a cross-sectional study.
PG  - 58
LID - 10.1186/s12902-021-00725-6 [doi]
LID - 58
AB  - BACKGROUND: The accumulation of advanced glycation end products (AGEs) occurring 
      in skin tissues can be measured as skin autofluorescence (SAF). Here, we assessed 
      the correlation between SAF values and the complexity and severity of type 2 
      diabetes mellitus (T2DM) complications. METHODS: The basic clinical information 
      of 825 patients with T2DM was collected through an electronic system, and SAF was 
      measured by adapting a DM-Scan, a non-invasive optical signal detector. Diabetic 
      complications were diagnosed based on clinical criteria by experienced doctors. 
      Linear regression analysis was used to evaluate the independent determinants of 
      SAF, and multiple logistic regression analysis was performed to assess 
      independent determinants that influence the severity of the complications. 
      RESULTS: SAF was significantly associated with the complexity of T2DM 
      complications. Similarly, independent relationships between SAF and age 
      (beta = 0.389, P <  0.001), sex (beta = - 2.221, P = 0.004), 2-h C-peptide 
      (beta = - 0.182, P = 0.017), aminotransferase (ALT, beta = - 0.158, P = 0.041), blood 
      creatinine (BCr, beta = 0.206, P = 0.009), and fatty liver (beta = 0.161, P = 0.026) 
      were observed. With the increasing number of complications, the SAF values 
      increased significantly after adjusting for related risk factors. The SAF values 
      correlated with diabetic retinopathy, diabetic kidney diseases, cardiovascular 
      disease, and diabetic peripheral neuropathy when compared with patients without 
      any T2DM-associated complications. Moreover, the AGE-based diabetic complication 
      risk score for each complication demonstrated a relationship with the presence or 
      absence of certain complications. CONCLUSION: SAF is an independent marker for 
      diabetic retinopathy, diabetic kidney diseases, cardiovascular disease, and 
      diabetic peripheral neuropathy, and it is also a predictor of the complexity of 
      T2DM complications. Moreover, the diabetic complication risk score is capable of 
      predicting the risk of diabetic complications in patients with T2DM.
FAU - Wang, Xian
AU  - Wang X
AD  - School of Clinical Medicine, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, China.
FAU - Zhao, Xingwang
AU  - Zhao X
AD  - Department of Endocrinology, Jianyang Traditional Chinese Medicine Hospital, 
      Chengdu, China.
FAU - Lian, Tingting
AU  - Lian T
AD  - Department of Endocrinology, General Hospital of Southern Theater Command, 
      Guangzhou, China.
FAU - Wei, Juanjin
AU  - Wei J
AD  - School of Clinical Medicine, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, China.
FAU - Yue, Wanxu
AU  - Yue W
AD  - School of Clinical Medicine, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, China.
FAU - Zhang, Senwei
AU  - Zhang S
AD  - School of Clinical Medicine, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, China.
FAU - Chen, Qiu
AU  - Chen Q
AD  - Department of Endocrinology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, China. qiuchen1email@163.com.
LA  - eng
GR  - 19ZDYF1497/Sichuan Provincial Science and Technology Planning Project/
PT  - Journal Article
DEP - 20210401
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Glycation End Products, Advanced)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/*metabolism
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Female
MH  - Glycation End Products, Advanced/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Skin/*metabolism
MH  - *Spectrometry, Fluorescence
PMC - PMC8017648
OTO - NOTNLM
OT  - Advanced glycation end products
OT  - Skin autofluorescence
OT  - T2DM complications
COIS- The authors declare that they have no conflict of interest to disclose.
EDAT- 2021/04/03 06:00
MHDA- 2021/11/23 06:00
PMCR- 2021/04/01
CRDT- 2021/04/02 05:34
PHST- 2020/09/03 00:00 [received]
PHST- 2021/03/25 00:00 [accepted]
PHST- 2021/04/02 05:34 [entrez]
PHST- 2021/04/03 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - 10.1186/s12902-021-00725-6 [pii]
AID - 725 [pii]
AID - 10.1186/s12902-021-00725-6 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2021 Apr 1;21(1):58. doi: 10.1186/s12902-021-00725-6.