PMID- 33796355
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240331
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 12
IP  - 3
DP  - 2021 Mar 1
TI  - Optical biopsy of laryngeal lesions using femtosecond multiphoton microscopy.
PG  - 1308-1319
LID - 10.1364/BOE.414931 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignancy 
      of the upper aerodigestive tract. Detection of early lesions in vivo could 
      improve the survival rate significantly. In this study, we demonstrated that 
      femtosecond multiphoton microscopy (MPM) is an effective tool to visualize the 
      microscopic features within fixed laryngeal tissues, without sectioning, 
      staining, or labeling. Accurate detection of lesions and determination of the 
      tumor grading can be achieved, with excellent consistency with conventional 
      histological examination. These results suggest that MPM may represent a powerful 
      tool for in-vivo or fast ex-vivo diagnosis of laryngeal lesions at the point of 
      care.
CI  - (c) 2021 Optical Society of America under the terms of the OSA Open Access 
      Publishing Agreement.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Department of Pathology, Beijing Tongren Hospital, Capital Medical University; 
      Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 
      100730, China.
AD  - These authors contributed equally to this work.
FAU - Chen, Yan
AU  - Chen Y
AD  - Femtosecond Research Center (Guangzhou), A616 80 Lanyue Road, Guangzhou 510663, 
      China.
AD  - These authors contributed equally to this work.
FAU - Cao, Dingfang
AU  - Cao D
AD  - Department of Pathology, Beijing Tongren Hospital, Capital Medical University; 
      Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 
      100730, China.
FAU - Li, Wenjing
AU  - Li W
AD  - Department of Pathology, Beijing Tongren Hospital, Capital Medical University; 
      Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 
      100730, China.
FAU - Jing, Yanlei
AU  - Jing Y
AD  - Department of Pathology, Beijing Tongren Hospital, Capital Medical University; 
      Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 
      100730, China.
FAU - Zhong, Hua
AU  - Zhong H
AD  - Femtosecond Research Center (Guangzhou), A616 80 Lanyue Road, Guangzhou 510663, 
      China.
FAU - Liu, Honggang
AU  - Liu H
AD  - Department of Pathology, Beijing Tongren Hospital, Capital Medical University; 
      Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 
      100730, China.
AD  - liuhg1125@163.com.
FAU - Zhu, Xin
AU  - Zhu X
AD  - Femtosecond Research Center (Guangzhou), A616 80 Lanyue Road, Guangzhou 510663, 
      China.
AD  - zhuxin@femtoresearch.com.
LA  - eng
PT  - Journal Article
DEP - 20210208
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC7984806
COIS- The authors declare no conflicts of interest.
EDAT- 2021/04/03 06:00
MHDA- 2021/04/03 06:01
PMCR- 2021/03/01
CRDT- 2021/04/02 06:35
PHST- 2020/11/16 00:00 [received]
PHST- 2021/01/17 00:00 [revised]
PHST- 2021/01/24 00:00 [accepted]
PHST- 2021/04/02 06:35 [entrez]
PHST- 2021/04/03 06:00 [pubmed]
PHST- 2021/04/03 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 414931 [pii]
AID - 10.1364/BOE.414931 [doi]
PST - epublish
SO  - Biomed Opt Express. 2021 Feb 8;12(3):1308-1319. doi: 10.1364/BOE.414931. 
      eCollection 2021 Mar 1.