PMID- 33794945
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1546-0096 (Electronic)
IS  - 1546-0096 (Linking)
VI  - 19
IP  - 1
DP  - 2021 Apr 1
TI  - Epidemiology of pediatric uveitis and associated systemic diseases.
PG  - 48
LID - 10.1186/s12969-021-00516-2 [doi]
LID - 48
AB  - BACKGROUND: The early detection of uveitis associated with systemic inflammatory 
      disease in children is important for proper treatment and prognosis. However, the 
      diagnosis may be delayed because of difficulties in childhood examinations and 
      early minor systemic symptoms. The objective of our study was to identify the 
      pattern of childhood uveitis and investigate the frequency and clinical features 
      of rheumatic diseases in pediatric patients with uveitis. METHODS: This 
      retrospective observational study reviewed the medical records of children 
      (age </= 18 years) with uveitis at a Korean tertiary hospital between January 2005 
      and December 2018. Data collected included the age at onset of uveitis, sex, 
      anatomic location of ocular inflammation, comorbid disease (including systemic 
      inflammatory disease), ocular complications, relevant laboratory data, and 
      treatment. Fisher's exact test was used to compare categorical variables and the 
      Mann-Whitney U test was used to compare continuous variables. A p-value of < 0.05 
      was considered statistically significant. RESULTS: A total of 155 pediatric 
      patients with uveitis were included in this study. The median age at diagnosis 
      was 13.0 years (interquartile range, 9.5-16.0 years). The male-to-female ratio 
      was 1.09. The process was unilateral in 51.6% of children. Anterior uveitis, 
      panuveitis, intermediate uveitis, and posterior uveitis represented 51.6, 26.5, 
      6.5, and 1.9% of the cases, respectively. Idiopathic uveitis (65.2%) was the most 
      frequent type of uveitis. Systemic rheumatic disease associations were 
      responsible for 28.4% of the cases, among which juvenile idiopathic arthritis 
      (JIA) was the most frequent cause (14.8%). Human leukocyte antigen (HLA)-B27 and 
      antinuclear antibody (ANA) positive rates were significantly higher in patients 
      with JIA than in those with idiopathic uveitis (p = 0.006 and p = 0.007, 
      respectively). CONCLUSIONS: Approximately one-third of children with uveitis in 
      Korea have a systemic rheumatic disease, of which JIA accounts for the majority 
      of cases. HLA-B27 and ANA can serve as risk factors for JIA-associated uveitis.
FAU - Shin, Yoonkyeom
AU  - Shin Y
AD  - Department of Pediatrics, Severance Children's Hospital, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
FAU - Kang, Ji-Man
AU  - Kang JM
AD  - Department of Pediatrics, Severance Children's Hospital, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea.
FAU - Lee, Junwon
AU  - Lee J
AD  - Department of Ophthalmology, Institute of Vision Research, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Korea.
FAU - Lee, Christopher Seungkyu
AU  - Lee CS
AD  - Department of Ophthalmology, Institute of Vision Research, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Korea.
FAU - Lee, Sung Chul
AU  - Lee SC
AD  - Department of Ophthalmology, Institute of Vision Research, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Korea.
FAU - Ahn, Jong Gyun
AU  - Ahn JG
AUID- ORCID: 0000-0001-5748-0015
AD  - Department of Pediatrics, Severance Children's Hospital, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea. 
      JGAHN@yuhs.ac.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea. JGAHN@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210401
PL  - England
TA  - Pediatr Rheumatol Online J
JT  - Pediatric rheumatology online journal
JID - 101248897
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Rheumatic Diseases/*complications/*epidemiology
MH  - Uveitis/*complications/*epidemiology
PMC - PMC8015176
OTO - NOTNLM
OT  - Antinuclear antibodies
OT  - Children
OT  - HLA-B27
OT  - Juvenile idiopathic arthritis
COIS- The authors declare no conflicts of interest.
EDAT- 2021/04/03 06:00
MHDA- 2021/11/25 06:00
PMCR- 2021/04/01
CRDT- 2021/04/02 05:38
PHST- 2020/08/20 00:00 [received]
PHST- 2021/03/04 00:00 [accepted]
PHST- 2021/04/02 05:38 [entrez]
PHST- 2021/04/03 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - 10.1186/s12969-021-00516-2 [pii]
AID - 516 [pii]
AID - 10.1186/s12969-021-00516-2 [doi]
PST - epublish
SO  - Pediatr Rheumatol Online J. 2021 Apr 1;19(1):48. doi: 10.1186/s12969-021-00516-2.