PMID- 33795530
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 7
DP  - 2021 Mar 26
TI  - Photobiomodulation therapy ameliorates hyperglycemia and insulin resistance by 
      activating cytochrome c oxidase-mediated protein kinase B in muscle.
PG  - 10015-10033
LID - 10.18632/aging.202760 [doi]
AB  - Ameliorating hyperglycemia and insulin resistance are major therapeutic 
      strategies for type 2 diabetes. Previous studies have indicated that 
      photobiomodulation therapy (PBMT) attenuates metabolic abnormalities in 
      insulin-resistant adipose cells and tissues. However, it remains unclear whether 
      PBMT ameliorates glucose metabolism in skeletal muscle in type 2 diabetes models. 
      Here we showed that PBMT reduced blood glucose and insulin resistance, and 
      reversed metabolic abnormalities in skeletal muscle in two diabetic mouse models. 
      PBMT accelerated adenosine triphosphate (ATP) and reactive oxygen species (ROS) 
      generation by elevating cytochrome c oxidase (CcO) activity. ROS-induced 
      activation of phosphatase and tensin homolog (PTEN)/ protein kinase B (AKT) 
      signaling after PBMT promoted glucose transporter GLUT4 translocation and 
      glycogen synthase (GS) activation, accelerating glucose uptake and glycogen 
      synthesis in skeletal muscle. CcO subunit III deficiency, ROS elimination, and 
      AKT inhibition suppressed the PBMT effects of glucose metabolism in skeletal 
      muscle. This study indicated amelioration of glucose metabolism after PBMT in 
      diabetic mouse models and revealed the metabolic regulatory effects and 
      mechanisms of PBMT on skeletal muscle.
FAU - Gong, Longlong
AU  - Gong L
AD  - MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, 
      South China Normal University, Guangzhou 510631, China.
AD  - College of Biophotonics, South China Normal University, Guangzhou 510631, China.
FAU - Zou, Zhengzhi
AU  - Zou Z
AD  - MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, 
      South China Normal University, Guangzhou 510631, China.
AD  - College of Biophotonics, South China Normal University, Guangzhou 510631, China.
FAU - Liu, Lei
AU  - Liu L
AD  - MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, 
      South China Normal University, Guangzhou 510631, China.
FAU - Guo, Shuang
AU  - Guo S
AD  - College of Biophotonics, South China Normal University, Guangzhou 510631, China.
FAU - Xing, Da
AU  - Xing D
AD  - MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, 
      South China Normal University, Guangzhou 510631, China.
AD  - College of Biophotonics, South China Normal University, Guangzhou 510631, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210326
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Reactive Oxygen Species)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Animals
MH  - Cell Line
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Electron Transport Complex IV/*metabolism
MH  - Glucose/metabolism
MH  - Hyperglycemia/metabolism/*therapy
MH  - Insulin Resistance/*physiology
MH  - *Low-Level Light Therapy
MH  - Mice
MH  - Muscle, Skeletal/*metabolism
MH  - PTEN Phosphohydrolase/metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction/physiology
MH  - Treatment Outcome
PMC - PMC8064177
OTO - NOTNLM
OT  - PTEN/AKT
OT  - cytochrome c oxidase
OT  - muscle
OT  - photobiomodulation therapy
OT  - type 2 diabetes
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2021/04/03 06:00
MHDA- 2021/07/27 06:00
PMCR- 2021/04/15
CRDT- 2021/04/02 05:57
PHST- 2020/06/24 00:00 [received]
PHST- 2020/11/25 00:00 [accepted]
PHST- 2021/04/03 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2021/04/02 05:57 [entrez]
PHST- 2021/04/15 00:00 [pmc-release]
AID - 202760 [pii]
AID - 10.18632/aging.202760 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Mar 26;13(7):10015-10033. doi: 10.18632/aging.202760. 
      Epub 2021 Mar 26.