PMID- 33797448
OWN - NLM
STAT- MEDLINE
DCOM- 20210712
LR  - 20230822
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Print)
IS  - 0277-2116 (Linking)
VI  - 73
IP  - 1
DP  - 2021 Jul 1
TI  - Physical Activity and Fatigue in Children With Intestinal Failure on Parenteral 
      Nutrition.
PG  - 110-114
LID - 10.1097/MPG.0000000000003138 [doi]
AB  - OBJECTIVES: With improved survival of children with intestinal failure (IF), it 
      is important to examine the impact on long-term physical function, physical 
      activity (PA), and fatigue and identify clinical factors that may be predictive 
      of impairment. METHODS: Cross-sectional study in children with IF on parenteral 
      nutrition (PN) compared with healthy age- and sex-matched controls (HCs). 
      Assessments included: Paediatric Quality of Life (PedsQL) Physical Function 
      subscale, PedsQL Multi-Dimensional Fatigue Scale, and PA Perceived Benefits and 
      Barriers scale. PA was measured using an accelerometer. Medical data was 
      collected by chart abstraction. RESULTS: Participants included 21 children with 
      IF (14 girls), median age 8.33 (interquartile range [IQR] 6.96-11.04) years and 
      33 HCs (20 boys), 8.25 (6.67-10.79) years. In those with IF, 13 (62%) were born 
      prematurely with a median of 15 (7.5-24.5) in-patient hospitalizations. There was 
      a significant difference (P = 0.033) in mean steps/day in children with IF 
      (9709 +/- 3975) compared with HCs (13104 +/- 5416), and a correlation between 
      moderate-to-vigorous PA and gestational age (r = 0.642, P = 0.010). Child and 
      parent proxy scores indicate poorer physical function and greater fatigue in the 
      IF group, along with a correlation between greater fatigue (r = -0.538, 
      P = 0.012), poorer physical function (r = -0.0650, P = 0.0001) in children with 
      more hospitalizations. Barriers to PA include "I am tired" and "I am worried 
      about my line." CONCLUSIONS: Children with IF present with lower levels of PA and 
      physical function and greater fatigue compared with their peers. Ongoing 
      development of medical and rehabilitation intervention strategies is vital to 
      optimize outcomes.
CI  - Copyright (c) 2021 by European Society for Pediatric Gastroenterology, Hepatology, 
      and Nutrition and North American Society for Pediatric Gastroenterology, 
      Hepatology, and Nutrition.
FAU - So, Stephanie
AU  - So S
AD  - Department of Rehabilitation Services.
AD  - Transplant and Regenerative Medicine Centre.
AD  - Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital 
      for Sick Children, Toronto, Ontario, Canada.
FAU - Patterson, Catherine
AU  - Patterson C
AD  - Department of Rehabilitation Services.
AD  - Transplant and Regenerative Medicine Centre.
AD  - Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital 
      for Sick Children, Toronto, Ontario, Canada.
FAU - Betts, Zachary
AU  - Betts Z
AD  - Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital 
      for Sick Children, Toronto, Ontario, Canada.
FAU - Belza, Christina
AU  - Belza C
AD  - Transplant and Regenerative Medicine Centre.
AD  - Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital 
      for Sick Children, Toronto, Ontario, Canada.
FAU - Avitzur, Yaron
AU  - Avitzur Y
AD  - Transplant and Regenerative Medicine Centre.
AD  - Division of Gastroenterology, Hepatology and Nutrition.
AD  - Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital 
      for Sick Children, Toronto, Ontario, Canada.
FAU - Wales, Paul W
AU  - Wales PW
AD  - Division of General and Thoracic Surgery.
AD  - Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital 
      for Sick Children, Toronto, Ontario, Canada.
LA  - eng
GR  - RC2 DK118640/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
SB  - IM
MH  - Child
MH  - Cross-Sectional Studies
MH  - *Exercise
MH  - Fatigue/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Parenteral Nutrition
MH  - *Quality of Life
PMC - PMC8217365
MID - NIHMS1704871
COIS- The authors report no conflicts of interest.
EDAT- 2021/04/03 06:00
MHDA- 2021/07/13 06:00
PMCR- 2021/07/01
CRDT- 2021/04/02 12:17
PHST- 2021/04/03 06:00 [pubmed]
PHST- 2021/07/13 06:00 [medline]
PHST- 2021/04/02 12:17 [entrez]
PHST- 2021/07/01 00:00 [pmc-release]
AID - 00005176-202107000-00024 [pii]
AID - 10.1097/MPG.0000000000003138 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):110-114. doi: 
      10.1097/MPG.0000000000003138.