PMID- 33800762
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240503
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 13
IP  - 5
DP  - 2021 Mar 6
TI  - Nongaussian Intravoxel Incoherent Motion Diffusion Weighted and Fast Exchange 
      Regime Dynamic Contrast-Enhanced-MRI of Nasopharyngeal Carcinoma: Preliminary 
      Study for Predicting Locoregional Failure.
LID - 10.3390/cancers13051128 [doi]
LID - 1128
AB  - The aim of the present study was to identify whether the quantitative metrics 
      from pre-treatment (TX) non-Gaussian intravoxel incoherent motion (NGIVIM) 
      diffusion weighted (DW-) and fast exchange regime (FXR) dynamic contrast enhanced 
      (DCE)-MRI can predict patients with locoregional failure (LRF) in nasopharyngeal 
      carcinoma (NPC). Twenty-nine NPC patients underwent pre-TX DW- and DCE-MRI on a 
      3T MR scanner. DW imaging data from primary tumors were fitted to monoexponential 
      (ADC) and NGIVIM (D, D*, f, and K) models. The metrics K(trans), v(e), and tau(i) 
      were estimated using the FXR model. Cumulative incidence (CI) analysis and 
      Fine-Gray (FG) modeling were performed considering death as a competing risk. 
      Mean v(e) values were significantly different between patients with and without 
      LRF (p = 0.03). Mean f values showed a trend towards the difference between the 
      groups (p = 0.08). Histograms exhibited inter primary tumor heterogeneity. The CI 
      curves showed significant differences for the dichotomized cutoff value of ADC </= 
      0.68 x 10(-3) (mm(2)/s), D </= 0.74 x 10(-3) (mm(2)/s), and f </= 0.18 (p < 0.05). 
      tau(i) </= 0.89 (s) cutoff value showed borderline significance (p = 0.098). FG's 
      modeling showed a significant difference for the K cutoff value of </=0.86 (p = 
      0.034). Results suggest that the role of pre-TX NGIVIM DW- and FXR 
      DCE-MRI-derived metrics for predicting LRF in NPC than alone.
FAU - Paudyal, Ramesh
AU  - Paudyal R
AD  - Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, 
      NY 10065, USA.
FAU - Chen, Linda
AU  - Chen L
AD  - Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New 
      York, NY 10065, USA.
FAU - Oh, Jung Hun
AU  - Oh JH
AD  - Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, 
      NY 10065, USA.
FAU - Zakeri, Kaveh
AU  - Zakeri K
AD  - Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New 
      York, NY 10065, USA.
FAU - Hatzoglou, Vaios
AU  - Hatzoglou V
AD  - Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 
      10065, USA.
FAU - Tsai, C Jillian
AU  - Tsai CJ
AD  - Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New 
      York, NY 10065, USA.
FAU - Lee, Nancy
AU  - Lee N
AD  - Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New 
      York, NY 10065, USA.
FAU - Shukla-Dave, Amita
AU  - Shukla-Dave A
AD  - Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, 
      NY 10065, USA.
AD  - Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 
      10065, USA.
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - U01 CA211205/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20210306
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC7961986
OTO - NOTNLM
OT  - diffusion weighted
OT  - dynamic contrast-enhanced
OT  - fast exchange regime
OT  - gaussian and non-gaussian
OT  - kurtosis
OT  - metabolic activity
OT  - permeability
COIS- The authors declare no conflict of interest.
EDAT- 2021/04/04 06:00
MHDA- 2021/04/04 06:01
PMCR- 2021/03/06
CRDT- 2021/04/03 01:06
PHST- 2021/02/02 00:00 [received]
PHST- 2021/03/02 00:00 [revised]
PHST- 2021/03/02 00:00 [accepted]
PHST- 2021/04/03 01:06 [entrez]
PHST- 2021/04/04 06:00 [pubmed]
PHST- 2021/04/04 06:01 [medline]
PHST- 2021/03/06 00:00 [pmc-release]
AID - cancers13051128 [pii]
AID - cancers-13-01128 [pii]
AID - 10.3390/cancers13051128 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Mar 6;13(5):1128. doi: 10.3390/cancers13051128.